فاطمه سادات ولی زاده

The savory(Satureja macrantha) belongs to the mint family, it is an annual or multi-year plant, Iran has 12 annual or multi-year grass species. In many studies, antimicrobial, antiviral, antifungal, antispasmodic, stomach strengthening and digestion facilitating properties of this genus have been reported. Nisome is a important surfactant-based non-ionic vesicle. Niosomes offer several advantages for drug delivery systems, including osmotically active, chemical stability and long retention time compared to liposomes. In the present study, niosomes extracted from as a drug are dynamically evaluated by calorimetric method (Folin's method). In this study niosomes formulation containing Satureja macrantha extract, in order to achieve the optimal formulation, different formulations were prepared based on the molar ratio of Span 60/Tween 60, cholesterol and with a sonication time of 7 minutes. The niosomes extracted from the savory plant significantly inhibited the activity of the two bacteria(Staphylococcus aureus ) and (Escherichia coli) tested in the present study.