مقالات رزومه محمود تاجبخش
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In this research, fluorescein-based chemical sensors were designed and synthesized through the Schiff base reaction to identify Cu2+ and Hg2+ cations. For this purpose, at first SP1 and SP2 sensors were synthesized and their structures were investigated and confirmed by 1HNMR and MS spectroscopy methods. Then, their properties as chemical sensors for some metal cations were investigated by fluorescence emission spectroscopy and ultraviolet-visible spectroscopy (UV-Vis). The obtained results indicated that the SP1 and SP2 acted selectively and also showed a color change for Cu2+ and Hg2+ cations, respectively. The reversibility studies in the presence of EDTA showed that the fluorescence was turned on with the addition of the extra amounts of Cu2+ and Hg2+ cations. Also, the data obtained from Job’s graph and fluorescence titration determined that both sensors form complexes with cations in a ratio of 1:1. Since the structures of both SP1 and SP2 are rigid, the fluorescence turned on with a plausible CHEF mechanism.Keywords: Chemical Sensors, Fluorescence Compounds, Schiff Base, Metal Ions, Fluorescein}
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We synthesized a series of new azo-based sulfonamides 8a-l via multistep chemical processes including chlorosulfonation, nucleophilic substitution, diazotization, and coupling reactions. The synthesized compounds were characterized using various physical and spectral techniques such as melting point, IR, 1H- and 13C-NMR, Mass, and elemental analysis. We evaluated the antibacterial and anticancer activities of compounds 8a-l. The cytotoxicity of these compounds was assessed on the MCF-7 breast cancer cell line and the MCF-10 human normal cell line after 48 h exposure. Notably, compound 8h demonstrated significantly higher cytotoxicity against MCF-7 (IC50 = 0.21 µM) while showing minimal toxicity towards the MCF-10 human normal cell line. To gain insights into the molecular interactions, we utilized molecular docking to predict the binding affinity of these compounds to the FGFR2 kinase receptor structure (PDB ID: 4J98). Compound 8h exhibited the highest docking score, consistent with our experimental results and demonstrating favorable protein-substrate interactions. In addition, we performed ADME prediction of the compounds, indicating their potential as lead drug candidates. Furthermore, we evaluated the antibacterial activity of compounds 8a-l against Gram-positive and Gram-negative bacteria. Compound 8i showed the strongest antibacterial activity against Staphylococcus aureus, a Gram-positive pathogen. This study provides valuable insights into the biological activities of azo-based sulfonamide derivatives, establishing their potential as both anticancer agents and antibacterial compounds.Keywords: Azo-Based Sulfonamide, Sulfonamide, Breast Cancer, Molecular Docking, Cytotoxicity, Antibacterial}
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The surface of bio-synthesized TiO2 nanoparticles was modified with a silane agent to generate the chemical link to the preparation of TiO2/β-cyclodextrin and TiO2/Ag/β-cyclodextrin nanocomposites. The structure of synthesized nanocomposites was identified using different techniques, including FTIR, DRS, XRD, ICP, TGA, FESEM, and EDX MAPPING. The photocatalytic activity of the nanocomposites was investigated in the degradation of methylene blue dye in aqueous solution under sunlight irradiation (400-700 nm). The effective factors in the degradation of methylene blue dye including, nanocomposite dosage, initial methylene blue concentration, and irradiation time were studied. The results revealed that under optimum degradation conditions (0.01 g nanocomposite, initial methylene blue concentration of 10 ppm, and 120 min sunlight exposure time), TiO2/Ag/β-cyclodextrin exhibited the highest photocatalytic activity among the tested nanocomposites. The photocatalytic efficiency of nanocomposites showed the order: TiO2/Ag/β-cyclodextrin (99.38%)> TiO2/β-cyclodextrin (84.1%)> TiO2 nanoparticles (63.76 %). Photocatalytic activity of the synthesized nanocomposites revealed that these materials could be promising candidates for the degradation of various pollutants.Keywords: β -cyclodextrin, TiO2 nanocomposites, photocatalyst, Methylene blue, Visible light}
