فهرست مطالب محمد مهدی حیات بخش عباسی

Celiac disease is a common malabsorptive bowel disease caused by gluten sensitivity that affects other organs of the body in addition to the gastrointestinal tract, such as the liver, brain, and respiratory system. In this study, we aimed to evaluate the pulmonary volumes in patients with celiac disease in Kerman city.

This cross-sectional descriptive study was performed on all adult patients with celiac disease in the Celiac Registry in Afzalipour Hospital. All patients whose records were complete were included in the study. At this stage, height and weight were measured, and their demographic information was recorded in a checklist. Then, according to the standard conditions, spirometry was performed. Data were analyzed using SPSS software version 22.

The study cases comprised 58 patients with celiac disease. The average age of the patients was 37.59±18.02 years. The mean height was 157.22±14.30 cm and the mean weight was 57.09±17.06 kg. The results showed that the mean forced vital capacity (FVC) was 3.15±0.93 L, the mean forced expiratory volume in 1 second (FEV1) was 2.68±0.76 L, the mean ratio of FEV1 to FVC 83.06 ± 5.56%, and the mean of peak expiratory flow (PEF) was 6.64±1.61 L.

The results of this study indicated pulmonary volumes in celiac patients were lower than the normal age- and sex-matched population. Further studies to follow up and assess respiratory problems in these patients are needed.

One of the most important criteria of the development of countries at the national and international levels is the survey of scientific productions indexed in authentic databases. This study aimed to analyze the scientific productions by Iranian researchers on gastroenterology and hepatology in the Web of Science (WOS) database.

This applied study used a scientometric approach to review the scientific productions by Iranian researchers on gastroenterology and hepatology in the WOS database. Therefore, the total number of scientific documents related to the category of gastroenterology and hepatology, Iran, and other countries were recovered. The time frame was until the end of 2017. Data were collected in April 2018. This research was conducted at the Clinical Research Unit in Afzalipour Medical Center in Kerman, Iran.

The results showed that during 1983 to 2017, the total number of 2180 scientific productions (0.31%) on gastroenterology and hepatology were published in Iran, ranking the country 34th in the world. Compound annual growth rate (CAGR) in Iranian scientific publications was 9.5%. The «Tehran University of Medical Sciences» was identified as the most productive center in gastroenterology and hepatology field with a contribution rate of 35.69%. The results also showed that the most international collaboration of Iranian researchers on gastroenterology and hepatology field was with the United States of America (USA) scientific centers (5.82%). Most articles in the field of gastroenterology and hepatology (26.69%) were published in the «Hepatitis Monthly» journal. Most scientific productions in this field were related to the microbiology. The majority of scientific productions on gastroenterology and hepatology field were published in the form of article. Most scientific productions by Iranian researchers on gastroenterology and hepatology in the Web of Science (WOS) database were in English language.

Results showed that although compound annual growth rate (CAGR) in Iranian gastroenterology and hepatology publications was high rather than gastroenterology and hepatology scientific productions CAGR in the world, it’s not satisfying. Most articles have published in journals with low impact factor. Therefore, we should resolve the problems and increase the scientific level of researches.

Rational prescription of medicine by physicians is one of the most important factors in the correct and complete treatment of patients. The aim of this study was to evaluate prescription writing patterns of graduating interns for common illnesses in Kerman University of Medical Sciences, Iran, in 2013.
In this descriptive, cross-sectional study, the prescription writing pattern of 50 interns of Kerman University of Medical Sciences were evaluated. A written exam assessing prescription writing on 30 common clinical cases was held. Data were analyzed using SPSS software.
The average number of items per each prescription was 2.07. The frequency of medicines prescribed by their generic name and from the World Health Organization (WHO) list of essential medicines was 96.8% and 97.1%, respectively. Drug interaction was observed in 5.6% of prescriptions. The frequency of prescriptions containing antibiotics, injectable medicines, and corticosteroids was 47.2%, 9.3%, and 6.5%, respectively. The most common groups prescribed were antibiotics and analgesics.
Based on the WHO recommended standards, the prescription of antibiotics by interns of Kerman University of Medical Sciences was irrational and inappropriate. Therefore, educational interventions are necessary to improve prescription writing patterns among interns.

Improving life is the main goal of therapeutic interventions for chronic diseases. although we needed to determine quality of life by various variables. This study aimed to determine quality of life in patients with Irritable Bowel Syndrome (IBS) in Kerman. This is a cross sectional study of 143 patients with IBS referred to a specialist, assessed by IBS-QOL.34. Data analyzed by descriptive statistics, Pearson correlation coefficients, t-test and ANOVA, using SPSS software. p.Value <0.05 was considered as statistically significant. In this study from 143 samples, 82 were females (57.3%) and 61 males (42.7%). Quality of life score in patients was 37.16 ± 16.72, and there was significant difference in terms of employment and education level (p.value<0.05). Among patients with IBS, quality of life is far from desired. Therefore, health care providers should consider psychosocial support alongside medical management for achieving better quality of life in these patients.

