فهرست مطالب a rashidlamir

Cardiovascular disease especially atherosclerosis is one of the leading causes of death in the world. One of the important mechanisms for the prevention and treatment of this disease is the reverse transfer of cholesterol. The purpose of this study is to investigate the effect of a cardiac rehabilitation course on some key factors in reverse cholesterol transfer including expression of (Liver X receptor gene; LXR) lipid profile and (Tumor necrosis factor; TNFα) serum level in coronary bypass patients.Twenty-four male subjects who underwent bypass surgery were divided into two equal groups of central stability training group and mobilization voluntarily groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples including TNFα factors, lipids, cholesterol and LXR gene were taken 48 hours before the start of the first training session and also 48 hours after the last training session while all subjects were fasting a blood sample was taken to evaluate the desired variables. LXR gene was measured by Real-Time-PCR. Independent and paired t-test and Shapiro-Wilk tests were used to analyze the data at a significant level of 0.05.Eight weeks of cardiac rehabilitation program led to an increase in HDL, a decrease in LDL cholesterol and αTNF, and an increase in the expression of the LXR gene in the experimental group compared to the control group.Cardiac rehabilitation by improving the lipid profile and increasing the expression of LXR gene has a great effect on increasing cholesterol transfer process and reducing inflammatory factors including TNFα. which has a positive effect on the prevention of atherosclerosis and ischemia.

This study aimed to investigate the effect of eight weeks of combined exercise on CAF and some sarcopenia factors in CABG patients.

Twenty-four CABG middle-aged men participated in this study. Then, participants were randomly divided into two groups of 12-individuals of combination exercise group (mean age 54.58 ±6.47 years, height 173.04 ±3.15 cm and weight 74.75 ±6.60 kg) and control group (mean age 50.70 ±7.70 years, height 173.50 ±3.69 cm and mean weight of 76.16 ±5.23 kg). Anthropometric indices and serum CAF and IGF-1 blood parameters were prepared and analyzed before and after the training. The eight-week combined exercise program was conducted in three sessions with the supervision of cardiac rehabilitation specialists. Data were analyzed using repeated measures analysis of variance and Bonferroni post hoc test and significant level was considered less than 0.05.

In combined exercise group, serum levels of CAF and IGF-1 significantly increased in the post-test compared to the pre-test (p<0.001). Also, after exercise, serum levels of CAF (p<0.001) and IGF-1 (p=0.017) in patients in the combined exercise group were significantly higher than the control group. While serum levels of CAF (p=0.365) and IGF-1 (p=0.679) before training did not differ significantly between the two groups.

A short-term combination training in CABG patients increased CAF but no change in IGF-1 levels. Further research is needed to determine whether CAF or IGF-1 biomarkers can reflect the muscle quality of adaptation.

Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to investigate the influence aerobic interval training on expression of mesenchymal biomarkers, and tumor volume in mice with breast cancer.

In this experimental study, Thirty-two female BALB/c mice, aged 3-5 weeks (17±1g) were used. The mice were allocated to four groups: Exercise Tumor, Exercise (aerobic Interval training was performed six weeks (40 minutes) before and four weeks (30 minutes) after the induction of carcinoma with active recovery), Rest Tumor, Rest (Control- without exercise), Rest, Tumor, Exercise, (four weeks after the induction of carcinoma) and Exercise, Tumor, Rest (six weeks before the induction of carcinoma). The real-time PCR method was used to evaluate the expression of Vimentin and Twist.

The results of present study demonstrated that tumor tissue Vimentin expression in the Exercise Tumor Exercise (223.0±0.073) group decreased significantly (p= 0.0001), Also, the expression of Twist gene was significantly reduced in Exercise Tumor Exercise group (0.24±0.227) compared to control group (p=0.008). A significant decrease in tumor volume was observed in both RTE and ETE groups compared to the control group (RTR) (p = 0.0001).

Based on the results of this study, a period of interval aerobic training can decrease the expression of Vimentin، Twist and decrease the tumor volume ratio.

SIRT1 and PGC-1α are two factors that increase the body's antioxidant capacity, which can improve inflammation and free radicals in obesity. The present study was conducted to determine the effect of eight weeks of water training on SIRT1, PGC-1α and body fat percentage in obese men. In this quasi-experimental study, obese men (BMI = 30, waist-to-height ratio (WHtR) > 0.5) were selected voluntarily and were randomly divided into two groups of water training (n = 11) and control (n = 11). The training program included three sessions per week for eight weeks with training intensity of 60 to 80% of maximal heart rate. BMI, body fat percentage and weight of subjects were examined before and after the intervention. Arterial blood samples were used to measure SIRT1 and PGC-1α during the pre-test and post-test stages. FINDINGS: The assessments showed that PGC-1α levels increased from 7.7 to 8.7 and SIRT1 levels increased from 11.3 to 12.6, and this increase was significant in the training group compared to the control group (p < 0.001). The results showed that body fat percentage decreased from 30.2 to 27.83 and weight decreased from 94.7 to 92.2, which was significant compared to the control group (p<0.001). Based on the results of this study, water training can increase the levels of SIRT1 and PGC-1α and decrease weight and body fat percentage.