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The purpose of this article is to describe the synthesis of copper-amine complexes on nano NaY zeolite (Cu@NNPS-NaY), as a highly efficient, reusable, and environmentally friendly catalyst for the xanthenes synthesis. The Cu@NNPS-NaY catalyst was prepared from the reaction of silane-bonded nano NaY Zeolite (CPS-NaY) with [2-({3-[(2-aminoethyl) thio]propyl} thio)ethyl]amine (NN) followed by immobilizing copper ions onto the NNPS-NaY surface. The catalyst structure was characterized using FT-IR, XRD, TGA, EDS, DLS, SEM, TEM, ICP, and elemental analyses. The bonded long-chain amine including heteroatoms on the zeolite surface improved its catalytic activity and homogeneity, making it more capable of coordinating with copper ions. Synthesis of xanthenes was performed in the presence of Cu@NNPS-NaY catalyst (30 mg) in EtOH (10 mL) at 60 °C within 10-60 minutes resulting in product yields of 84-97%. The prepared catalyst can be easily recovered by centrifugation and reused for at least twelve consecutive runs with no significant loss of its catalytic activity. Besides the simplicity of catalyst recovery and reusing, the method is easy to set up and versatile, making it an environmentally friendly way to prepare titled heterocycles. Based on the results of this study, other useful heterocycles could be synthesized under eco-friendly conditions using this catalytic system.Keywords: Heterogeneous catalyst, Copper - amine complex, Xanthenes, Amine-modified NaY zeolite, Heterocyclic compounds, Green chemistry}
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Iranian Journal of Chemistry and Chemical Engineering, Volume:40 Issue: 2, Mar-Apr 2021, PP 581 -592In the current research, NaY zeolite with a molar ratio of Si/Al=2.5 was grafted chemically with amines like monoethanolamine, tetraethylenepentamine, and morpholine.The modified NaY zeolites were characterized by XRD, FT-IR, TGA, EDAX, BET, FESEM, CO2-TPD, and Volumetric analysis. Modification of the NaY surface with amine groups led to a remarkable rise in CO2 adsorption capacity. CO2 adsorption studies of NaY and modified NaY zeolite by CO2-TPD technique revealed that, the dominant mechanism involves the interaction of CO2 with amine groups on the surface of NaY zeolite, at ambient pressure and at a temperature of 323 K. The volumetric method was also used to investigate CO2 adsorption onto the amine grafted NaY zeolite at 5, 7 bar pressures and at temperatures of 298 and 343 K. The adsorption process is thermal dependence and results of adsorption studies indicate that increasing temperature leads to higher adsorption of CO2 onto the amine grafted NaY zeolites.Keywords: CO2-TPD, monoethanolamine, Tetraethylenepentamine, Morpholine, Amine grafted NaY zeolite, CO2 capture, Volumetric method}
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سابقه و هدف
وشا یک گیاه مونوکارپیک (تک زاد) است که بومی مرکز ایران است. حضور سسکویی ترپن ها در صمغ گیاه، نقش دفاعی مهمی در برابر قارچ ها و باکتری های بیماری زا ایجاد می کند. هدف از مطالعه حاضر ، ارزیابی فعالیت آنتی اکسیدانی و ضد باکتریایی اسانس و عصاره های اتیل استات ، کلروفرم ، هگزان و متانولی و اسانس صمغ وشا و همچنین تعیین ترکیبات موجود در اسانس است. با توجه به این که شرایط اقلیمی بر بیوسنتز متابولیت های ثانویه تاثیرگذار است، در این تحقیق عصاره صمغ گیاه وشای موجود در منطقه ی شاهرود از دیدگاه فیتوشیمیایی مورد بررسی قرار گرفت.
مواد و روش هااسانس صمغ گیاه وشای جمع آوری شده از اطراف روستای طرود شاهرود با استفاده از GC و GC / MS مورد تجزیه و تحلیل قرار گرفت و عصاره گیری با استفاده از دستگاه سوکسله با استفاده از حلال های با قطبیت مختلف از جمله هگزان ، کلروفرم ، اتیل استات و متانول انجام گرفت. ارزیابی فعالیت آنتی اکسیدانی اسانس به همراه عصاره های اتیل استات ، کلروفرم ، هگزان و متانولی صمغ دورما آمونیکوم با استفاده از روش DPPH و غربالگری ضد باکتریایی با استفاده از روش انتشار دیسک دیفیوژن و میکروبراث دایلوشن انجام شد. حداقل غلظت مهار کنندگی (MIC) و حداقل غلظت میکروب کشی (MBC) در برابر تعدادی از باکتریها اندازه گیری شد.
