فهرست مطالب afsaneh astinchap

Non-alcoholic fatty liver disease, characterized by the deposition of fat in liver cells, can cause fibrosis, cirrhosis, and liver cell damage if not controlled. The aim of this study was to determine the effects of 8 weeks endurance training on fatty liver and lipid profile indices, insulin resistance and body composition in diabetic women with NAFLD.

in this study, 30 diabetic women (age 53±7, height 158±4, and weight 75±9) with non-alcoholic fatty liver participated. Subjects were randomly divided into two groups of control (n=15) and exercise (n=15). The training group program was performed by running in each session for 30-45 minutes and 60-70% of the heart rate reserve and three sessions per week for eight weeks. Liver enzymes, lipid profile, blood sugar, insulin, insulin resistance index, Percent body fat and VO2max were evaluated before and after the training protocol. ANOVA test with repeated measures was used to determine the differences. With confidence interval of P<0.05.

Results of analysis of variance with repeated measures in lipid profile variables (TG, TC, HDL and LDL), liver enzymes (ALT and AST), insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Body mass index showed that the interactive effect of time × group was significant in these variables  (P<0.05). The results of Bonferroni post hoc test reported a significant decrease in fat profile variables in the exercise group compared to the control group except for HDL in the exercise group, which did not show a significant change and in the control group (P <0.05). Also, the comparison between groups showed that there was a significant difference between control and exercise groups in fasting blood sugar factors, ALT, AST, TG, HDL, LDL, insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Percent body fat (P<0.05).Discussion and

These results suggest that moderate intensity aerobic exercise can play an important role in the improvement of these patients by compensating for the destructive effects of type 2 diabetes and non-alcoholic fatty liver. In addition, aerobic exercise can prevent the progression of NAFLD.

 There is limited research on the effects of physical activity with moderate intensity on βklotho (BKL) and fibroblast growth factor-21 (FGF-21) proteins expression in diabetic patients with non-alcoholic fatty liver disease (NAFLD).

 This study was aimed to determine the effects of eight weeks of endurance and resistance training on BKL and FGF-21 proteins expression in diabetic women with NAFLD.

 Forty-five diabetic women (age: 51 ± 8 years, height: 158 ± 2 cm, weight: 75 ± 8 kg) with NAFLD participated. The subjects were randomly divided into three groups, including control (n = 15), endurance training (n = 15), and resistance training (n = 15). The enzyme-linked immunosorbent assay (ELISA) was used to measure BKL and FGF-21 proteins. Two-way ANOVA with repeated measures was applied to determine differences at a significant level of P < 0.05.

 Eight weeks of endurance and resistance training reduced AST, ALT, and FGF-21 (25, 26, 19% and 13, 16, 13%, respectively) and increased BKL (16% and 18, respectively). However, in the variables of HDL, insulin, AST, ALT, FGF-21, and BKL, a significant difference was observed in the control group (P < 0.05). Also, there was a significant difference between the control and training groups in BKL and FGF21 proteins expression (P < 0.05), but no significant difference was observed between the two training groups (P > 0.05).

 The results suggest that both moderate-intensity endurance and resistance training can modulate the destructive effects of type 2 diabetes and NAFLD on BKL and FGF-21 proteins expression, and there is no difference between the two training methods.

Research on the effects of endurance training on fibroblast growth factor 21 (FGF21) and βKlotho protein expression in patient with nonalcoholic fatty liver disease (NAFLD) is limited. We aimed to determine effects of eight weeks endurance training with moderate intensity on FGF21 and βKlotho protein expression in diabetic women with NAFLD.

Thirty diabetic women (age 53 ± 7, height 158 ± 4, weight 75 ± 9) with NAFLD participated in this study Subjects were randomly divided into two groups of control (n = 15) and exercise (n = 15). The training was performed by running in each session for 30-45 min with 60-70% of the heart rate reserve and three sessions per week for eight weeks. Control group did not perform any exercise program. Rockport walking test and ELISA technique were used to measure VO2max and βKlotho and FGF21 protein expression, respectively. Two-way ANOVA test with repeated measures and p < 0.05 was used to determine the significant differences.

Except for βKlotho serum level, none of the other variables of the control group showed significant difference in pre and post training. However, in the training group, weight, fat percent, body mass index, Waist to hip ratio, insulin, glucose, βKlotho and FGF21 levels were significantly changed after training (p < 0.05). A significant difference was observed between control and training groups in βKlotho and FGF21 levels (p < 0.05).

Endurance training could improve imbalance of FGF21 and βKlotho protein expression in women with type 2 diabetes and NAFLD.

Non-alcoholic fatty liver disease, characterized by the deposition of fat in liver cells, can cause fibrosis, cirrhosis, and liver cell damage if not controlled. The aim of this study was to determine the effects of 8 weeks endurance training on fatty liver and lipid profile indices, insulin resistance and body composition in diabetic women with NAFLD.

in this study, 30 diabetic women (age 53±7, height 158±4, and weight 75±9) with non-alcoholic fatty liver participated. Subjects were randomly divided into two groups of control (n=15) and exercise (n=15). The training group program was performed by running in each session for 30-45 minutes and 60-70% of the heart rate reserve and three sessions per week for eight weeks. Liver enzymes, lipid profile, blood sugar, insulin, insulin resistance index, Percent body fat and VO2max were evaluated before and after the training protocol. ANOVA test with repeated measures was used to determine the differences. With confidence interval of P<0.05.

Results of analysis of variance with repeated measures in lipid profile variables (TG, TC, HDL and LDL), liver enzymes (ALT and AST), insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Body mass index showed that the interactive effect of time × group was significant in these variables  (P<0.05). The results of Bonferroni post hoc test reported a significant decrease in fat profile variables in the exercise group compared to the control group except for HDL in the exercise group, which did not show a significant change and in the control group (P <0.05). Also, the comparison between groups showed that there was a significant difference between control and exercise groups in fasting blood sugar factors, ALT, AST, TG, HDL, LDL, insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Percent body fat (P<0.05).

These results suggest that moderate intensity aerobic exercise can play an important role in the improvement of these patients by compensating for the destructive effects of type 2 diabetes and non-alcoholic fatty liver. In addition, aerobic exercise can prevent the progression of NAFLD.