فهرست مطالب aliasghar arabi mianroodi

Human papillomavirus virus (HPV) plays an important role in some human malignancies, including head and neck squamous cell carcinoma (SCC). However, it is necessary to evaluate the role of carcinogenic agents in local settings as well. Therefore, this study aimed to evaluate the frequency of HPV genotypes in head and neck epithelial cancers. In this case-control study, 202 patients with suspected carcinoma referred to Shafa Hospital (Kerman, Iran, 2017) for pathological evaluation were enrolled. A definitive diagnosis of carcinoma was reported for 101 patients (case group) and in the other 101 subjects, carcinoma was not diagnosed. In order to determine the presence and type of HPV in tissue samples, the PCR method was used. Data analysis was performed using Fisher’s exact test, independent t-test, and logistic regression.  In total, 27 head and neck SCC samples (26.7%) were positive for HPV DNA. In addition, the virus species were HPV-11 in 15 cases (14.9%), HPV-16 and HPV-18 in 12 cases (11.9%), and HPV-6 in 10 cases (9.9%). According to the results, the presence of HPV was significantly higher in patients with SCC (P < 0.001). Moreover, smoking (P = 0.03) and opioid use (P < 0.001) were also significantly associated with SCC. The results of the present study demonstrated the presence of HPV in tissue samples of head and neck SCC patients in Kerman, Iran. Further studies are needed to investigate the preventive role of HPV vaccination in head and neck SCC.

It is well known that Staphylococcus aureus biofilm plays an important role in adenoiditis and biofilm resistance frequently results in failure of therapy. The goal of this study was to evaluate the biofilm production of S. aureus isolates obtained from adenoid specimens and assess the relationship between biofilm formation ability and ica operon genes.

A total of 112 adenoid samples were obtained from patients under 15 years old with adenoid hypertrophy. All S. aureus isolates were initially identified by standard microbiological tests and amplification of nuc by polymerase chain reaction (PCR) technique. Biofilm formation of S. aureus isolates was evaluated and icaADBC genes were detected by PCR technique.

There were 46 isolates (41%) identified as S. aureus. The ability to produce biofilm was detected among total S. aureus isolates. Molecular study of ica operon revealed that 2 (6.3%) and 19 (59.4%) isolates carried icaA and icaD, respectively. The prevalence of icaA + icaD was seen among 11 (34.4%) S. aureus isolates, while icaC and icaB were not detected.

Our findings indicated that icaABCD operon are associated with biofilm formation in S. aureus isolates, however the absence of these genes may not necessarily exclude this property.

Olfactory and gustatory dysfunctions can be considered as important symptoms to screen for the mild cases of the COVID-19 disease. However, there are limited studies on the specificity of olfactory and gustatory changes in patients with COVID-19, and it is unclear to what extent the changes may be unique to the disease. This study aimed to evaluate the duration and outcome of olfactory and gustatory disorders in patients with COVID-19.

The study population was patients with COVID-19 at Afzalipour Hospital whose disease was confirmed by nasopharyngeal polymerase chain reaction (PCR) test. 20 patients with olfactory and gustatory dysfunctions were studied. Data were collected using two forms, which were completed at the time of diagnosis and two weeks after the onset of the disease.

In 20% of the patients, olfactory and gustatory dysfunctions were among the early symptoms. In 85% of the cases, these dysfunctions were permanent during the disease. 30% of the cases had a chronic underlying disease such as sinusitis, nasal polyps, and allergy. In follow-up, 13 patients (60%) reported that their olfactory dysfunctions had completely improved.

The patients whose only symptom is the sudden olfactory or gustatory dysfunction or the dysfunctions are among their early symptoms, should be screened for COVID-19. Most of the patients will recover over the time.

Attention deficit hyperactivity disorder (ADHD) has the highest prevalence among psychiatric disorders in children. The present study investigated the effect of adenotonsillectomy on the symptoms of ADHD in a 6-month follow-up.
 
