فهرست مطالب armita mahdavi

The vascular endothelial growth factor (VEGF), as an angiogenic cytokine, binds endothelial cell receptors and stimulates angiogenesis and collateral formation. We evaluated the association between VEGF plasma levels and the gene polymorphism rs699947 and the formation of coronary collaterals in patients with coronary artery disease. A total of 195 patients with ≥70% narrowing in at least 1 coronary vessel (according to coronary angiography) were included in the study. The presence of the rs699947 polymorphism within the promoter of the VEGF gene was investigated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The plasma VEGF concentration was quantified via the ELISA method. The Rentrop method was used to grade the extent of collateral development. There was no significant difference in VEGF levels between the groups with good and poor collaterals. The frequency of the A allele of rs699947 was found to be higher in the patients with good collaterals than in those with poor collaterals (P=0.014). The odds ratio of good collaterals for AA was 2.67 (P=0.025) when compared with the CC genotype. Further, our additive model revealed an association between the rs699947 polymorphism and collateral formation (OR: 1.96, 95% CI: 1.05–3.65, P=0.033). The rs699947 polymorphism might be a novel genetic factor affecting collateral development in Iranian patients with coronary artery disease.

Nutritional habits and its determinants, especially in children and adolescents have recently turned into the one of the major concerns of health researches. We examine the diet contribution inequality in according to socio-demographic factors, age, gender, physical activity and body image to alleviate this gap in Iranian children and adolescents. Study sample was comprised of 14,880 students aged 6-18 years who selected from urban and rural districts of 30 provinces of Iran via stratified multi-stage sampling method. A short food frequency questionnaire was used for estimating the food group consumption. The Blinder-Oaxaca method was applied to investigate the inequality in the prevalence of healthy and junk foods consumption between the first and fifth socio-economic status (SES) quintiles. The frequency of healthy and junk foods consumption showed considerable differences between the SES quintiles. The highest differences were found in the frequency of fresh fruit (25.38%), vegetable (12.92%), and milk (10.74%) consumption, respectively. The daily consumption of vegetables, and fresh and dried fruits increased linearly by increasing the SES quintiles. The highest absolute difference was seen in the frequency of fresh fruit consumption between the bottom and top of the socioeconomic groups (SII value=-32%). The estimated SII was statistically significant for the consumption of all healthy and junk foods except for fast foods and milk consumption. The estimated C index for consumption of healthy and junk foods was positive and negative, respectively. This study provides the considerable information on the consumption of healthy and junk foods and its determinants among Iranian children and adolescents for better programming, developing health policies, and future complementary analyses.

Risk taking behaviors have several negative consequences. This study aimed to identify the subgroups of students based on risk-taking behaviors and to assess the role of demographic characteristics, depression, anxiety, socioeconomic status (SES), physical inactivity and screen time on membership of specific subgroup. Study design: Cross-sectional study. This nationwide survey was conducted in 2011-2012 among 14880 students, aged 6-18 yr, selected by multistage, cluster-sampling method from 30 provinces of Iran. The students completed two sets of anonymous and validated questionnaires, obtained from the World Health Organization-Global School Health Survey questionnaires. Latent class analysis was performed to achieve the study objectives. Overall, 13486 children and adolescents participated were enrolled (response rate 90.6%). They consisted of 50.8% boys, with a mean age of 12.47 ±3.36 year. The prevalence of physical fight, bullying, victimization, active smoking, passive hookah and passive cigarette smoking was 39.7%, 17.4%, 27.2%, 5.9%, 21.1 and 33.8%, respectively. Five latent classes were identified: (a) low risk (46.7%), (b) passive smoker (25.2%), (c violence and aggression taker with passive smoking (13.5%), (d) violence and aggression taker without passive smoking (10.8%) and (e) high risk (3.8%). Higher age (OR=1.41), being male (OR=5.21), depression (OR=4.58), anxiety (OR=3.38) and screen time (OR=3.11) were associated with high-risk class. The prevalence of some risk-taking behaviors among Iranian students is high. Our findings emphasize the importance of planning and evaluating preventive interventions by considering different high-risk behaviors simultaneously.

