فهرست مطالب babisan askari

Aging process is associated with disruption in mitochondria and liver. The aim of this study was to was to evaluate the effect of continuous aerobic exercise with citrus aurantium L. on the expression of HM and MOTS-C genes in the mitochondria of the liver tissue of elderly rats. To conduct the present experimental research, 32 elderly female rats over 14 months of age and average weight of 270 to 320 grams were divided into 4 groups of 8 including 1- Control (CN), 2- Consumption of citrus aurantium L. (CA), 3- Training (T), 4- Training and consumption of citrus aurantium L. (T+CA). During eight weeks, groups 3 and 4 ran three sessions a week with an intensity of 65-75% of the maximum running speed on the treadmill. Also, groups 2 and 4 received 300 mg/kg of CA extract intraperitoneally. 48 hours after the research protocol, gene expression levels in liver tissue were measured by real-time PCR method. Expression of HM and MOTS-C genes in CA (p=0.032 and p=0.042), T (p=0.039 and p=0.048) and T+CA (p=0.0001 and p=0.001) groups compared to CN group had a significant increase. Eight weeks of T and CA alone improved the expression of genes involved in Liver cellular senescence markers of elderly rats. Also, the simultaneous effect of exercise and CA on HM was greater than the effect of each one alone.

Infertility is actually a lack of fertility in couples that has not conceived despite a year or more of trying to reproduce. The present study was performed with aim to investigate the effect of 8 weeks of swimming training, cell therapy and vitamin E consumption on testosterone and Lc31 and P62 genes in the testicular tissue of azoospermia model rats.

In this experimental study, forty 6- to 8-week-old rats were randomly selected, and then the azoospermia model was induced with the busulfan at a dose of 40 mg. After one month, the rats were divided into 8 groups: 1) control, 2) patient, 3) sham, 4) patient + exercise, 5) patient + supplement, 6) patient + cell, 7) patient + supplement + exercise, and 8) patient + cell + exercise. Stem cells were transplanted in the vas deferens at the rate of one million cells for each mouse, they received an oral solution of vitamin E at the rate of 100 mg/kg by gavage, also the training groups performed swimming training continuously with a constant intensity of 60% of the maximum heart rate for 8 weeks, 30 minutes a day, 5 day of the week. Testosterone levels were measured by ELISA and the expression of P62 and LC31 genes in testicular tissue was measured by Real Time PCR technique. Data were analyzed using SPSS statistical software (version 26). P<0.05 was considered statistically significant.

Induction of azoospermia significantly decreased testosterone levels and the expression of Lc31 and P62 genes in testicular tissue compared to the control group (P≤0.05), but showed a significant increase in the supplement, cell, exercise, exercise+supplement and exercise+cell groups compared to the patient and sham groups (P≤0.05).

In the present study, the synergism of swimming exercise with vitamin E and mesenchymal stem cells derived from bone marrow in improving the autophagy flux in experimental rats with azoospermia was observed, which may be effective in increasing testosterone or even fertility.

Obesity is considered as a global disease. The purpose of this study was to evaluate the effect of aerobic exercise with royal jelly on the expression of BCL-2, Bax and the ratio of BCL2/Bax in the pancreatic tissue of obese rats. In this research, 40 5-week-old male Wistar rats were randomly divided into two groups of normal diet (ND) and high-fat diet (HFD). Rats in the ND group were fed a standard diet (23% protein, 65% carbohydrates, and 12% fat) and the HFD group were fed a high-fat diet (17% protein, 43% carbohydrates, and 40% fat) for eight weeks. Then, the rats were divided into 5 groups: normal diet, high-fat diet, high-fat-exercise (HFDT), high-fat-supplemented (HFDRj) and high-fat-exercise-supplemented (HFDTRj) groups. The training group performed incremental aerobic training for 8 weeks and 5 days per week. Also, the supplement groups were daily given 100 mg of royal jelly mixed in distilled water. The results showed that induction of obesity through the consumption of high-fat foods increases BCL-2 gene expression and significantly decreases BAX gene expression in the high-fat group compared to the control group. Also, endurance exercises and gel supplementation decreased BCL-2 gene expression and increased BAX gene expression in the experimental groups compared to the high-fat group and these changes were more noticeable in the combined group. It is possible that aerobic training along with the use of royal jelly can be an effective strategy in improving the condition of obesity through the process of apoptosis.

