فهرست مطالب غلامرضا وطنی

Background and aim. The balance between ROS generation and antioxidant activity is critical to the pathogenesis of oxidative stress related disorders. In this study the prooxidant – antioxidant balace and its correlation with lipid profile and uric acid was determined, to evaluate the PAB as a prognostic factor for CAD. Materials and Methods Seventy – two patients and sixty eight healthy volunteers were enrolled in this study. The values of PAB was determined by using standard solutions and ELISA method. Triglyceride, total cholesterol, LDL- cholesterol, HDL – cholesterol and uric acid were measured by enzymatic method. Results The PAB values of CAD patients and control group were 70.01±3.36 (HK unit) and 66.40 ± 2.84 (HK unit) respectively. There was no significant difference between PAB values among two groups (P= 0.41). There was no significant difference between uric acid levels among two groups (P= 0.46). There was a significant correlation between the uric acid values among patients and healthy volunteers and PAB values (P <0.01). There was a significant correlation between the TG, chol LDL, HDL HDL values among patients and healthy volunteers and PAB values (P<0.05). Discussion and conclusion This study showed, oxidative stress could be used as a significant risk predictor in the coronary artery disease patients.

The balance between ROS generation and antioxidant activity is critical to the pathogenesis of oxidative stress related disorders. In this study the prooxidant - antioxidant balance and its correlation with lipid profile and uric acid was determined to evaluate the PAB as a prognostic factor for CAD. Seventy - two patients and sixty eight healthy volunteers were enrolled in this study. The values of PAB were determined by using standard solutions and ELISA method. Triglyceride, total cholesterol, LDL- cholesterol, HDL - cholesterol and uric acid were measured by enzymatic method. The PAB values of CAD patients and control group were 70.01±3.36 (HK unit) and 66.40 ± 2.84 (HK unit) respectively. There was no significant difference between PAB values among the two groups (P= 0.41). There was no significant difference between uric acid levels among the two groups (P= 0.46). There was a significant correlation between the uric acid values among patients and healthy volunteers and PAB values (P <0.01). There was a significant correlation between the TG, values among patients and healthy volunteers and PAB values (P<0.05).Discussion and This study showed oxidative stress could be used as a significant risk predictor in the coronary artery disease patients.