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brain derived neurotrophic factor not only important in the nervous system, but also in central and peripheral molecular processes that related to energy metabolism and homeostasis. Also irisin, a novel myokine that is secreted from skeletal muscles, has an important relationship between physical activity and health. Materials &

In this study, 20 overweight men that were randomly selected and equally divided into control and experimental groups. Blood samples were taken two times, before the start of training, and final samples, 48 hours after the end of the eight-week training.

Serum Irisin levels, after the completion of combined training than pre training significantly increased. Also, BDNF levels in the training group, after acute and chronic exercise training significantly increased. But significant correlation between the concentrations of Irisin and BDNF levels of the subjects was not observed.

Serum irisin and brain-derived neurotrophic factor levels, influenced by physical activity. Irisin can cause metabolic and physiological changes within the body and play a protective role against conditions such as obesity that associated with inactivity. Likewise, brain-derived neurotrophic factor increased as a result of physical activity and also the critical role in the differentiation of neurons and mental health, do a key role in controlling body weight and energy homeostasis.

In the present study, the effect of acute aerobic exercise on enzymatic and non-enzymatic salivary antioxidants variations in non-athlete men, was investigated.
In this experimental study, 25 male non-athlete collegiates (age, 21.2±1.6 years; weight, 68.62±10.1kg; body fat, 16.75±2.9%; and Vo2 max, 37.54±2.4ml/kg/min) participated voluntarily in this study. Saliva samples were collected in three phases (before, immediately, and 1 hour after running) on treadmill according to Astrand test. The activity of peroxidase and catalase, and concentration of uric acid were measured by laboratory methods. Then, to assess the obtained changes, repeated measures statistical test, and in case of significance, post-hoc Bonferroni test were used for pairwise comparing of the measuring phases at the significance level of p≤0.05 used.
The activity of peroxidase significantly increased immediately and 1 hour after exercise compared to the baseline; Also, the concentration of uric acid significantly increased after aerobic exercise, but catalase enzyme activity significantly decreased after aerobic exercise (p According to the findings of this study, aerobic exercise causes the production of free radicals, and salivary antioxidant system increases as the body biological response to neutralize and counteract the damaging effects of free radicals.

Brain-Derived Neurotrophic Factor (BDNF) plays an important role in transmission of nerve impulses, plasticity, growth, and generally in the health of nervous system. Interleukin-6 (IL-6) is involved in immune and inflammatory responses and is produced by immune cells, fibroblasts, endothelial cells, skeletal muscles, and fat tissues. The aim of this study was investigating the changes of IL-6 and BDNF serum concentration following acute plyometric training among inactive men.
This semi-experimental study was conducted at a gymnasium in Yasuj. A total of 18 inactive men voluntarily participated in the study and were randomly divided in two groups: experimental (n=9) and control group (n=9). Subjects in the acute exercise group performed plyometric trainings consist of scissor jump, lateral hop, box jump, diagonal hop, power skipping, and speed skipping. Subject's blood samples were taken before and after training in order to measurement IL-6 and BDNF levels. The levels of IL-6 and BDNF were measured using an enzyme-linked immunosorbent assay (ELISA) kits. Between group differences and within group differences were analyzed through independent t-test and dependent t-test, respectively, using SPSS 16 software. The level of significance was considered P The levels of IL-6 after plyometric trainings significantly increased comparing with the control group, but significant changes wasn’t observed in BDNF concentrations.
Acute plyometric training did not have any effects on the serum level of BDNF as to the short period of training. However, the significant rise of IL-6 was attributed to the subject's lack of physical fitness.

The aim of this study was to investigate the effect of consuming vitamin C on the serum level of Brain-derived neurotrophic factor (BDNF) among healthy inactive young men.
In this semi-empirical study, 18 healthy inactive men were randomly divided into two groups; a group consuming vitamin C as a supplement and a control group. Subjects in consuming vitamin C group received 500 milligrams of vitamin C supplement daily for one week. The control group consumed placebo. Blood samples of participants were taken in fasting mode to measure BDNF concentration. BDNF was measured by ELISA method.
The serum levels of BDNF significantly increased one week after receiving vitamin C compared to the control group. In addition, the level of BDNF in subjects received vitamin C for one week significantly increased compared to the beginning of the investigation.
Data indicate that consuming vitamin C increased the serum concentration of BDNF in healthy inactive men.