Mitochondrial collapse caused by oxidative stress is one of the important factors of insulin resistance. The purpose of this study is to investigate the effect of aerobic exercise and berberine chloride on the indices of mitochondrial regeneration and biogenesis of visceral adipose tissue in streptozotocin-diabetic rats.

32 male Wistar rats were randomly divided into four groups (n=8): diabetes (DM), diabetes-berberine (BDM), diabetes-aerobic exercise (TDM), diabetes-aerobic exercise-berberine (TBDM). Diabetes was induced by STZ injection in male rats. Berberine chloride (30 mg/kg/day) was administered orally by gavage once a day. The exercise groups performed an incremental aerobic exercise program (10-18 m/min, 10-40 min/day, and five days/week) on a treadmill for six weeks. Gene expression levels of SIRT1 and AMPK factors in visceral adipose tissue were measured using Real time-PCR method. Data analysis was conducted using one-way analysis of variance and if significant, Tukey's post hoc test was used at a significance level of p<0.05.

Data analysis showed that there is a significant difference in the expression of SIRT1 (p<0.05) and AMPK (p<0.05) genes among the groups. Furthermore, the results showed that the expression of SIRT1 gene in the diabetes-exercise group (p<0.05) and diabetes-exercise-berberine chloride (p<0.05) had a significant increase compared to the diabetes group. Berberine chloride alone could not significantly increase SIRT1 gene expression compared to the diabetic group (p>0.05). Also, the expression of AMPK gene in diabetes-exercise (p<0.05), diabetes-berberine chloride (p<0.05) and diabetes-exercise-berberine chloride (p<0.05) groups had a significant increase compared to the diabetes group.

Based on the above findings, it is possible that the simultaneous effect of exercise and berberine chloride could inhibit oxidative stress and inflammation caused by diabetes through the AMPK-SIRT1-PPARγ pathway.

This study investigated the impact of a 3-week detraining period, followed by 10 weeks of aerobic training, on the serum levels of osteocalcin and alkaline phosphatase (ALP) in asthmatic males.

Thirty adult males with asthma were randomly divided into experimental and control groups. The experimental group engaged in a 10-week aerobic training program, which included running sessions 3 times per week for 30-60 minutes each, maintaining a target heart rate range of 55%-75% of their maximum heart rate (HRmax). In contrast, the control subjects did not participate in any exercise activities during the study period. Fasting blood samples were obtained at baseline, after aerobic training, and after detraining to measure the levels of osteocalcin and ALP in both groups.

The 10-week aerobic training program led to a significant increase in levels of osteocalcin and ALP in the experimental group, but following the detraining period, these variables returned to their pre-training levels.

The effectiveness of continuous aerobic training on bone formation markers in asthmatic patients will disappear after a relatively short period of detraining. This evidence emphasizes the lack of stopping aerobic exercise in the presence of inhaled corticosteroids with the aim of improving bone metabolism in asthmatic patients.

