فهرست مطالب محسن شهسواری

To evaluate the efficacy of intravitreal bevacizumab for the treatment of type 1 retinopathy of prematurity (ROP) in zone I.

Preterm infants with type 1 ROP in zone I (zone I ROP, any stage with plus disease or zone I ROP, stage 3 without plus disease) were enrolled in this prospective study. Intravitreal bevacizumab (0.625 mg/0.025 ml) was injected under topical anesthesia. The patients were followed-up weekly for 4 weeks and, then, biweekly till 90 weeks gestational age.

Seventy eyes of 35 patients with type 1 ROP in zone I were enrolled. At a gestational age of 90 weeks, ROP regressed with complete or near‑complete peripheral retinal vascularization, in 82.9% of eyes after a single injection and in 92.9% of eyes after up to two injections. In 5 eyes (7.1%), ROP progressed to stage 4B or 5, so that surgical management was required. There were no major complications such as endophthalmitis, cataract, or vitreous hemorrhage after injection.

Intravitreal bevacizumab injection is an effective method for the management of patients with Zone I ROP requiring treatment; however, some cases may progress to more advanced stages and require surgical management. Close monitoring for recurrence or progression is necessary. Eyes with persistent zone I ROP may progress to advanced stages when treated with intravitreal bevacizumab injection and re‑treatment may be needed.  

Many studies have investigated the effects of psychological factors on disease activity in patients with ulcerative colitis (UC). However, the number of studies that have assessed the correlation between immunologic markers of UC and psychological distress are few. Therefore, we designed a study to determine the association between two immuno-biological markers, peripheral/central anti-neutrophilic cytoplasmic antibodies (c-ANCA and p-ANCA), and depressive symptoms, healthy anxiety and personality traits.A total of 108 patients with UC entered the study. p-ANCA and c-ANCA were determined by enzymelinked immunosorbent assay (ELISA) and reconfirmed by indirect immunofluorescence. Severity of UC was classified based on Truelove criteria. Depressive symptoms were measured by the Center for Epidemiologic Studies-Depression (CES-D) Scale, anxiety symptoms by the Hospital Anxiety Depression (HAD) Scale and personality traits were assessed by the Revised Eysenck Personality Questionnaire. Pearson correlation was used to assess the relationship between p-ANCA/c-ANCA and psychological distress. Our results showed that 81.5% of the patients suffered from anxiety, 43.5% suffered from depression and 75% suffered from introvert personality. No patient was positive for p-ANCA. There were 16 patients (14.8%) who tested positive for c-ANCA; 85.2% were negative for c-ANCA. Anxiety was significantly higher in the c-ANCA negative patients. According to our results, only testing negative for c-ANCA correlated with anxiety. However, the high prevalence of anxiety, depression and introversion and their roles in the clinical course and outcomes of the UC shows the need for early psychological intervention in those patients.

Background and There are several studies that hypothesize presence of a connection between psychopathological status and creativity. Ïn this study we compare the creativity and intelligence quotient in bipolar parents and their offspring (all euthymic) with healthy control group and their offspring. Twenty patients with bipolar disorder and twenty of their offspring (all euthymic) matched for sex، age، socioeconomic and educational levels together with twenty normal control subjects and twenty of their offspring were recruited. Âll participants completed creativity randsyp questionnaire (an objective measure of creativity) and Wechsler adult intelligence scale test sheets. Mean scores on these instruments were compared across groups. Bipolar parents showed significant decrease on Wechsler adult intelligence scale (p<0. 05) compared with healthy control parents. Total intelligence quotient scores of bipolar offspring and healthy offspring of healthy controls showed significant difference. Çonclusion: We found that bipolar disorder patients and healthy control subjects had similar creativity on creativity randsyp questionnaire. Ïn Çontrast to some studies، we did not find high creativity in bipolar offspring، of course there was important limitation in our study: all case and control groups had low socioeconomic and low education and might have it caused these results. Ïntelligence quotient scores were lower in bipolar parents than healthy control subjects. We also conclude that bipolar disorder maybe associated with significant and persistent cognitive impairment. Ïntelligence quotient may also be affected at least in some recovered bipolar patients.