فهرست مطالب alireza balizadeh karami

Chronic Kidney Disease (CKD) is a condition where the kidneys have abnormal structure or function that lasts for more than three months, can have negative health effects, and often does not show symptoms in the beginning. In that research, we tried to examine the diagnostic markers from the laboratory to find clues for a faster diagnosis of this disease.

This paper is a cross-sectional analytical study on 107 patients with CKD hospitalized in Abadan University of Medical Sciences educational hospitals from March 21, 2017, to March 19, 2020. Once the necessary permits were obtained, the laboratory information of patients was received from HIS. The data was analyzed by SPSS version 16 software. Statistical significance is considered when P-value>0.05.

Out of 107 patients with CKD in the study, 55 (51.4%) were female and 52 (48.6%) were male. The mean age of the group was 57.9±17.42 years. The means of renal diagnostic markers such as creatinine 7.42±4.55 and BUN 56.97±36.78 were higher than normal. Also, the mean coagulation markers, including PT (15.86±9.89), PTT (47.65±29.11), and INR (1.54±1.07), were higher than normal. The mean of hematological diagnostic markers, including hemoglobin and hematocrit, was lower than normal. The mean RDW-CV (16.97±4.19) and white blood cells (11.19±9.01) were higher than normal.

This study showed that renal markers (creatinine and BUN) and coagulation factors (PT, PTT, and INR) were higher than normal. In this study, it was observed that people with CKD are prone to anemia because a decrease in the mean hemoglobin and hematocrit and an increase in RDW-CV were observed.

Diabetes mellitus is a metabolic disease characterized by hyperglycemia that results from inadequacies in secreting insulin and/or the action of insulin. Increased exposure to particulate matter at high concentrations is associated with increased mortality in heart diseases. This study aimed to evaluate the effects of insulin and crocin on cardiac electrophysiological parameters, blood pressure, and oxidative stress in alloxan-induced diabetic rats exposed to the total suspended particulate (TSP). 

Adult male Wistar rats (n=60) with bodyweight between 200 and 250 g were divided into 10 experimental groups (6 animals per group): control, crocin, diabetic, TSP (5 mg/kg TSP, intratracheal instillation), diabetic-crocin, diabetic-insulin, diabetic-TSP, crocin-TSP, diabetic-TSP-insulin, and diabetic-TSP-crocin. The effects of chronotropic (heart rate), inotropic (QRS voltage), and dromotropic (P-R intervals and QTc intervals) were evaluated with standard bipolar limb lead II. Systolic and diastolic blood pressure measurements were recorded with the tail cuff. Antioxidant and lactate dehydrogenase enzymes were also measured. 

The diabetic groups and groups exposed to TSP experienced a deleterious effect on cardiac electrophysiological parameters and blood pressure, with a significant decrease in the activity of antioxidant enzymes. These changes were improved with crocin and insulin. 

In this work, the protective role of crocin and insulin alone was observed in diabetic groups and groups exposed to TSP by improving the electrophysiological parameters of the heart, blood pressure, and oxidative stress. 

 In recent years the prevalence of cosmetic genital surgery in women has increased. This qualitative study has attempted to explore the rationale behind the decision of undergoing aesthetic genital surgeries in a sample of seven married women who had undergone such surgeries in Iran (Tehran).

 Seven in-depth semi-structured narrative interviews were conducted, and the results were analyzed via thematic analysis techniques.

 Three main themes emerged, namely, 'individual problems', 'Couple relationships', and 'Physician-Patient Relationships'. Six sub-themes that were commonly repeated were mental health issues, inadequate sexuality education, imbalanced couple dynamics, communication difficulties, simultaneous surgical intervention in the peri-genital region, and imbalanced power relations.

 It seems that an interplay of different personal and interpersonal issues, facilitates women's decision-making process and propels women in choosing genital aesthetic surgeries. Thus, women are advised to consult with a psychosexual therapist, a clinical psychologist, or a psychiatrist before making any decision about undergoing cosmetic surgery.

MicroRNA expression signature and reactive oxygen species (ROS) production have been associated with the development of cardiovascular diseases (CVDs). This study aimed to evaluate oxidative stress, inflammation, apoptosis, and the expression of miRNA-208a and miRNA-1 in cardiovascular patients.

