علیرضا امیرآبادی

Metabolic thyroid disease is one of the most common diseases in adults. On the other hand, environmental pollutants, including heavy metals, can interfere with hormonal function. So, the aim of this study was to evaluate the serum level of magnesium, manganese, and selenium in patients with hypothyroidism, hyperthyroidism and thyroid cancer in South Khorasan in 2018.

In this study, 77 patients were evaluated in three groups: hypothyroidism (n=33), hyperthyroidism (n=33) and cancer (n=11). After receiving the consent of the patients, their demographic information were collected. Sampling was convenient sampling method. Then, 10 ml of venous blood after 12 hours of fasting were taken. After the serum preparation, the levels of trace elements were assayed by ICP-MS.

The mean level of the studied metals (except for manganese) were not significantly different in the three groups (p> 0.05). The level of magnesium, manganese, and selenium in the hypothyroidismwere 1.74±0.55, 6.30±4.88, and 1.38±0.80; in the hyperthyroidism were 1.77±0.41, 5.55±4.55, and 1.47±0.70; and in the thyroid cancer group were 2.07±0.81, 6.02±2.22 and 1.84±1.03 respectively (p< 0.05).

According to the findings of this study, the changes in the trace element status can lead to a type of thyroid disorder, or even these disorders may alter the serum levels of these metals. But this difference, except for manganese metal, was not significant in other cases, however, further studies with other metals and elsewhere are recommended.

Within the past few years out breaks of cholera has occurred in different points of Sistan and Baluchestan province of Iran, especially in the Zahedan district. The objective of this study was definition of the most important routs of transmission of cholera in the rural areas of Zahedan district involved in the cholera outbreak of summer 2003. The outbreak lasted for about 1.5 months. Methods and Materials: A case-control study was performed on 20 patients and 89 subjects as controls. A questionnaire was completed for every subject about individual hygiene, hygiene regulations of the family, the source of the drinkable water, use of chlorination of water, use of soap for hand washing, eating and drinking outside in feasts (such as weddings), getting ice from street vendors, and travel history. Stool culture for detection of cholera was performed for all cases and also for consent controls. In multivariate analysis age (OR = 0.8, P = 0.004), eating food in parties (OR = 34.5, P = 0.020), absence of soap in hand-washing place (OR = 4.7, P = 0.000) and household size (OR = 1.3, P = 0.002) were significantly associated with cholera. In univariate analysis, getting ice from street vendors (P = 0.032) also had relationship with catching cholera. Different routs of transmission of cholera are mentioned in reference books; however every outbreak has its own special circumstances. The most important points with regard to this outbreak were the importance of individual hygiene (especially using soap in hand washing), control of production and distribution of ice by street vendors, and the importance of eating and drinking in ceremonies even feats and weddings. Warning of people about these points may play key role in controlling a cholera outbreak.