مسعود صدرالدینی

Gastro esophageal reflux disease (GRED) is one of the most common digestive disorders. The relationship between H. Pylori infection and blood groups has been demonstrated. Frequency of blood groups was investigated in many gastrointestinal diseases. Since there is no considerable information about the relationship between blood groups and gastroesophageal reflux, in this study we examine the frequency of ABO and Rh group system with gastroesophageal reflux. In this analytic-descriptive study, patients with gastro esophageal reflux disease that attended in Urmia Imam university hospital digestive clinic after verifying the reflux (pyrosis three times a week for more than three months) enrolled in study and after determining age and sex referred to the laboratory for determining the ABO blood group and Rh factor. Collected data from the blood groups, Rh, age and sex convert to the numerical codes and compare with frequency of blood groups in west Azarbaijan. In this study 175 patients, 92 male (52.6%) and 83 female (47.4%) have been studied. Mean age of patients was 39.14±12.99 years. Seventy two patients (41.1%) were A+, 2 (1.1%) patients were A-, 27 (15.4%) were B+, 3 (1.7%) were B-, 12 (6.9%) patients were AB+, 1 patient (0.6%) was AB with negative Rh and 49 patients (28%) were O+ and 9 patients (5.2%) were O- blood group. Among 34000 blood donors, 11216 (33.2%) was A+, 10219 (30.2%) was O+, 19% was B+, 7% was AB+ and 1% was AB-. This study shows there is a high frequency of A+ blood group in gastroesophageal reflux patients. According to these results there is no correlation between gastroesophageal reflux disease and ABO and Rh blood group systems.

A wide variety of epidemiological studies suggest the increase in incidence of esophageal adenocarcinoma which, in turn, might be related to decrease in Helicobacter pylori prevalence, but very few studies have examined this association. The aim of this study was therefore to evaluate the relationship between H.pylori and esophageal squamous-cell carcinoma in Urmia in a period of 30 months.Subjects and In this case-control study 161 patients with pathologically proven esophageal squamous-cell carcinoma were enrolled. Subjects were cancer cases, pathologically proven to have esophageal squamous-cell carcinoma, in medical centers in Urmia in the west of Iran during a 30-months period in 2006 -2007. Control cases (168 patients (were selected from the patients who were admitted to the ophthalmology department and were matched for sex, age and history of smoking. H. pylori seropositivity was determined by ELISA, using Trinity Biptech capita measuring IgG. Data were analyzed using Chi square and Mantel Hanzel tests. The mean age of patients with esophageal cancer was 61.8)SD=13.4 (years. Sixty eight(42.2%) of patients were male and 93(57.8%(were female. In 31(19.2(% cases tumor ware located in the upper, 73)45.3(% cases in middle and in remaining 57(35.4 (%cases in the lower portion of the esophagus. A total of 69 (42.8%) and 105(62.5 (%out of 161 cases and 168 controls, respectively, had positive H. pylori infection. Subjects with positive H. pylori infections had a significantly reduced risk)OR =0.45; 95% CI =0.28-0.72; P=0.0001(of developing esophageal SCC than those without SCC. Our findings suggest that H. pylori infection may have a protective role against development of esophageal SCC in our area. Additional studies are needed to confirm these findings.

There are two kinds of ascites, cirrhotic and malignant. The conventional diagnostic method to differentiate them is paracentesis. This is an invasive and time consuming method. However, ultrasonography is an easy and available method to provide valuable results in a short period of time. The aim of this study was to evaluate gallbladder wall thickness in differentiating cirrhotic ascites from malignant ones. In our study, gallbladder wall thickness was measured by ultrasonography (3.5-5 MHZ curve linear ultrasound probe) in 100 patients with portal hypertension induced ascites and in 100 patients with peritoneal carcinomatosis induced ascites. The mean gallbladder wall thickness was 3.9±0.6 mm in cirrhotic patients and 2.2±0.6 mm in non-cirrhotic patients. Gallbladder wall thickening was significantly more frequent in patients with cirrhotic ascites than in patients with non-cirrhotic ascites (p‹0.001). This study revealed that the ultrasound finding of gallbladder wall thickening in patients with ascites could be highly predictive for portal hypertension induced ascites.