فهرست مطالب علی قاسمی کهریزسنگی

Exercise interventions and consumption of some supplements can lead to changes in the antioxidant system and oxidative stress of skeletal muscles. Based on this, the present study investigated the effect of four weeks of Nigella sativa oil supplementation and aerobic exercise on the serum levels of malondialdehyde and the total antioxidant capacity of inactive young women. For this purpose, 40 inactive young women with an average age of 22.23 ± 4.51 years and BMI of 25.46 ± 4.21 participated in the research. Prior to the treatment, they filled out a written consent form. Then, the subjects were randomly divided into four groups: control (N=9), exercise + placebo (N=10), supplement (N=10), and exercise + supplement (N=11). The aerobic exercise groups performed four weeks of aerobic exercise with an intensity of 50% to 80% of the maximum heart rate, three sessions a week. Also, the Nigella sativa oil supplement groups received 1000 mg of its capsule per day after lunch. Blood samples were collected to measure the serum level of malondialdehyde and total antioxidant capacity in two stages before and after 24 hours of the last training session in fasting conditions from antecubital vein. Statistical analysis was performed by paired t-tests and the analysis of covariance at a significance level of P<0.05. Results showed that there is a significant decrease in total antioxidant capacity values between the aerobic group with the two supplement groups (P=0.03) and supplement + exercise (P=0.03). Also, a significant decrease was shown after the test as was compared to the pre-test in the within-group values of malondialdehyde serum concentration in the supplement group (P=0.03). According to the results, we conclude that the aerobic exercises and Nigella sativa supplementation leads to a decrease in the total antioxidant capacity and it has no effect on the oxidative index.

Diabetes and obesity are among the main problems of societies, and the main preventable causes of death all over the world. Also, type 2 diabetes is more common in obese people, and obesity itself causes some degree of insulin resistance. The aim of the present study was to investigate the effect of an eight-week aerobic training plus a supplement of Portulaca Oleracea seed on metabolic syndrome factors in middle-aged men with Diabetes Type 2 on the threshold of obesity.

In this experimental study, 40 male patients with type 2 diabetes with an average age of 40-65 and BMI between 28 and 30, were selected and then randomly placed into four groups of control (10 people), exercise + placebo (10 people), supplement (10 people), and exercise + supplement (10 people). Lack of a history of regular sports activity and lack of consumption of Portulaca oleracea plant (for the previous 6 months) were controlled. Also, people who had chronic cardiovascular diseases or chronic inflammation, diabetic foot ulcers and hepatitis, as well as people who took vitamin supplements and smoked, were excluded from the study. The training groups had 3 training sessions per week, in the first week, each session lasted for 30 minutes, and in the eighth week, it was changed to 45 minutes of walking without rest with an intensity equal to 50 to 70% of the maximum reserve heart rate. Supplemental groups consumed 5.7 grams of purslane capsules after lunch and dinner daily. The control group was not subjected to any training or supplements during the 8 weeks. Correlated t-test was used to examine intra-group differences, and analysis of covariance was used to examine inter-group differences at a significant level of P<0.05 using SPSS version 26 software.

The results of covariance analysis showed a significant difference in lipid profile values and fasting sugar levels in the three experimental groups compared to the control group (P<0.05).

Probably, the consumption of Portulaca oleracea seed supplement and aerobic exercise improves the lipid profile and fasting sugar in middle-aged men with type 2 diabetes. Therefore, it is recommended for middle-aged men with type 2 diabetes on the verge of obesity to take purslane seed supplement and aerobic exercise.

Exercise training and some supplements, such as Nigella Sativa, significantly change inflammatory factors and fat percentage. The present study aims to determine the effects of four weeks of aerobic exercise and the use of Nigella Sativa Oil Supplementation separately or together on fat percentage and C-reactive protein inflammatory index in inactive women. This semi-experimental research was conducted in the form of pre -post-test and the field method. For this purpose, 40 inactive women were selected and randomly divided into four equal groups, including exercise-supplement, exercise-placebo, supplement, and control. Aerobic exercises during four sessions and Nigella Sativa Oil Supplementation in the form of a 1000 mg capsule were given daily after lunch. Fat percentage and CRP were measured before and 48 hours after the last exercise and supplementation protocol. Statistical analysis was performed by paired t-test and analysis of covariance at a significance level of p<0.05. Covariance analysis showed a significant decrease in CRP levels (p<0.001); also, a significant difference was observed between the control group and the experimental groups and between the placebo group and the exercise-supplement and supplement groups (p<.0/05). The intragroup results indicated a significant decrease in CRP in three experimental groups before and after four weeks of training and supplementation (p<0.01). The difference in fat percentage between groups was not significant. There was a significant decrease in fat percentage in the placebo group before and after four weeks of training and supplementation (p<0.05). It is recommended to use the black seed oil supplement alone and in combination with aerobic exercise to improve the effect of aerobic exercise in reducing inflammatory injuries. In order to have a better effect of aerobic exercise in decreasing inflammatory injuries, Nigella Sativa Oil can be used alone and in combination with aerobic exercise.