Sedentary life and vitamin D deficiency are considered related factors to increased inflammation and oxidative stress in obese conditions. Being overweight and obese is determined by increased adipose tissue due to hypertrophy and hyperplasia of fat cells (1). Previous research has shown that overweight and obesity are associated with vitamin D deficiency (3). Vitamin D deficiency is one of the most important and common health problems associated with several diseases such as kidney disease, diabetes, cardiomyopathy and Alzheimer's disease. Vitamin D plays an important role in regulating several cellular pathways for the synthesis of antioxidants (4).The best biomarker to determine the status of vitamin D is the concentration of 25-hydroxyvitamin D. Serum levels below 20 ng /ml are defined as vitamin D deficiency (3).Large adipocytes with complete local oxygen consumption induce hypoxia, which may lead to cellular inflammation and secretion of inflammatory cytokines by activating oxidative stress pathways (4). Oxidative stress, in turn, plays a causal role in obesity (6). A strong association between oxidative stress and vitamin D deficiency has been reported (8).Vitamin D has anti-inflammatory effects and affects inflammatory processes and immune cells through different pathways, including regulating the production of anti-inflammatory cytokines (12).Interleukin 10(IL-10) is a potent anti-inflammatory cytokine that is synthesized in several organs (13). It has been observed in experimental studies that with obesity, serum IL-10 levels decreased in mice on a high-fat diet, and this reduction played a very important role in obesity-induced inflammation in other organs (15, 16). Exercise is recommended as an important non-pharmacological treatment for the prevention or treatment of obesity and its metabolic and somatic cellular complications (19). Systematic studies and available meta-analyzes have shown that high-intensity interval training (HIIT) has more significant effects on reducing abdominal and visceral fat and improving cardiorespiratory fitness in overweight and obese adults than moderate-intensity continuous exercise (21, 22). Today, lack of time is one of the main reasons for non-participation of people in regular sports activities (23). Due to the association of obesity and overweight with inflammatory factors and oxidative stress, it is necessary to conduct further studies focusing on the effect of low-risk and cheaper interventions such as HIIT and/or vitamin D consumption in the prevention or treatment of oxidative-inflammatory complications. Therefore, the present study investigated the HIIT with vitamin D intake on IL-10 and lipid peroxidation levels in overweight women with IL-10 deficiency.

This single-blind clinical trial was conducted on 52 overweight women with vitamin D deficiency and ages ranging 23-29 years old. After selecting the subjects by the available sampling method, they were randomly divided into control, interval, vitamin D and combination groups. The HIIT was performed with the 12x1-min running bouts at 80-90% maximum heart rate (HRmax) interspersed with 1-min active recovery at 50% HRmax in between bouts for 8 weeks. Vitamin D and combination groups took vitamin D once a week with food for 8 weeks (30).The vitamin D and combination groups received 50,000 IU of vitamin D per week (29). Levels of 25-hydroxyvitamin D less than 20 ng /ml were considered as vitamin D deficiency. Blood samples were collected in the pre- and post-test stages, followed by 12 hours of fasting and serum was frozen at -80 ° C. The serum was then frozen at -80 ° C and used to measure the research variables. Then, serum levels of variables were determined using a special commercial kit and laboratory methods. Malondialdehyde (MDA) levels were measured as an indicator of lipid peroxidation. One-way analysis of variance test with repeated measures and Bonferroni post hoc was also used to compare intergroup differences. In addition, the rate of change of variables was tested through Kruskal-Wallis and U Mann-Whitney tests. The significance level was considered P<0.05 and all statistical analysis was performed using SPSS software version 22.

The results of one-way analysis of variance test with repeated measures showed that there is a significant difference between IL-10 and MDA levels of inactive women during the two stages before and after eight weeks, regardless of the group factor. Also, the effect of group (regardless of time factor) and the interactive effect of time×group on the levels of these variables are significant (P<0.05). The MDA levels in interval, vitamin D and combination groups decreased significantly and IL-10 levels increased significantly after 8 weeks(P<0.001). But the combined intervention had a stronger effect on the change of MDA and IL-10 levels compared to the other two interventions (P<0.001). In addition, the effect of HIIT on decreasing MDA levels was greater than vitamin D intake (P= 0.018), and no significant difference was found between the amount of IL-10 changes in these two groups (P=0.184).