Chronic constipation is a common problem worldwide that negatively impacts quality of life. Because of the effects of psychological and cultural factors on the function of the bowel tract and the vast variety of ethnicities and diet among the Iranian people، the present study describes the occurrence of constipation and its associated factors in Kerman، the largest city in Southeast Iran. This was a cross-sectional study conducted in Kerman، Iran from 2011 to 2012 that included 2191 adults who were randomly selected and interviewed face to face using a validated questionnaire based on Rome III criteria. Demographics، cigarette smoking، opium dependence، amount of fiber consumption، physical activity and psychological factors were assessed. Inclusion criteria was ages 15 to 85 years old. Exclusion criteria was the presence of any metabolic and/or neuro-muscular disease that caused constipation. All data were analyzed with Stata11 software، with a confidence interval of 95%. A p-value of ≤0. 05 was chosen for statistical significance. Particiants had a mean age of 44. 9 ± 16. 2 years. There were 57. 42% female participants. The prevalance of chronic constipation was estimated at 9. 4% (7. 7%-10. 6%). Constipation was more prevalent in females، older individuals، those with decreased physical activity، people who were anxious and depressed، and opium addicted individuals (p<0. 05). There was no significant difference in terms of cigarette smoking and amount of dietary fiber between constipated and non-constipated individuals (p>0. 2). Although the prevalance of constipation in Iran is estimated to be lower than Western countries، new changes in life style can cause an increase in the burden of constipation in the future.

Backgrond: Drug abuse, especially opium abuse, is a major public health problem in Iran. Recent reports suggest that opium sellers cheat their customers by adding lead to the opium. Contaminated opium can threaten the health of consumers. The present study aimed to compare the serum level of lead between opium dependents and a control group. This was a cross-sectional study in which 50 opium dependents aged 20 to 60 years old were compared with a control group of 43 non-dependents who were matched with the case group in terms of sex and age. The serum level of lead and liver function tests including serum total bilirubin, AST, ALT, Alkaline-phosphatase and hemoglobin were measured for all subjects. The mean level of serum lead concentration in opium dependents and controls was 3929.358 ± 147.67 and 3532.721 ± 1141.53, respectively and the difference was not statistically significant. There was no significant correlation between serum level of lead and age, duration of opium dependency, serum total bilirubin, hemoglobin, AST, ALT, and Alkaline-phosphate. Although there was no significant relationship between opium consumption and serum level of lead, the concentration of lead in dependent's serum was higher than controls. Further studies are needed to approve this relationship to be used for screening and on time diagnosis of opium dependents.

Some of plants are used as analgesic in traditional medicine. The aim of this investigation was to evaluate the analgesic effects of colchicum szovitsii Fisch and C.A. Mey that has been used traditionally to relieve the pain. The plant specimen was collected from Jupar, and then identified and nominated by a botanist. The dried bulbs of the plant was powdered and extracted by Percolated method and then concentrated by rotatory evaporator and oven. Different doses of methanolic extract of the plant was injected into male albino mice (20-25g) and its analgesic effect was evaluated by Hot-plate and formalin test. The results showed that all doses of extract, induce significant analgesia (p<0.01) in Hot plate test. The dose of 200 mg/kg of extract, induced toxic effect such as diarrhea and lethargy in mice. The results showed that, the doses of 50 and 100 mg/kg of extract, induced significant antinociception compared to the control group in all time intervals after 10-15 minutes in formalin test (p<0.05, p<0.01). There was not significant differences between the analgesic effect of the most effective dose of extract (100 mg/kg), ASA(300 mg/kg) and morphine (2.5 mg/kg), in second phase of formalin test. The analgesic effect of the extract was lower than morphine (p<0.01) 15 am 30 min after injection in Hot plate test. The analgesic effect of extract was lower than ASA 15 min after injection (p<0.01) but was higher than ASA 60 min after injection(p<0.05). Pretreatment of animals with naloxone 4mg/kg, subcutaneously, five minute before extract injection, decreased the analgesia induced by extract in all times of hot-plate test (p<0.01) except 15 min. Naloxone decreased the analgesic effect of extract in formalin test(p<0.01), except in time intervals between 5-10, 10-15 and 25-30 min. The results show that, the methanolic extract of colchicum szovitsii has a significant analgesic effect in formalin and Hot plate test and the opioid receptor may be involved in the analgesic effect of this plant. The results of this investigation could be used for more studies to access a better results.