This cross-sectional study was performed on 100 patients referred for respiratory problems during sleep due to adenotonsillar hypertrophy (ATH). The patients’ parents were asked to complete the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition checklist as a standard benchmark for ADHD before, 2 weeks, and 6 months after the surgery. The data were analyzed by SPSS software (version 20) through paired t-tests and McNemar’s test.
 
The age averages of male and female children were 7.15 and 8.4 years, respectively. The frequency of ADHD in the studied population was 30%, which is much higher than the prevalence of this disorder in the normal population. In the second week after the surgery, the mean score of ADHD decreased from 4.97±2.97 (attention deficit [AD]) and 6.77±1.61 (hyperactivity disorder [HD]) before the surgery to 3.86±2.25 (AD) and 4.28±2.02 (HD) 2 weeks after the surgery (P=0.001). After a 6-month follow-up, these figures further decreased (AD=2.34±2.32; HD=1.97±2.44; P<0.001).
 
Adenotonsillectomy had a significant effect on the improvement of ADHD symptoms. There is a necessity for checking patients with ADHD for ATH, especially in case of sleep disorders, sleep apnea, snoring, or mouth breathing.

A major problem in surgical procedures is postoperative pain. The effectiveness of prescribing preoperative tizanidine in reducing postoperative pain is not clear. The aim of this study was to determine the efficacy of tizanidine as a premedication in reducing pain after septoplasty.

This double blind clinical trial study was performed in 71 patients aged from 18 to 50 years, undergoing septoplastic surgery for the first time, who were classified in ASA (American Society of Anesthesiologists) classes 1 and 2 in the Ear, Nose, and Throat (ENT) Department of Shafa Hospital, in Kerman, Iran from April 2014  to March 2015. Patients were randomly assigned into two groups using numbers from a randomization table. A dosage of 4 mg of tizanidine was administered orally to the patients two hours before the surgery (septoplasty) in the intervention group. In the control group, placebo pills which were 100 mg vitamin B1 were prescribed. The severity of pain was measured and recorded after 4 and 8 hours, and the morning after the surgery.

62 patients (87.32%) were male and 9 (12.68%) were female. The mean age of the subjects was 24.6±7.5 years. The two groups were similar in regard to age (P=0.54), but the duration of surgery was different in the two groups (P=0.038) and was longer in the group that received tizanidine. The mean of pain was different between the two groups, after 4 hours and was significantly higher in the group that received tizanidine (P=0.043). The mean of pain was not significantly different between the two groups after 8 hours (P=0.95) or one day after surgery (P=0.79).

Although some researchers have reported that taking tizanidine before some surgeries may reduce postoperative pain, in this study the administration of tizanidine before surgery was not effective in reducing pain after septoplasty.

Noise is one of the most common and harmful physical factors in the working environment and has physical and psychological effects on individuals. In this study, the audiometry results of industrial workers were modeled and the effect of noise and other factors on hearing loss was examined.                                                                                                    This was a longitudinal study based on the records of workers who had worked over 10 years in the industry and had recorded audiometries since their employment. Data was analyzed through linear mixed models.   During each year of noise exposure, hearing loss was 1.9 db at 4000 Hz; 0.059 in low frequencies and 0.62 db in high frequencies. At 8000 Hz the effect of the age at employment on hearing loss was significant (P=0.014). At low frequencies the interaction of smoking and age at employment was significantly related to hearing loss (P˂0.001).   This study showed that despite acquaintance with safety measures, workers still face hearing loss in industry and employers should put workers under more surveillance for using protective gear. Smoking might be another risk factor for hearing loss.

Hypothyroidism means the production of thyroid hormone is inadequate for normal human activity. Due to the high prevalence of hypothyroidism after radiotherapy with and without surgery and the large number of patients treated at the radiotherapy center of Shafa hospital, this study aimed to determine the incidence of hypothyroidism in patients referred to this center and to motivate identifying them.

This cross-sectional study was performed on 100 patients visiting the Radiotherapy Center of Shafa Hospital during the years 2008-2014. Data were analyzed by SPSS version 20 using t-test in the subgroups.

The mean age of the participants was 56.65 ± 11.29 and 19% were diagnosed with hypothyroidism. There was a significant relation between the stage of tumor (P = 0.014) and type of treatment (P <0.001) with hypothyroidism.