Nowadays, osteoporosis is increasing, especially in postmenopausal women, due to hormonal changes, including some enzyme factors, such as alkaline phosphatase and blood calcium levels. Therefore, this research aimed to investigate the effect of eight weeks of water exercise with Elaeagnus angustifolia supplementation on alkaline phosphatase and calcium serum levels in overweight and obese postmenopausal women.

The current apply quasi-experimental study 42 postmenopausal women living in Qazvin province, Iran, with a mean age of (52.97±5.08) years, a mean weight of (73.95±8.09) kg, and a mean height of (156±5.76) cm, were selected. Then, they were randomly divided into four groups: control (n=10), exercise + placebo (n=10), supplement (n=10), and exercise + supplement (n=12). The exercise included eight weeks of water exercise at an intensity of 60-74% of the maximum heart rate twice a week, and the supplement group received daily oral supplementation of 15 g. Blood samples were collected to measure the serum level of alkaline phosphatase with an ELISA kit and calcium with spectrophotometry method in two stages before and 24 h after the last session exercise. To analyze the differences between groups and within groups, the ANOVA test and paired t-test were used, respectively. The significance level was considered at α=0.05.

 The results of the study showed a significant difference only in serum calcium levels among exercise+placebo (P=0.013), exercise+supplement (P<0.001), and supplement (P<0.001) groups. No significant difference was observed in the other parameres between different groups.

Consumption of supplementation of Elaeagnus angustifolia with water exercise could not affect alkaline phosphatase, and body composition in overweight and obese postmenopausal women.

The aim was to investigate the effect of eight weeks of Pilates training and Celery seeds supplementation on serum CRP and ESR level in middle-aged women with rheumatoid arthritis.

40 women with rheumatoid arthritis referred to Shariati Hospital in Tehran (age: 53.10±5.35 years, weight: 62.37±5.93 kg) were randomly divided into Control (n=10), Training and Placebo (n=10), Supplement (n =10) and Supplement + Training (n =10) groups. The training subjects experienced eight weeks of Pilates exercises, three sessions/week at 65% of MHR up to 60 min. the supplementation groups consumed 1.3 g Celery seeds powder three times daily for eight weeks.

in spite of serum CRP down regulation in Supplement + Training group (p < 0/05), no significant change were recorded for ESR in this group (p≥0/05).

synchronized Pilates training in accompany with Celery seeds supplementation could be beneficial in controlling inflammatory status of patients with rheumatoid arthritis. However, more investigations remain to be done because of the lack of similar evidence and also limitations in this study.

Recovery periods during intense exercise cause changes in blood flow, such as hematologic factors and Muscle Damage. The aim of present study was to evaluate the effect of different recovery in an high intensity training session changes of platelets, white blood cells and creatine kinase serum before, immediately after and two hours after exhaustive exercise in healthy active men.

In this stude, 24 healthy men (Age: 21/07± 1/57, weight: 68/41± 11/75, body fat percentage: 15/93± 6/11 and VO2max: 41/83± 5/87) were selected and randomly divided into three groups including: control, aerobic and stretching PNF recovery were studied. The blood samples were collected from anticubital venous in at pre-test, post-test and follow up. To measure the platelets and white blood cells values, Flowcytometry and equipment Mindray BC-5800 and to measure creatine kinase serum values ELISA technique was used. And to identify significant the data for the analysis of variance with repeated measures with Bonferroni post hoc tests at a significance level of α=0.05 was used.

There was a significant difference about the amount of platelets, white blood cells and creatine kinase serum in different periods of pre-test, post-test and follow-up revealed(P<0.001). The Bonferroni Post-hoc test results showed a significant difference in the control group between post-test and follow-up(P<0.05), in the PNF group between pre-test and post-test(P<0.05) and post-test and follow-up(P<0.01) and in the aerobic group between pre-test and post-test(P<0.001) and post-test and follow-up periods(P<0.01). Bonferroni post hoc test creatine kinase serum results, showed significant differences between the control group post-test and follow-up(P<0.05), PNF group between pre-test and post-test periods(P<0.05) and post-test and follow-up (P<0.01).