Both vitamin D deficiency (9) and obesity (33) cause overproduction of ROS, increasing oxidative stress. Reactive oxygen species (ROS) interacts with unsaturated lipids within the cell membrane and causes lipid peroxidation, which in turn significantly increases MDA levels, leading to the inactivation of many proteins and cellular receptors, causing cell membrane damage (34). Vitamin D can exert its strong anti-inflammatory activity by inhibiting the expression and activation of the pro-inflammatory transcription factor nuclear factor kappa B (NF-kB), which has optimal effects on oxidative stress (32). Regular exercise can greatly improve the efficiency of enzymatic and non-enzymatic antioxidant defense systems and enhance the body's ability to eliminate peroxidants. Exercise can inhibit NF-κB activation in human T cells by reducing ROS-producing factors, such as tumor necrosis factor-α (40). Exercise can also reduce oxidative stress by increasing the bioavailability of nitric oxide (42). However, the effect of HIIT on reducing MDA and consequent oxidative stress has been more effective than vitamin D supplementation, which may be related to the synergistic effects of these two interventions in the oxidation-antioxidant balance shift towards the superiority of antioxidant defense. It seems that HIIT and vitamin D intake can be exert their protective effects in overweight individuals with vitamin D deficiency by a decrease in the MDA and increasing the anti-inflammatory index of IL-10. Although these effects developed with combined intervention, but HIIT was associated with a greater reduction in MDA than vitamin D intervention.

Obesity and vitamin D (VD) deficiency is associated with poor sleep quality (SQ), and lifestyle changes can effectively improve SQ. The aim of this study was to investigate the effect of high- intensity interval running training (HIIRT) with VD intake on the brain-derived neurotrophic factor (BDNF) and SQ in young women with VD deficiency.

This clinical trial study was conducted on 52 women with an average age of 25.98±1.95 years, body mass index of 27.54±1.13 kg/m2 and low VD status. After being selected by the available sampling method, the subjects were randomly divided into control, running training, VD and combined groups. HIIT performed in 12x1-min running bouts at 80-90% HRmax interspersed with one minute of active recovery. VD was consumed weekly with a dose of 50,000 units. SQ was measured using the Pittsburgh Sleep Questionnaire. Data were analyzed using one-way ANOVA with repeated measures, one-way ANOVA, Kruskal-Wallis and paired t- test (p<0.05).

After 8 weeks, the levels of BDNF in the experimental groups increased and the SQ score decreased significantly (p<0.05). But the combined intervention had more effect on the change of SQ scales (p<0.05) and BDNF (p<0.001) compared to the other two interventions (p<0.05). In addition, no significant difference was observed between the changes in the SQ score of the running training and VD groups (p<0.05).

Lifestyle changes such as HIIT, VD intake, and combined intervention can lead to improvement of SQ through the up-regulation of BDNF in women with overweight and VD deficiency. Also combined intervention may have more potent effects on improving these variables.

One of the important goals of therapeutic interventions is to control obesity and vitamin D deficiency, which are associated with the occurrence of cardiovascular disease, metabolic disorders and increased homocysteine. In this study, the effect of high-intensity interval resistance training (HIIRT) and vitamin D on homocysteine and total antioxidant capacity (TAC) ​​levels in overweight women with vitamin D deficiency was investigated.

In this clinical trial study, overweight women with vitamin D deficiency were investigated. The subjects were randomly divided into four groups of 13 (control, exercise, vitamin D and exercise+vitamin D). The exercise groups performed HIIRT with an intensity of 80% of one maximum repetition, and the vitamin D groups consumed vitamin D once a week. The collected data were analyzed using one-way analysis of variance and paired t-tests.

After 8 weeks of research interventions, homocysteine level decreased and TAC significantly increased in the experimental groups (P<0.001). In addition, combined intervention was associated with more changes in homocysteine and TAC levels compared to HIIRT and vitamin D intervention (P<0.001), but HIIRT and vitamin D had a similar effect on the changes of these variables (P>0.05).

It seems that part of the optimal effects of HIIRT and vitamin D consumption in the health development of overweight women with vitamin D deficiency can be induced by increasing TAC and decreasing homocysteine.

Growing evidence, shows that vitamin D deficiency and weight gain are associated with impaired physical and mental well-being. The aim of this study was to investigate the effect of Pilates training and vitamin D supplementation on quality of life and mental health of overweight men.

This study was a randomized clinical trial performed by pre-test and post-test design. Initially, 50 overweight men were selected by convenience sampling method and then randomly divided into 4 groups including control, exercise, vitamin D and combined groups. The exercise and combined groups performed 8 weeks of Pilates training with the intensity of 50-75% of reserve heart rate, 3sessions/week. The vitamin D and combined groups received 50,000 IU vitamin D/week. Research tools were included the quality of life (SF-36) and general health (GHQ) questionnaires. The data were analyzed by paired t test, one way ANOVA and Kruskal Wallis tests (p˂0.05).