Overall, it seems that the incidence of hypothyroidism in patients receiving radiotherapy is high, especially in patients undergoing radiotherapy with surgery. Special attention should be paid to screening patients with laryngeal cancer or other cancers of the head and neck, after radiotherapy and surgery.

Recent studies have shown interleukin 4 (IL-4) and 5 lipoxygenase (5-LO) to play an important role in development of nasal polyposis. Investigation into the genetic factors associated with allergic and non-allergic nasal polyposis has been examined for more than fifteen years. Despite these efforts, the genetic factors underlying the development of nasal polyposis have yet to be clearly understood. The current study examined the relationship between C-590T promoter polymorphisms of the IL-4 gene and the presence of nasal polyps. Additionally, we examined the levels of 5-LO expression in nasal polyp tissue and its association with the IL-4 promoter gene polymorphisms. A total of 320 subjects were enrolled in the study, of which 256 were healthy controls and 64 were patients with nasal polyps. The Real-Time PCR HRM-based method was used to determine the genotypes of IL-4 C-590T. The expression of 5-LO within the 64 samples of nasal polyp tissue was determined by immunohistochemical staining to examine the association of 5-LO with the IL-4 C-590T genotype. Genetic analysis showed a significant difference in the frequencies of the IL-4 polymorphisms at C-590T in patients with nasal polyps as compared with controls (p<0.001). No significant difference was seen in the expression of 5-LO among genotypes in patients with nasal polyps (p=0.139). The results suggest that the inheritance of TT and CT genotypes at the IL-4 C-590T promoter gene is associated with nasal polyps however, there is no association between the expression of 5-LO in nasal polyp tissues and IL-4 C-590T genotypes in patients with nasal polyps

Allergic rhinitis and asthma can be related to occupation. The present study aimed to investigate the correlation between asthma or allergic rhinitis and employment in the palm tree gardens of Jahrom, Iran.
This was a cross-sectional study including 50 palm tree garden workers and a control group of 50 office employees. Data collection included demographics, as well as standard International Study of Asthma and Allergies in Childhood (ISAAC) and A New Symptom-Based Questionnaire for Predicting the Presence of Asthma (ASQ) questionnaires. Data were analyzed using SPSS22. Descriptive statistics, chi-square test, t-test, and logistics regression were used to analyze data.
The correlation between asthma and occupation was significant ( P=0.046); and asthma prevalence was higher in palm tree garden workers. However, no relationship was observed between age, duration of employment, smoking cigarettes, hookah, or opium addiction with asthma. Furthermore, in this study, no significant relation was observed between the prevalence of asthma and contact with dust, contact with pets’ skin and hair, family history of asthma, or the use of perfume and air freshener. The symptoms of allergic rhinitis (including sneezing, runny nose, and blocked nose) were significantly greater in palm tree garden workers (P=0.038). These symptoms in both workers and office employees were higher in spring.
In our study, allergic rhinitis and asthma were more common in palm tree garden workers than in the general population. According to our study, people working in this occupation should take necessary precautions.

Adenotonsillar hypertrophy is a typical cause of surgery in children. Evaluation and identification of patients as potential candidates tonsillectomy is a primary concern for otolaryngologists. This study focuses on the results of pulmonary function tests (PFTs) after tonsillectomy in children. This cross-sectional study examined 50 patients suffering from tonsillar hypertrophy in 2013. Full details and results of otolaryngology examinations were recorded. Moreover, patients were examined with respect to forced inspiratory flow at 50% of vital capacity (FIF50%), forced expiratory flow at 50% of vital capacity (FEF50%), forced expiratory volume in 1 second (FEV1)/peak expiratory flow rate (PEFR), and FEV1/forced expired volume in 0.5 seconds (FEV0.5) before and after surgery using spirometry. All data were analyzed using SPSS Software (version 19), and central descriptive measures, and data were compared by performing T-test and Chi-square tests. According to tonsil size, patients were distributed as follows: 18 patients (36%) with +1 tonsil size, 18 patients (36%) with +2 tonsil size, and seven patients (14%) with +3 tonsil size, and seven patients (14%) with +4 tonsil size. Thirty-three (66%) and 17 patients (34%) were female and male, respectively, with a mean of age of 9.7 2.97 years (range, 7–18 years). Seventy-eight percent of patients were aged 10 years or less. Moreover, 25 patients (50%), 17 patients (34%), and eight patients (16%), respectively, reported obstructive symptoms, recurrent tonsillitis, and both symptoms. In patients with +3 and +4 tonsil size, spirometric parameters indicated relief of symptoms of obstruction. Only in patients with +4 tonsil size were the changes statistically significant. Tonsillectomy can relieve obstructive symptoms in patients with tonsils larger than +3 to a great extent. Additionally, spirometry can identify patients with +3 and +4 tonsils who do not have clinical signs of an obstructive upper airway.