The study population included four types of patients (acute coronary syndromes (ACS), myocardial infarction (MI), arrhythmia, and heart failure (HF)), with 10 people in each group, as well as a control group. Quantitative real-time PCR was performed to measure mir-208 and miR-1 expression, the mRNAs of inflammatory mediators (TNFα, iNOS/eNOS), and apoptotic factors (Bax and Bcl2). XOX, MDA, and antioxidant enzymes (CAT, SOD, and GPx) were measured by ZellBio GmbH kits by an ELISA Reader.

The results showed significant decreases in the activity of antioxidant enzymes (CAT, SOD, and Gpx) and a significant increase in the activity of the MDA and XOX in cardiovascular patients. Significant increases in IL-10, iNos, iNOS / eNOS, and TNF-α in cardiovascular patients were also observed. Also, a significant increase in the expression of miR-208 (HF> arrhythmia> ACS> MI) and a significant decrease in the expression of miR-1 (ACS> arrhythmia> HF> MI) were found in all four groups in cardiovascular patients.

The results showed increases in oxidative stress, inflammation, apoptotic factors, and in the expression of miR-208a in a variety of cardiovascular patients (ACS, MI, arrhythmia, and HF). It is suggested that future studies determine the relationships that miR-1, miR-208, and oxidative stress indices have with inflammation and apoptosis.

The effect of total suspended particulate matter (TSP) was investigated on the expression of inflammatory and apoptotic factors in diabetic rats, and the effect of crocin and insulin was examined on these factors. 

Fifty-four adult male wistar rats were divided into nine experimental groups: control group, crocin group (received crocin, 50 mg/kg), diabetic group (received a single dose of alloxan at 120 mg/kg, IP), TSP group (5 mg/kg TSP instilled intratracheally), diabetic-crocin group (received crocin at 50 mg/kg after the induction of diabetes by alloxan (120 mg/kg)), diabetic-insulin group (received regular insulin (5 U/kg), crocin-TSP group (received crocin at 50 mg/kg, IP, and then 5 mg/kg TSP was instilled intratracheally), diabetic-TSP-insulin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose (5 U/kg) of regular insulin), and diabetic-TSP-crocin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose of crocin (50 mg/kg, IP)). Quantitative real-time PCR was performed to measure the expression of the mRNAs of apoptotic (Bax and Bcl2) and inflammatory mediators (TNFα, COX2, iNOS/eNOS) in Wistar rats.

In diabetic and TSP groups the inflammatory factors and BAX/Bcl2 ratio significantly increased compared to the control group. In diabetic-TSP-insulin and diabetic-TSP-crocin, a significant decrease was observed in the rate of inflammatory factors and BAX/Bcl2 ratio.

The results suggested that diabetes and exposure to TSP increase the rate of apoptosis and inflammation, and also demonstrated the anti-apoptotic and anti-inflammation role of insulin and crocin.

Liver diseases have a lot of pain and suffering for the patients and also cost a lot to cure. In this study, we tried to collect comprehensive and applied information about the incidence of these diseases in Abadan and Khorramshahr cities and provide it to the ministry of health and public opinion.

Referring to the medical records department of Ayatollah Taleghani and Shahid Beheshti Hospitals in Abadan city and Valiasr Hospital in Khorramshahr city, information about patients with liver diseases from 2012 to 2017 were collected from the Hospital Information System (HIS) of the hospitals. The findings were analyzed using SPSS software.

In our study 62.1% of the patients were male and 37.9% were female. The highest frequency of liver diseases was in the age group of 35-44 years. The lowest incidence was in the age group of less than 1 year and 1-4 years. The most common causes were cirrhosis (319 cases), inflammatory liver disease (121 cases), other specified liver diseases (133 cases), liver failure (71 cases), secondary malignant neoplasm (52 cases), hepatitis C (53 cases), hepatitis B (25 cases), and Fatty liver (20 cases).

According to the results of this study, it was observed that the prevalence of liver diseases, especially liver cirrhosis, was the highest. As a result, people need to modify their lifestyle and consider weight loss, low-fat diet, and increased physical activity to reduce their body mass index.