فهرست مطالب abdolnaser mohebi

In this study, a controlled release drug delivery system loaded with piroxicam and methadone was synthesized and used subcutaneously in rat with experimental tibial defect and healing were assessed histopathologically.

For this purpose 100 adult female rats were were randomly divided into five equal groups; group control, chitosan group, piroxicam group, methadone group, and piroxicam-methadone group. The morphological structure of the synthesized drug systems was studied by scanning electron microscope. In addition, the structure of the hydrogels was investigated by fourier transform infrared spectroscopy and while releasing the hydrogels gelation time, the release of piroxicam and methadone from the hydrogels were evaluated in vitro.  

 Histological results of the 3rd day of the study showed the lowest extent and severity of inflammation in the chitosan, piroxicam, and piroxicam-methadone groups, while on the 7th day, tissue inflammation and the extent of bleeding was lower in the piroxicam, methadone, and piroxicam-methadone groups than in the other groups. Evaluation of new bone formation on day 21 showed that the chitosan, piroxicam, and methadone groups had better repair than the other groups.

It seems that in the control group that did not receive any treatment intervention, following the experimental bone defect, the highest inflammatory response was observed in histological examination and finally the weakest bone repair. On the other hand, the presence of piroxicam, methadone and chitosan in the piroxicam-methadone group (all of which have anti-inflammatory effects) also seems to have a negative effect on repair.

With regard to the importance of prescribing medicinal plants in the traditional veterinary medicine and the anti-inflammatory role of ginger, the current study was conducted to evaluate the effects of the oral administration of the ginger rhizome powder following ovariohysterectomy in puppies. Ten healthy young female puppies were randomly assigned to two equal groups, including a control and an experimental group. Two hours before surgical neutering by ovariohysterectomy, a Zintoma Capsule (Zingiber officinale) was administered orally in the experimental group and continued daily for 10 days after surgery. Several inflammatory markers were measured to evaluate the postsurgical status of the animals in the different times. Although there was no difference in the albumin and glucose level between the experimental and control groups at the different times, a statistically significant reduction in the inflammatory markers C-reactive protein (CRP), fibrinogen, tumor necrosis factor a (TNF-α), and interleukin 6 (IL-6) was observed in the experimental group compared to the control group. These preliminary findings suggest the usefulness of ginger rhizome powder, a traditional herbal dietary supplement, in the reduction of postoperative inflammatory reactions in dogs undergoing ovariohysterectomy.

Bovine leukemia virus (BLV) is an oncogenic B-lymphocytotropic retrovirus and structurally related to the human T cell leukemia virus type ? (HTLV-?). Some haematological changes have been reported within the different stages of BLV. Altered blood enzyme profile, as well as biochemical parameters were also reported by different researchers. The aim of the present study was to biochemical evaluation of cattles serum infected with bovine leukemia virus. The experiment included ?? cows at various ages and body weight.On the basis of haematological results, the cows were divided into two groups: first group –BLV seropositive with normal lymphocyte; second group – BLV seropositive with increase lymphocyte. blood samples were collected from the jugular vein for Biochemical evaluation of cattles serum such as AST, GGT, calcium, Phosphor, BUN and Creatinin. Results indicated that The serum Phosphor concentration of persistent lymphocytosis (PL) Holstein cows (?.??±?.??) was significantly higher than that Non persistent lymphocytosis Holstein cows (?.??±?.??). Also, the The serum Calcium and aspartate aminotransferase (AST) concentration of persistent lymphocytosis (PL) Holstein cows (?.??±?.??) and (??.??±?.??) was significantly lower than that Non persistent lymphocytosis Holstein cows (?.?±?.??) and (??.??±?.??). There were no statistically significant changes in the other studied blood biochemical indices. Based on the result of present study, could be concluded that changes in some biochemical parameters in cattle infected with enzootic bovine leukosis virus in differentiation of bovine leukosis stages.

Ascites syndrome is one of the most important metabolic disorders in growing broiler chickens world-wide.

This study investigated the effect of broccoli in comparison to ascorbic acid on controlling pulmonary hypertension syndrome (PHS) in broiler chickens.

A total of 144 one-day old chicks were randomly divided into four groups. Each group included 36 chicks with three replicates of 12 birds. Experimental treatments were control, ascorbic acid (500 mg/kg dietary), and two levels of broc-coli (0.5% and 1% dietary broccoli powder). Growth performance, hematocrit or packed cell volume (PCV), heterophil to lymphocyte (H:L) ratio, right ventricle to total ventricle weight ratio (RV:TV), serum biochemical factors, lipid peroxidation, total antioxidant capacity, as well as humoral and cellular immune responses were evaluated.