 Ethical Considerations:

 This study with research ethics code IR.IAU.BABOL.REC.1398.088 has been approved by research ethics committee at Islamic Azad University, Babol Branch, Iran

Vitamin D status in subjects was lower than normal (less than 30 ng/ml). Eight weeks of Pilates training, vitamin D intake and the combined intervention were associated with a significant improve in quality of life )10.57%, 9.26% and 15.75%, respectively (and the increased mental health (12.66%, 10.72% and 17.90%, respectively). However, the effect of combined intervention focused method was more noticeable on the quality of life (p<0.001) and mental health (p<0.001) compared with two other interventions.

Based on the findings, it seems that any of the Pilates training, vitamin D and combination interventions can improve the quality of life and mental health in overweight people with low levels of vitamin D, but the combination intervention is more effective on these variables.

The role of genetic components in expression of proteins involved in signaling pathways of fat and carbohydrate metabolism has been well-demonstrated. The aim of this study was to determine effects of high intensity interval training (HIIT) on glucose, insulin, and insulin resistance levels as well as IRS1 expression in gastrocnemius muscle of obese Wistar rats.

The study included 14 male, Wistar rats (aged 10 weeks) weighting 220 ± 20 g. Obesity was induced in all rats via exposure to a high-fat diet for six weeks. Then, the rats were randomly divided into a HIIT group (n=7) and a control group (n=7). The rats in the HIIT group performed treadmill running, five sessions a week, for eight weeks. Levels of fasting glucose, serum insulin, insulin resistance, and IRS1 expression in the gastrocnemius muscle of the rats were measured after the last training session. Data were analyzed by the independent t-test at statistical significance of 0.05.

The HIIT intervention significantly decreased fasting glucose compared with the control group (p<0.0001). It also resulted in a significant decrease in serum insulin levels and insulin resistance compared with the control group (p<0.0001). Moreover, the HIIT training significantly increased IRS1 expression (p=0.030) in the gastrocnemius muscle of rats.

Based on the available evidence, the increase in insulin function and the decrease in insulin resistance can be attributed to increased IRS1 expression in the gastrocnemius muscle following HIIT training.

Type 2 diabetes is a multifactorial disease, with both genetic and environmental factors influencing its prevalence. The aim of this experimental study was to determine the effect of 6 weeks of resistance training on GLP1 expression in pancreatic tissue as well as glucose and insulin levels in type 2 diabetic rats.

The statistical population consisted of all male Wistar rats of Pasteur Institute of Iran, from which 14 10-week-old rats weighing 220 ± 20 g were purchased. The studied rats were exposed to 6 weeks of high-fat diet and STZ injection of type 2 diabetes and were randomly divided into two groups (control and resistance). The resistance group then participated in a resistance training course for 6 weeks with 5 sessions per week. 48 hours after the last training session, fasting glucose and insulin levels and GLP1 expression in pancreatic tissue of both groups were measured and compared by independent t-test. All statistical analyzes were performed using SPSS / Win software version 16.

Resistance training improved fasting glucose levels compared to the control group. Serum insulin levels and GLP1 expression in pancreatic tissue of the resistance group increased significantly compared to the control group. Significant level of α = % 5 was considered.

Based on the findings of this study, increased serum insulin in response to resistance training in T2D rats may be attributed with increased Mafa expression in pancreas tissue.

Foxo1 is a transcription factor in insulin signaling in the liver. The function of Foxo1 is important in the ability of insulin to regulate hepatic glucose production and glucose homeostasis. The aim of this study was to determine the effect of resistance training program on Foxo1 expression in liver cells as well as glucose and insulin serum levels in male Wistar rats with type 2 diabetes.

