فهرست مطالب dr yousef rasmi

Gastric cancer is one of the common gastrointestinal cancers with global incidence and one of the most common cancers in the northwestern of Iran. This study aimed to determine the prevalence of gastric tumors and their anatomical location using the pathologic specimens of patients have been conducted in Urmia. The study population comprised all samples sent to Pathology Laboratory of Imam Khomeini Hospital، Urmia; in a 5- years period during 2002-2007 were studied، and their documents are available. Information extracted included: age، sex، smoking habit، type of surgery، tumor location and histopathology of tumor type. data were analyzed by using SPSS software. Of 452 patient samples in this study، 336 were men. The most common age of stomach cancer observed in both men and women over 70 years with prevalence 42. 7% and 34. 74%، respectively. 33. 9% of men and 23. 0% of women were smoker. Regarding to type of surgery، 88. 0% of patients undergoing biopsy and 12. 0% gasrtoctomy. Histophatologically، incidence of adenocarcinoma، squamous cell carcinoma and Round cell was 95. 5%، 4. 04% and 0. 46%، respectively. Incidences of adenocarcinoma in men were three-fold greater than women. Lasser sace، cardia، antrum، fondus and other overlapped locations showed tumor involved (with number of samples prevalence of) 155 (35. 9%)، 114 (26. 4%)، 84 (19. 4%)، 40 (9. 3%) and 39 (9. 1%)، respectively. According to this study، adenocarcinoma is most common cancer in Urmia. Most common anatomical distributions locations are Lasser sace and Cardia.

Chronic obstructive pulmonary disease (COPD) is considered as a systemic disease by chronic inflammation with exacerbation episodes. Fibrinogen is a marker of systemic inflammation. The aim of this study was to assess the relation between plasma of fibrinogen level with adverse outcome in COPD patients. In this cohort study patients with acute exacerbation of COPD admitted to pulmonary ward were studied prospectively. They were divided into two cohort، patients with high plasma fibrinogen (>400 mg/dl) and less than 400 mg/dl on admission day venous blood. The patients were followed for duration of hospitalization and any adverse outcome (death in the hospital، transfer to ICU، intubation and mechanical ventilation). Relation of fibrinogen level with outcome evaluated. Among 54 patients، 15 had adverse outcome، and 39 good outcomes. Among these two groups، the mean plasma fibrinogen was 530±256. 43 mg/L and 155. 67±96. 55، respectively (p=0. 001). In 14 patients plasma fibrinogen level was >400 mg/dl and in 40 patients ≤ 400 mg/dl The rate of adverse outcome was 85. 7% in 7. 5% in those with higher and lower fibrinogen level (p value=0. 001). The mean duration of hospitalization was 13. 7±5. 27 vs. 5. 02± 2. 06 days in fibrinogen > 400 mg/dl and ≤ 400 mg/dl group respectively (p value=0. 001) Plasma fibrinogen obtained at admission day may assist identification of high-risk patients with acute exacerbation of COPD.

Endothelial dysfunction is found in early steps of atherosclerosis and is related with diseases such as hypertension, dyslipidemia, and insulin resistance. Insulin resistance is related to metabolic abnormalities. We aimed to examine influence of impaired fasting glucose on endothelial function biomarkers and biochemistry biomarkers in metabolic syndrome patients. This study was conducted on 80 patients with metabolic syndrome (MS) diagnosed based on the NCEP Adult Treatment Panel III. Subjects were divided into two groups; 36 MS patients with Fasting Blood Sugar (FBS) ≥ 100 mg/dl; and 44 patients with FBS <100 mg/dl. In order to evaluate endothelial function, plasma Endothelin-1, intercellular adhesion molecule (ICAM-1), E-selectin, (NO2▬) and Nitrate) NO3▬) concentrations were measured. The mean age in patients with FBS ≥ 100 mg/dl and <100 mg/dl were 51.58 ± 8.82 and 46.77 ± 10.46 years, respectively. (P= 0.031) In cholesterol, LDL-c, HDL-c, levels were similar in two groups. E-selectin plasma level was significantly higher in patients with FBS ≥100 mg/dl (11.67±4.81) compared with patients with FBS <100 mg/dl (9.61 ± 4.41 p= 0.049) and in patients with FBS ≥100 mg/dl NO2-, NO3- were 15. 85 ± 4.67, 16.96 ± 6.3 uM, respectively and in patients with FBS <100 mg/dl were 19.65 ± 7.41, 21.25 ± 10.81 respectively, in NO2- p= 0.010, in NO3 p= 0.039 that were significantly lower compared with patients with FBS <100 mg/dl. Endothelin-1 and ICAM-1 were similar in two groups. MS patients with impaired fasting glucose had higher level of E-selectin and this factor may induce endothelial dysfunction. Insulin resistance may increase NO2- and NO3- in MS patients with high FBS.