alireza said

The purpose of the present study was to investigate the effect of SNL on the expression of TRAF6 muRF1 genes in the Soleus muscle of Wistar rats after HIT traning. For this purpose, 24 male rats were divided into 2 groups of control (C) (n=12) and training (HIT) (n=12). After one-week familiarization, training group participate in four HIT training. Then, they were randomly assigned to HIT (n=6) and HIT-SNL (n=6) groups. At the same time, the control group was divided into two groups: control (C) (n=6) and spinal cord nerve (C-SNL) (n=6). 4 weeks after the SNL, wistar rats were sacrificed and soleuse muscle exetracted.Then Gene expressions of MuRF1 and TRAF6 measured Real time PCR technique. The results showed that inactivity by SNL has a significant effect on the expression of TRAF6 and MuRF1 genes (P=0.0001 and P=0.0001, respectively). Also, performed before SNL reduced the expression of TRAF6 and MuRF1 (P=0.003 and P=0.0001 respectively). In addition, the findings indicated that SNL had a significant effect on the weight of Soleus muscle mass/ tibia length (P=0.01). On the other hand, HIT training before SNL significantly increased weight of Soleus muscle mass/ tibia length (P = 0.03). Therefore, the decrease in activity by SNL is associated with increased in expression of TRAF6 and MuRF1 genes, which may also be involved in muscle mass changes. Regarding the fact that performing HIT reduces the expression of these genes in soleus muscle, these training can be used to maintain obtimal muscle mass before physical activity.

Several studies have compared surgical and conservative methods for the treatment of fingertip injuries. However, there are few studies on the effect of phenytoin dressing and its efficiency in treating the fingertips compared to other common treatments. The aim of this study was to compare phenytoin dressing, surgical treatment with VY flap technique and conservative treatment with Vaseline in patients afflicted with fingertip injuries. This prospective cohort research was conducted on all patients referred to the Emergency Department of Gorgan Hospital during 2016-17 who suffered from fingertip injuries. The eligible patients were selected for further intervention and follow up and were divided into three groups including phenytoin dressing, surgical treatment with VY flap technique and Vaseline conservative treatment. The collected Data was analyzed using Chi-squared test and independent sample t-test and the significance level was considered below 0.05. After 12 months, subjective, objective, and cosmetic complaints were evaluated based on the Allen Impairment Scale. According to the statistical evaluations, no significant difference was found between the three groups in subjective, objective, and cosmetic complaints after one year (P<0.05). The results of this study for the first time showed that phenytoin dressing has a similar effect to Vaseline dressing for the treatment of fingertip injuries and is not superior to it. Furthermore, the findings of this study, in agreement with previous studies, showed that clinical results are similar to conservative and surgical treatments and are not superior to each other.