The statistical population of this experimental study was 10-weeks old, male Wistar rats weighing 220±20 g (n=14). The studied rats were subjected to 6 weeks of high-fat diet and STZ injection for type 2 diabetes induction and then rats were randomly divided into two groups (control and resistance). The training group participated in a resistance training course for 6 weeks, 5 sessions per week, in the form of 4 sets and 5 repetitions per set, climbing a 26-step ladder to a height of one meter with a vertical slope of 80%. Finally, 48 hours after the last training session, fasting blood  glucose and insulin levels as well as Foxo1 expression level  in liver cells of both groups were measured and compared by independent t-test (a=%5).

The resistance training improved fasting blood glucose compared to control subjects (p>0.001). the serum insulin levels were significantly increased (p=0.042) and Foxo1 expression significantly decreased in resistance group when compared with control subjects (p=0.023).

Based on these data, the decrease in glucose concentration in the exercise group can probably be attributed to the decreased expression of Foxo1 in hepatocyte cells in response to resistance training.

Increased Mafa expression with increased insulin secretion from pancreatic beta cells and consequent improvement in glycemic profile in type 2 diabetic patients. This study aimed to determine the effect of resistance on Mafa expression in pancreas tissue, glucose and insulin in type 2 diabetes rats.

The statistical population consisted of all male Wistar rats of the pastor inistitue of Iran, among which 14 were male rat 10 weeks old weighting 220 ± 20 g. Type 2 diabetes induced by Intraperitoneal injection of nicotinamid + STZ. Then rats divided randomly into resistance (6 weeks, 5 times/weekly, n=7) and control (n=7) groups. Fasting glucose, serum insulin and Mafa expression in Pancreas tissue of both groups were measured after lasted exercise and compared between 2 groups by independent T test.

Resistance training significantly reduced fasting glucose and significantly increased serum insulin levels compared with the control group. Resistance training also increased Mafa expression in pancreatic tissue( p>0/0001).

Based on these data, increased serum insulin in response to resistance training in T2D rats may be attributed with increased Mafa expression in pancreas tissue.

The aim of this study was to determine the effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats. A total of 28 male Wistar rats were randomly divided into 4 groups; saline injected control (Control), resistance training+saline injected (Training), resistance training+IGF-1 injected (Combined) and IGF-1 injected (Injection). Resistance training protocol consisted of climbing (three days/week, 5 reps/3 sets) a ladder carrying a load suspended from the tail for 8 weeks. IGF-1 and saline (1.5 µg/kg/day) were injected before and after exercise sessions. Three days after the last bout of exercise, colorectal tissues were collected and gene expression levels were analyzed using real-time PCR. In Training, Combined and Injection groups, p53 expression in the colorectal decreased compared with Control (p<0.05). A significant decrease of Cox-2 protein levels was observed in the Training group from the Control (p=0.002). Cox-2 levels were significantly higher in Injection group compared to Control group (p=0.002). In the Combined group, Cox-2 levels was significantly higher compared to Training group (p=0.018). Taken together, this study demonstrates that IGF-1 injection decrease and increase p53 and Cox-2 expression in the colorectal of mice, respectively. However, resistance training decease p53 and Cox-2 expression, also attenuate decrease and increase p53 and Cox-2 expression altered by IGF-1 injection.

Inactivity, obesity and hormone disorders can lead to various diseases in obese and non-athletic individuals. The objective of this study was to investigate effects of six months of aerobic exercise on serum levels of insulin, growth hormone (GH) and insulin-like growth hormone 1 (IGF-1) in sedentary obese women.

In this quasi-experimental study, 15 inactive, obese (body mass index >30) women aged 37-47 years were selected from employees of the Ferdowsi University in Mashhad (Iran), via purposive and available sampling. The participants were randomly divided into an experimental group (n=10) and a control (n=5) group. The experimental group performed 60 minutes of aerobic exercise at 55-65% of heart rate reserve, three sessions a week, for six months. Serum GH, IGF-1 and insulin levels were measured in both groups before the first training session and after the last training session. The Shapiro–Wilk test and the Levene's test were used to assess normal distribution of data and homogeneity of variance, respectively. Independent and dependent t-tests were used to compare between-group and within-group differences at significance of 0.05. All statistical analyses were performed using the SPSS software (version 18).

Serum concentrations of IGF-1 and insulin reduced significantly following the six-month aerobic exercise program. In addition, the exercise training caused an insignificant increase in GH levels.