There was no effect of aerobic recovery and PNF stretching at rest in a HIT training session on platelets, white blood cells and creatine kinase is, but a change in values before and after training in each group. The advantage of active and passive recovery for changes in some hematological values and no Muscle Damage after an intense training.

Keyword: PNF Stretching, Exercises HIT, Platelets, White Blood Cell, Creatine Kinase Serum, Active Males

The aim of the present study was to investigate the effect of glucose supplementation on response HSP70 serum in non-athlete men after six-week exhausting endurance-intermittent training. The 18 non-athlete healthy men were randomly divided into three groups including: glucose supplementation training group (n=6) and a control group (n=6). The blood samples were collected from antecubital venous at the onset of training protocol period and after first and final training session immediately. Serum HSP70 concentration were determined by ELISA technique. Serum HSP70 values in the second posttest in three groups was 1/1 ± 8/3, 2/1 ± 9/3 and 2/1 ± 8/2 ng/ml respectively. The results Analysis of variance with repeated measures test showed the significant difference between supplement glucose-train group and placebo-train with control group(P<0.01). Also, the results showed significant difference in glucose-train between all three phases (P<0.01). Bonferroni post-hoc test showed the significant difference between pretest with post(1) and post(2) and post(1) with post(2) phase(P<0.05). Also, showed significant in train-placebo between all three phases (P<0.05). Bonferroni post-hoc test showed the significant difference between pretest with post(1) and post(1) with post(2) phase(P<0.05). Exhaustive exercise on glucose utilization adaptation with the response of HSP70 more effective than exercise alone is exhausting endurance-intermittent exhausting endurance-intermittent training with consumption glucose causes adaptation in response HSP70 than exhausting endurance-intermittent training

None-glucose substrates such as ketone bodies and lactate play an important role in sustaining the brain energy need in diabetes and obesity states. The aim of this study was to investigate the effect of endurance training on lactate transports gene expression in the brain of healthy and diabetic rats. Thirty five eight-weeks-old male Wistar rats were randomly divided into four groups; control (n=7), trained (n=8), diabetic control (n=10), and trained diabetic (n=10). Diabetes was induced by the intraperitonealinjection of streptozotocin, and 8weeks ofendurance training was applied on trained groups. Relative gene expression of MCT1, MCT2 and MCT4 expression in the cortex, hippocampus, and cerebellumwere measured by Real-time PCR,and gene expression was quantifiedby 2-∆∆CT method. The differences of variables between groups were tested using Analysis of variance (ANOVA) and Tukey’s post-hoc testwere used to determine wherever significant differences occurred. Diabetes induction increased MCT1 gene expression in the cortex (1.91-fold) and MCT2 in the cortex (1.98 - fold), hippocampus (1.7-fold), and cerebellum (2.52 - fold) in the diabetic control as compared to the control group. There was a significant difference regarding MCT1 gene expression between the diabetic control and the trained diabetic (P<0.05). MCT2 gene expression in the cortex (P<0.05) and cerebellum (P<0.05) were significantly different between the diabetic control and the trained diabetic.Discussion & The results of this study showedthat diabetes and exercise-induced changes in the lactate transporters gene expression were occurred in order to protection of the brain lactate uptake.

The aim of the present study was to investigate the effect of glucose and glutamine supplementation on serum HSP72, in non-athlete men during four weeks exhaustive endurance - intermittent training that causes glycogen depletion. For this purpose 20 non-athlete healthy men were selected and randomly divided into four groups including: glucose supplementation with glycogen depletion training group (n = 5, supplement 1), glutamine supplementation with glycogen depletion training group (n = 5, supplement 2), glycogen depletion training group (n =, placebo) and a group without any treatment (n = 5, control). The blood samples were collected at the onset of training protocol period and 48 hours after final training session from anticubital venous. Serum HSP72 concentration were determined by ELISA technique. The main and interaction effects of variables were determined using TWO WAY ANOVA compeleted with Tukey post-hoc test. The significant level was chosen as α = 0.05.The results showed the significant effect of training variable for serum HSP72 concentration, [F(1,17)= 6.362 P<0.05]. The effect of supplementation variable was significant for serum HSP72 concentration, [F(1,17)= 15.362 P<0.01]. Post-hoc test showed the significant difference between placebo with supplement 1 group (p<0.05) and placebo with supplement 2 group (p<0.01). The interaction effect between two variables was not significant. In summery, the results suggested that in glycogen depletion training condition, glucose or glutamine supplementation have significant effect on serum HSP72 concentration.