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A reasonable number of male infertility cases are related to genetic factors. Considering the high prevalence of chromosomal abnormalities related to male infertility, this study investigated the association of the chromosomal aberrations and chromosome variants with hormonal levels, a positive family history, parental consanguinity and a specific lifestyle. We also aimed to find a predictive factor to estimate the risk of the presence of an abnormal karyotype in the azoospermic and especially sever oligozoospermic men.
A total of 230 infertile men and 50 healthy controls enrolled in the study for cytogenetic evaluation. Data on patients" characteristics were gathered, accurately.
Among aforementioned factors, only luteinizing hormone (LH) >12 IU/l raised the chance of detecting a chromosomal abnormality (P Conclusiond: This study suggests a positive family history of infertility, parental consanguineous marriages and high levels of FSH as strong determinants or risk factors for male infertility. Nonetheless, the presence of these patient characteristics did not prove to have a direct correlation with chromosomal abnormalities in male infertility. Among the various possible risk factors studied, an elevated gonadotropin level provides a better risk assessment for the incidence of chromosomal abnormality in infertile men.

Numerical and structural chromosomal abnormalities are known to be associated with predisposition to hematologic malignancies development and even different response to treatment. Both diagnostic and prognostic values of cytogenetic analysis of chromosome rearrangements are helpful for better therapeutic decision in management of hematologic malignancies. On the other hand, the study of chromosomal rearrangement in patients with leukemia has led to the identification of the relationship between chromosomal abnormalities and the prognosis of the disease. This study aimed at determining the incidence of structural and numerical chromosomal abnormalities in patients with hematologic malignancies and their correlation with prognostic factors.
Material & Cytogenetic analysis was performed on 59 bone marrow samples from patients who were referred to genetics laboratory of Alzahra University-Hospital of Isfahan Medical University.
Karyotype analysis of these 59 patients showed chromosomal abnormalities in 16 (27.1%) patients and the remaining 43 (72.8%) patients had normal karyotype.
The results suggest that conventional karyotype analysis can be used as an effective method for diagnosis and prognosis in patients with hematological malignancies.