Our proposed aerobic exercise protocol significantly reduces IGF-1 level, which is closely related to the incidence of atherosclerosis, breast cancer, and colon cancer. The significant decline in insulin secretion following the six-month aerobic exercise program may provide more amounts of nutrients for muscle glucose metabolism.

Cardiovascular disease is the leading cause of death worldwide. This study examined the effects of cardiac rehabilitation exercise on lipid profile and expression of peroxisome proliferator-activated receptor alpha (PPAR-α) gene in patients who underwent coronary artery bypass grafting.

In this quasi-experimental study, after screening, patients who underwent coronary artery bypass grafting (CABG) were randomly divided into an experimental group (n=12) and a control group (n=12). After the surgery and discharge from hospital, the experimental group performed rehabilitation exercise for two months, while the control group did not perform any exercise after discharge from the hospital and the initial phase of rehabilitation. Fasting blood samples were collected before and after the last training session to evaluate biochemical variables and PPAR-α gene expression of lymphocytes. PPAR-α expression level was assessed by qRT-PCR. Statistical analysis was done in the SPSS software (version 20) using repeated measures.

In the follow-up after the two-month cardiac rehabilitation exercise, the PPAR-α gene was significantly overexpressed and plasma HDL levels increased significantly in the training group compared with the control group (P0.05).

The results indicate that the protocols carried out in the study could be utilized for improving HDL levels and cardiovascular function in CABG patients.

The aim of this study was to investigate the effect of eight weeks of aerobic exercise on serum iron, serum ferritin, platelet count, mean platelet volume, and some immunity indices in non-athlete females. In this study, 30 non-athlete females aged 30-45 years were randomly divided into an experimental and a control group. The experimental group was subjected to perform aerobic exercise at 60-70% of maximal heart rate for eight weeks, three sessions per week and one hour per session. Blood parameters were measured before the exercise program and after the completion of program by taking 2 ml blood samples from the venous vein of the participants in the sitting position. Finally, t-test was used to compare the pre-test and post-test means of each group and independent t-test was used to compare the two groups at significance of 0.05.
After eight weeks of aerobic exercise, there was a significant increase in mean platelet volume and a significant decrease in serum iron and ferritin levels in the experimental group (P We recommend physical education instructors, athletes and non-athletes to consider iron supplementation during aerobic exercise, and modify appropriate training intensity based on the fitness and age of trainees to prevent risk of anemia.

We studied effects of eight weeks of resistance training and IGF-1 injection on serum level of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio in Wistar rats.

We randomly divided 28 male Wistar rats into four groups of saline-injected control (C), resistance training놩抝 injection (RS), resistance training⁡1 injection (RI) and IGF-1 injection (II). Resistance training protocol consisted of climbing a ladder (three days/week with 5 reps/3 sets) while carrying a weight suspended from the tail for eight weeks. IGF-1 and saline (1.5 µg/kg/day) were injected before and after exercise sessions. Serum IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio and morphology of colorectal tissue were evaluated.

Serum IGF-1 level and IGF-1/IGFBP-3 ratio decreased in the RS group compared to the other groups (P The resistance training reduces IGF-1 and increases IGFBP-3 levels, which might represent a link between resistance training and lower risk of colorectal cancer.

Aim: The purpose of this study was to examine the response of the visfatin to acute endurance exercise pre and post 8-weeks trainingin untrained obese healthy men.
Twenty two subjects (age 29.06±3.83 years, weight 90.96±4.68 kg, height 171.3±4.88 cm, and BMI 30.76±1.8 kg/m2) were volunteered to participate in the current study. The subjects were divided randomly into two experimental (n=11) and control (n=11) groups. Experimental group participated in 8-week endurance training program three times per week. Exercise intensity increased from 60 percent of maximum heart rate to 65 to 70 percent after 4thweeks until the end of training program. Acute exercise test (cycle ergometer exercise, 30 min at 60 percent of maximum heart rate) were employed before and after training period. Blood samples were collected before, immediately, and 30 min after acute exercise at before and after endurance training period to measure plasma visfatin variations.
The results by two-way Anova with analysis showed before training period, visfation levels changes were not sigificant after acute exercise , immediately and 30 min aftery in both groups.
These data indicate that endurance training is associated with decrease in resting plasma visfatin and body fat in obese men. Moreover, one bout of endurance training can decrease the plasma visfatin in response to acute exercise.