Growth performance parameters improved in experimental treatments compared to control, even though it was not statistically significant. The RV:TV ratio in treatment groups was lower than control, and it was significant in ascorbic acid and broccoli 1% (p ≤0.05). H:L ratio decreased in treatment groups than control (p ≤0.05). Nitric oxide and HDL-C levels increased at both broccoli levels than control (p ≤0.05), but LDL-C and triglyceride levels decreased (p ≤0.05). Serum malondialdehyde (MDA) and total antioxidant capacity were lower and higher in treatment groups than control, respectively (p ≤0.05). There were no significant changes in other parameters.

This research showed that addition of broccoli to the diet of broiler chickens, through improving anti-oxidant parameters, increasing serum nitric oxide levels, and decreasing blood pressure, blood lipids, RV:TV ratio, and mortality, could be effective to prevent PHS.

In this study, the effects of broccoli and mulberry leaf on growth performance and intestinal villi morphology in broiler chickens were evaluated. A total of 216 one-day old broiler chickens were randomly divided into 6 groups with 3 replicates of 12 birds. Group 1 received basal diet with standard ration of broiler chickens. Group 2 was fed with a diet containing 500 mg/kg of vitamin C. Groups 3 and 4 received diets containing 0.5 % and 1 % of broccoli powder, and groups 5 and 6 received diets containing 0.05 % and 0.1 % of mulberry leaf ethanoic extract respectively. Variables related to growth performance and intestinal villi morphology were evaluated at age 35. Growth performance increased in experimental treatments in comparison to control, but did not show statistically significant difference. The results of intestinal morphology indicated that in the duodenum, all parameters were higher in experimental treatments than control (P<0.05). In the jejunum, villi height was higher in all treatments exception to mulberry leaf 0.05% and absorption surface of the groups vitamin C, broccoli 1% and mulberry leaf 0.1% was more than control (p<0.05). In the ileum, vitamin C in all parameters and mulberry leaf 0.1% had more villus width and lamina propria depth than control (P<0.05). The present study showed that the addition of broccoli powder and mulberry leaf ethanoic extract to broiler chickens diet improved the intestinal villi morphology in terms of height and absorption surface and could increase the food absorption, so relatively improve growth performance.

In order to measure some of the blood serum biochemical parameters in normal rearing conditions and determination of their relationship with body weight and carcass components and also the examination of sex effect on blood biochemical parameters in Isfahan native chicken, an experiment was conducted using 200 one-day-old native chickens. The chicks were reared in completely identical conditions for 12 weeks. At the end of week 12 and after six hours of fasting, the chicks were slaughtered, and their body weight and various carcass components were measured. The cholesterol, triglyceride, total protein, albumin, uric acid, calcium, phosphorus, malondialdehyde, high density lipoprotein and glucose concentrations were measured using commercial kits. The amount of globulin was calculated as the difference of total protein and albumin. The results showed that the highest significant positive correlation (P<0.05) was observed between cholesterol with body weight and thigh weight (0.21) and the highest significant negative correlation was observed between uric acid concentration and liver weight, and between calcium and breast weight (-0.24). The multiple regression analysis showed that cholesterol, globulin and phosphorus parameters could be used to predict body and breast weights, as well as cholesterol and globulin levels for predicting of carcass and thigh weights. In addition, there was no significant difference between two sexes in any of the measured biochemical parameters. According to the results of this experiment, blood parameters could be used to predict some carcass characteristics in Isfahan native chicken.

In this research to evaluate the effects of probiotic on the growth and some serum biochemical parameters of growing native kid’s, 24 kid’s, with 19.2± 0.7 kg body weight and 120± 10 days of age were used in a completely randomized design with four treatments and six repeats. These four groups included: 1- The control group was fed on a basal diet (without probiotic or yeast). 2- The second group received basal diet plus one g/day protexin for each kid. 3- The third group was fed on basal diet and two g/day Levocil SC2 yeast, for each kid and 4- The fourth group was fed on basal diet plus one g/day of Levocil SC2 yeast and a half g/day of protexin for each kid. After 14 days adaptation to experimental pens, the kids had free access to experimental diets among 74 days. Daily dry matter intake (DMI), and animal weight changes were recorded. Blood samples were collected from kids. According to the result, there were non-significant differences in treatments concerning, DMI daily gain and feed conversion ratio (P>0.05). Also concentration of some blood parameters such as blood urea nitrogen, total protein, globulin were not affected by probiotics (P>0.05). Glucose, albumin, triglyceride and cholesterol concentration of kid’s serum in group 2 (protexin treatment) were higher than other groups (P