dr jafar mobaleghi

Trauma is one of the world''s most important public health challenges. Considering the advances made in technology and industrialization of societies in the last century، trauma and its complications have been regarded a major problem because، it is the most common cause of death and disability in people between1 and 44 years of age. The aim of this study was to determine trauma patterns in the trauma victims treated at Besat Hospital in Sanandaj in 1390. This was a descriptive–analytical study and included 4016 patients who had referred to Besat Hospital in Sanandaj due to trauma. Data were entered into SPSS V. 18 software and analyzed by descriptive statistics and chi-square test. We used Mann-Whitny U test for the variable of age because distribution of age was not normal. 1263 patients (31. 4%) were female and 2753 (68. 6%) were male. The mean age of the study population was 31. 7 ± 19. 6 (age range: 1 month to 90 years). 131 patients (3. 3%) had penetrating and 3885 (96. 7%) had blunt trauma. 20 patients (0. 5%) died from trauma related injuries. Patterns of trauma had significant relationships with gender and type of traumatic event (p<0. 001). There was also a statistically significant relationship between age and trauma patterns (p = 0. 006)، but the patterns of trauma and trauma-related deaths did not show any statistically significant relationship (p = 0. 410). The rate of traffic accidents is high among the young people who are the most active and competent group in the society. Prevention of These accidents requires meticulous planning. Well-equipped emergency rooms can have an important role in the reduction of mortality rate due to trauma related injuries.

Here we examined the expression of self renewal regulatory factors such as, Esrrb, Tcl1, Tbx3 and Dppa4 in several tissue samples of cancers and cancer cell lines. These genes are required for efficient self renewal of embryonic stem cells.

Caco2, HT-29, HT1376, Ln Cap, and HepG2 cells were cultured in T25 flasks. Considering the clinical and laboratory findings, human tumor samples were obtained under direct supervision of the medical specialists. Then we evaluated expression of self renewal genes (Tbx3, Tcl1, Esrrb, Dppa4) by reverse transcriptase polymerase chain reaction (RT-PCR) in the above mentioned cells and human tumor samples. To confirm the validity of the laboratory tests, we studied negative control samples and internal control genes.

Our data revealed the expression of self renewal genes (TCL1, TBX3, ESRRB and DPPA4) in bladder, liver, prostate and colon cancers and also cancer cell lines.

Colon, liver, prostate and bladder cancer cells can express TCL1, TBX3, ESRRB and DPPA4 genes, which are specific markers of stem cells. Therefore in malignant cells of the above mentioned cancers, some cells have the characteristics of stem cells and can play an essential role in the proliferation of malignant cells.