Recently، energy drink consumption by athletes has become increasingly popular. Athletes believe that energy drinks can be used to enhance their performance during training and competition due to their potentially ergogenic ingredients such as carbohydrates، caffeine، sodium and taurine، among others. Therefore، the purpose of this study was to determine the effectiveness of the acute ingestion of a taurine and caffeine-containing drink on Wingate cycle performance and blood lactate levels in active men. A sample of 19 active male students (age: 8/0±3/22years، height7/6±2/71: cm، weight: 4/5±9/175kg) from Mazandaran University were selected. This research was conducted on two separate sessions with four days rest in between. In the first session، all of the subjects participated in the Wingate test، after having a standard breakfast، and after the blood taking (before and 2 min after test) and hand muscle esterangth measurement. In the second session، subjects were randomly divided in three groups (taurine and caffeine-containing drink، placebo and no drink groups). Immediately after having breakfast (forty minutes prior to test beginning)، each group received 6 ml/kg. bw of related beverages. In the taurine and caffeine-containing drink group، minimum (p=0/017) and mean (p=0/029) power was increased and blood lactate before (p=0/357) and after (p=0/920) the test، was unchanged Conlusion: In conclusion a commercially-available taurine and caffeine-containing drink (Red Bull) enhances anaerobic power of active male.

Serum Alkalin phosphatase (ALP) is an osteoblastic protein whose levels may be affected by exercise. Research has shown that exercise may increase bone density through increasing the level of bone constitute markers such as calcium, phosphor, and ALP. The aim of the present research was to compare the markers of the bone metabolism (calcium, phosphor, and ALP) between 20-35 year-old female basketball players and non-athletes in Golestan province. 12 female, professional basketball players and 15 non-athletes participated in this study as the experimental group and the control group respectively. To study the intended markers, 5 cc of blood was collected from the archival vein of the participants in a sitting position. To analyze the data, shapiro wilk, mann whitney u and independent T-test were used. SPSS software version 18 was used to analyze the data. The significance level was set at p

The results of researches have shown that blood components and elements may change by performing various physical exercises, such that some of these changes can result in anemia in both athletes and non-athletes individuals. The present study aims to investigate the effect of 8 weeks of aerobic training on VO2max and hematologic indices in 30-45 year old non-athlete women in the city of Galugah. The method of this study is quasi-experimental including a pre-test and post-test with a control group. The participants of the study consisted of 30 non-athlete women with Mean (age of 36.9 ± 4/5 yrs, weight of 74.09 ± 11/9 kg, height of 158.30 ± 4/9 cm and BF= 39/55± 11/5). The training protocol included 8 weeks of aerobic training (3 sessions per week, each comprising 60 minutes running exercise at 60-70% maximum heart rate across 1600 meters). In order to investigate the studied variables Blood samples were collected and examined during 2 phases, both before and after 8 weeks of training protocol. Dependent t test was used to compare the pre-test and post-test obtained means of each group, and independent t test was applied to compare the groups at α=0.05. following 8 weeks of aerobic training, RDW changes (RBC distribution range) was not significant despite significant increases in VO2max, RCB, HCT and Hb as well as significant decreases in iron, ferritin, MCV, MCH and MCHC. VO2max values significantly increased in the experimental group comparing with the control group. Ferritin, iron, RBC, MCV and MCH values significantly decreased in the experimental group in the post-test comparing with the control group whereas Hct, Hb and RDW values increased in the control group comparing with the experimental group, though the variations were not significant. And also the MCHC values of control group in the post-test had an insignificant increase compared with the experimental group. Discussion and Results have shown that aerobic training can cause variations in hematological indices in middle-aged women. And also aerobic training not only has favorable effects on cardiovascular adaptation, but also is the most effective factor in increasing aerobic capacity (Vo2max).