فهرست مطالب مصطفی کاظمی بودانی

In this study the radioiodination process of meta-iodobenzylguanidine with 131I isotope in presence of ammonium sulphate and Cu(II) Catalyser was investigaded. In order to optimize the process, the influence of different parameters on labeling yield was studied. The results of experiments showed that the use of oil bath with temperature of 160˚C is necessary. After the labeling process, purification step of the final product was carried out using Dowex-1x8 resin. The mean labeling yield was 97.2%. In this method radiolabelling of MIBG with 131I (185 MBq for diagnostic dose and 3330 MBq for therapeutic dose) is quite simple and it complies with the requirements of routine production of 131I-MIBG radiopharmaceutical for diagnostic and therapeutic purposes. This paper is a narration of industrial scale production of 131I-MIBG radiopharmaceutical.

Zirconium molybdate gel has an excellent characteristic to be used as a column matrix material of 99mTc generators. The preparation conditions of zirconium molybdate gels will directly influence their physico-chemical characteristics and thus generator performances. In this work a series of zirconium molybdate gels were synthesized under different conditions and characterized by ICP, TGA, XRD and SEM Techniques. The effects of different parameters including pH of molybdate solution, Zr:Mo molar ratios, order of reactants addition, washing and granulating of gel on the performance of technetium-99m generators were evaluated. The experiments show that the optimum conditions for synthesis of the gel consist of: pH=4-4.5, Zr:Mo ratio of 1:1, gradual addition of molybdate solution to zirconium oxy chloride solution, no washing and grinding the resulted gel.