کامبیز ولیی

Gastric ulcers are created by various reasons. Faster healing of wounds is more challenging to researchers. The aim of this study was to histopathgological evaluation of the effect of phenytoin and theranekron-impregnated polyglactin 910 yarns on healing process of gastric surgical wound in the rabbits. Twenty-one male white Newzland rabbits were divided into three groups of control, phenytoin and theranekron. A gastrotomy incision with one cm in length was made in the greater curvature of the gastric wall, and then was sutured in Cushing pattern with phenytoin and theranekron-impregnated Vicryl yarn. For histopathological evaluation at days 3, 7 and 21 after surgery tissue samples were taken and stained with hematoxylin eosin and Masson-Trichrome. Histopathological changes were analyzed by using the Kruskal-Wallis test. The results of the histopathological studies showed that in the phenytoin and theranekron groups the rate of inflammatory cells, fibroblasts and vascularization were significantly (P<0.05) lower than  the control group and rate of epithelial cell formation was significantly higher than  the control group but between phenytoin and theranekron groups were not significantly difference.

This report describes the simultaneous occurrence of fibrosarcoma and a urolith in the urinary bladder of a 12-year-old female terrier dog that was confirmed by pathology after excisional surgery. Clinical

The dog had some clinical signs such as frequent urination, hematuria and dysuria with anorexia and urinary tenesmus. Radiography confirmed the presence of a cystolith that was removed by surgery. During surgery, a solitary, pedunculated and round mass that had grown from mucosal tissue to the bladder space was observed. The mass was removed by excisional surgery and its pathologic section was prepared and stained by Hematoxylin and Eosin (H&E) and Masson’s trichrome methods. Microscopic findings in the tissue of the mass such as spindle fibroblastic cells with mild to moderate cellular pleomorphism and nuclear hyperchromasia, presence of mild mitosis figures, and chronic inflammation revealed the nature of the mass as a low-grade fibrosarcoma.

The cystolith was removed during depletion of the bladder and fibrosarcoma was removed by surgery to prevent further enlargement of the tumor and occupy the bladder space. Moreover, antibiotic therapy to avoid secondary infection was performed. Post-operation monitoring of the patient showed that there was no evidence for recurrence of the tumor within 3 months after surgery. Clinical relevance: Given the findings of this report, an occurrence of bladder fibrosarcoma has non-specific clinical signs that may challenge its differential diagnosis from other urinary-tract lesions.