 In this study we evaluate the impact of the different aspects of Gold Nano-Particles (GNPs) on the target absorptive Dose Enhancement Factor (DEF) during external targeted radiotherapy with photon beams ranging from kilovolt to megavolt energies using Monte Carlo simulation. We have simulated the interaction of photon beams with various energies of radiation using water solution containing GNPs to be located in a tumor region and used MCNP5 code for Initially, the water phantom in which a tumor dimensions of 1 × 1 × 1 cm3 was defined as the target, contained simulated GNPs. Then, themacroscopic DEF of GNPs of different sizes, including 15, 50, and 100 nm, had been calculated at the target area with a fixed concentration of 7 mg/g during external beam radiotherapy with single-energy photon beams ranging from keV to MeV. The tumor DEFs in the presence of GNPs were obtained 1.69-2.66and 1.08-1.10 for keV and MeV beams, respectively. The highest DEF was achieved by photon energy of 50 keV. By increasing the size of the GNPs, the tumor dose factor raised too. The factors calculated for enhancing the target dose of GNPs were in good agreements with previous studies based on keV photon energies. For MeV photon energies, after a reduction in the boundary between the two areas of water and the solution containing GNPs, the dose factor was enhanced to its maximum value for 2 and 6 MeV photon beams at the depths of 2.6 and 5.6 cm, respectively.

Complete revascularization is not possible in up to 37% of patients with coronary artery disease (CAD). Therapeutic angiogenesis may be considered as an option in the management of these patients. The aim of the present study was to evaluate the effectiveness and safety of therapeutic angiogenesis using basic fibroblast growth factor in patients with CAD.
In this double-blind, placebo-controlled study, eighteen patients with a severe diffuse atherosclerotic disease along the left anterior descending (LAD) artery who were a CABG candidate with at least one graftable coronary artery and the presence of ischemia and viable areas along the LAD were enrolled. The patients were randomized into two groups to either undergo CABG and simultaneous FGF-2 therapy (bFGF group) or CABG without FGF-2 therapy (control group). During the CABG procedure in bFGF group, FGF-2/alginate-heparin-sepharose microcapsules, each contains 100 mcg FGF-2, were implanted in the subepicardial layer of the diffusely defective LAD territory via 2-3 mm stab incisions. Seven patients in each group were followed up for a period of 24 months.
Findings: The result of left ventricular evaluation with echocardiography and perfusion scans showed significant improvement in FGF-2-receiving group with no significant change in controls, 3 and 6 months after the intervention. NYHA class was significantly lower in the intervention group (1.43±0.535 vs. 2.57±.535, P = 0.002), In addition, intervention group remained free of angina 24 months after the intervention while three patients in the control group were hospitalized due to the acute chest pain.
Our study revealed that FGF-2 can improve the outcomes of patients with CAD undergoing CABG, without serious adverse effects. Considering other advantages associated with protein therapy our finding may help open novel avenues to safe and cost-effective therapy of the target patients.

Widespread use of fluoroquinolones has resulted in an increasing incidence of resistance to these agents. Therefore antibiotic resistance surveillance has a great importance. This study was carried out to evaluate the antibiotic resistant pattern of Escherichia coli isolates against fluoroquinolones from ICU and out- patient clinic admitted patients with urinary tract infection in Imam Hospital of Tabriz. Urine samples were taken and E. coli were isolated by conventional laboratory methods. The isolated strains were testes by Disk Agar Diffusion (DAD) method and broth macro-dilution method (MIC) according to the CLSI guidelines. A total of hundred E. coli were isolated from urine samples. According to the results of DAD method 57 (57%) were resistant to nalidixic acid, 34 (34%) to norfoloxacin, 33 (33%) to ciprofloxacin and 30 (30%) to ofloxacin. Also 2 (2%) of isolates revealed intermediate resistance to ofloxacin. By broth macro-dilution 41% were resistant to ciprofloxacin (MIC ≥ 4µg/ml), while 6 isolates had intermediate resistance pattern (MIC=2 µg/ml) and 53 isolates were sensitive (MIC≤ 1 µg/ml) to ciprofloxacin. Our results revealed a high level of resistance against fluoroquinolones. It would be because of unjustified antibiotic usage. To overcome this problem inadvertent prescription should be limited and antibiotics should be administered based of microorganism sensitivity patterns.