Neoplasms of the parotid glands are rare and constitute 3-4% of all head and neck tumors. The aim of this study was to determine the epidemiology of parotid surgeries at the ear, nose, and throat (ENT) department of Shafa Hospital, Kerman, Iran. In a cross-sectional study from March 2006 until March 2011, all patients who had had parotidectomy at Shafa Hospital (n = 47) were included. Their tumor type, pathology, age, gender, type of surgery, and early surgery complications were evaluated. The mean age of the patients was 40.1 years and 20 of them (42.6%) were male. Seven cases (14.9%) had malignant tumors and 37 (78.7%) had benign tumors. Total and subtotal parotidectomy were performed for 21.3% and 78.7% of the patients, respectively. Early complications of surgery were detected in eight cases (17.0%), i.e. four cases (8.5%) had facial paralysis, three patients (6.4%) had hematoma, and one individual (2.1%) had an infection. Malignancy was not significantly related with either age or gender. The prevalence of benign and malignant tumors and complications of surgery in this center was similar to other national and international studies. Systematic data collection and appropriate databases should be established to increase accuracy and reduce errors in similar research.

Rhinoplasty is a popular cosmetic surgical procedure. Informal statistics show that Iran has one of the highest rates of rhinoplasty in the world. However, rhinoplasty like any other surgery can have complications. In this cross-sectional study, 320 female students were selected by multistage cluster-stratified sampling from high schools in Kerman, Iran and each completed a questionnaire. More than half of the students said they would like to undergo rhinoplasty. The main reasons for wanting rhinoplasty were beauty and because it is fashionable. However, more than half of the interested students did not know about the possible postoperative complications of rhinoplasty. There was no relation between interest in having rhinoplasty and parents’ education, city of birth or economic status. Many teenagers are interested in having rhinoplasty in Iran. As the number of teenagers and young adults who choose to have cosmetic surgery increases, surgeons should consider their expectations, motivations and awareness of postoperative complications before surgery.

The diagnosis of foreign bodies in the upper aerodigestive tract is usually straightforward but sometimes it can be delayed or the location of esophageal and upper airway foreign bodies can be mistakenly interchanged. Case Report: We present two interesting cases that caused diagnostic challenges which could have led to serious complications if a greater delay in diagnosis had occurred. In order to diagnose upper aerodigestive tract foreign bodies without delay, a careful history and physical examination with proper X-rays are helpful.

Environmental fungi, molds and yeasts, can infest the nasal cavity through inhaled air. There is some evidence that they could be the main cause of Chronic Rhino-Sinusitis (CRS) but little is known about the normal fungal flora in the human nose.The objective of this study was to assess the normal fungal flora of the nasal mucus in adults in Kerman. We conducted a cross sectional study. Nasal swabs were used to sample the nasal cavity of 100 adults, 46 men and 54 women between 17 and 60 years old, currently living in Kerman, Iran. Among 100 healthy people, one or more types of fungi were detected in 31 (31%) persons; Candida in 12 persons, Aspergillus in 8 persons, Streptomyces in 8 persons, and Penicillium, Nocardia and Mucor in a few persons. In only 4 persons, more than one type of fungi was detected. There was no significant relation between age, sex, education or smoking with the presence of fungi.