یافته هانتایج تجزیه واریانس نشان داد که عصاره اتیل استات با IC50 = 69.0 میکروگرم بر میلی لیتر دارای بالاترین فعالیت آنتی اکسیدانی و اسانس صمغ با IC50 = 166.0 میکروگرم بر میلی لیتر دارای فعالیت آنتی اکسیدانی متوسطی می باشد. عصاره های متانولی (25/31 میکروگرم بر میلی لیتر) و کلروفرمی (50/62 میکروگرم بر میلی لیتر) فعالیت ضد باکتری خوبی از خود نشان دادند. آنالیز اسانس اولیوگام رزین گیاه به وسیله ی دستگاه GC-MS منجر به شناسایی 51 ترکیب شد. عمده ترین این ترکیبات شامل، متیل اولیات (%2/20)، متیل پالمیتولیات (%9/15)، فنچیل استات (%25/7)، متیل لینولیات (%87/6)، متیل استیارات یا متیل اکتادکانویات (%64/6)، اولیک اسید (%97/4)، پنتادکان (%14/3)، آلفا- گیورجیونن (%66/2) و بتا- بیسابولن (%6/2) می باشند.
نتیجه گیریآمونیکوم به عنوان یکی از مهم ترین گونه های جنس دورما است. وجود ترکیبات تایید شده، فنولی و پلی فنولی موجود در عصاره یا اسانس و همچنین حضور ترکیبات سسکویی ترپن کومارین ها / فنل ها در عصاره اولیوگام رزین که باعث فعالیت زیست شناختی نظیر آنتی اکسیدانی و ضد میکروبی و حتی ضد آلزایمر عصاره های صمغ گیاه دورما آمونیکوم گردیده و گیاه را به عنوان کاندیدای مناسبی برای کاربرد دارویی مطرح می کند. این نتایج نشان می دهد که برخی عوامل بیرونی مانند آب و هوا ، خصوصیات خاک ، تنش حشرات و میکروارگانیسم ها ، زمان برداشت محصول ، روش تهیه گیاه و روش استخراج اسانس دورما آمونیکوم ، می توانند در ترکیب شیمیایی اسانس ها و عصاره ها نقش داشته باشند.
کلید واژگان: فعالیت های آنتی اکسیدانی, فعالیت های ضد باکتری, اسانس, دورما آمونیکوم}Background and objectivesVasha is a monocarpic plant endemic to central Iran. The sesquiterpens in the oleo gum resins of vasha display important defense role against fungi and pathogenic bacteria. The aim of the present study was to evaluate the antioxidant and antibacterial activities of essential oil as well as ethyl acetate, chloroform, hexane and methanolic extracts from the gum-resin of Dorema ammoniacum and investigating its essential oil constituents. As the biosynthesis of secondary metabolites is affected by the prevailing environmental conditions, in this study, the extracted gum of Dorema ammoniacum from Shahrood region was phytochemically characterized.
Materials and methodsOleo gum resin of vasha was collected from Shahroud (Torud) desert and essential oils were analyzed using GC and GC/MS and extraction was done using Soxhlet extractor with organic solvents of different polarity including hexane, chloroform, ethyl acetate, and methanol. Evaluation of the antioxidant activities of essential oil as well as ethyl acetate, chloroform, hexane and methanolic extracts from gum-resin of Dorema ammoniacum were done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and for the antibacterial screening disk diffusion and Broth micro dilution methods were employed. The minimum inhibition concentration (MIC) and the minimum bactericidal concentration (MBC) were measured against a number of bacteria.
ResultsThe ethyl acetate extract with IC50=69.0 μg/mL showed highest antioxidant activity and essential oil with IC50 = 166.0 μg/ml displayed a moderate antioxidant activity. The methanolic (31.25 μg/mL) and chloroformic (62.50 μg/mL) extracts exhibited high antibacterial activities. Analysis of essential oil of oleo-gum resin by GC-MS led to the identification of 51 compounds. Methyl oleate (20.2%), Methyl palmitoleate (15.9%), Fenchyl acetate (7.25%), Methyl linoleate (6.87%), Methyl stearate (6.64%), Oleic acid, trimethylsilyl ester (4.97%), Pentadecane (3.14%), alpha.-Gurjunene (2.66%), beta.-Bisabolene (2.6%) were identified as the dominant compounds.
ConclusionD. ammoniacum is one of the most important species of Dorema. The established phenolic and polyphenolic compounds in the extracts or essential oil as well as the presence of sesquiterpens coumarines / phenols in the oleo gum resin extract with biological activities such as antioxidant and antimicrobial and even anti-Alzheimer's makes D. ammoniacum plant as a good candidate for medicinal uses. These results showed that some extrinsic factors such as climate, soil properties, insect and microorganisms stress, harvest time, plant preparation procedure and the method of essential oil extraction in D. ammoniacum may affect chemical composition of the extracts and essential oils. Keywords: Antioxidant activity, Antibacterial activity, Essential oil, Dorema ammoniacum
Keywords: Antioxidant activity, Antibacterial activity, Essential oil, Dorema ammoniacum}
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