فهرست مطالب dr. h. agha alinejad

Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to investigate the influence aerobic interval training on expression of mesenchymal biomarkers, and tumor volume in mice with breast cancer.

In this experimental study, Thirty-two female BALB/c mice, aged 3-5 weeks (17±1g) were used. The mice were allocated to four groups: Exercise Tumor, Exercise (aerobic Interval training was performed six weeks (40 minutes) before and four weeks (30 minutes) after the induction of carcinoma with active recovery), Rest Tumor, Rest (Control- without exercise), Rest, Tumor, Exercise, (four weeks after the induction of carcinoma) and Exercise, Tumor, Rest (six weeks before the induction of carcinoma). The real-time PCR method was used to evaluate the expression of Vimentin and Twist.

The results of present study demonstrated that tumor tissue Vimentin expression in the Exercise Tumor Exercise (223.0±0.073) group decreased significantly (p= 0.0001), Also, the expression of Twist gene was significantly reduced in Exercise Tumor Exercise group (0.24±0.227) compared to control group (p=0.008). A significant decrease in tumor volume was observed in both RTE and ETE groups compared to the control group (RTR) (p = 0.0001).

Based on the results of this study, a period of interval aerobic training can decrease the expression of Vimentin، Twist and decrease the tumor volume ratio.

Obesity and physically inactive lifestyles are associated with an increased risk for developing insulin resistance. It has been confirmed that insulin resistance is a common feature in many inflammatory diseases and can be recognized with overproduced levels of markers such as IL-6, IL-18 & CRP. The aim of this study was to determine whether obesity or inactivity are stronger factors in the develop mental insulin resistance, considering insulin resistance markers such as IL-6, IL-18 and CRP.

Thirty-two healthy, male students participated in the present study, age 24. 8±2. 52 years, height 175. 47±6. 7, and weight 81. 64±20. 14). Weight and body fat were measured with the body composition set and levels of exercise was determined with the PA-Rscore questionnaire. All subjects based on body fat and levels of exercise were divided into 4 groups: Active obese(n=8), active, non-obese (n=8), inactive, obese (n=8) and inactive, non-obese (n=8). To determine fasting values of IL-6, IL-18, CRP, glucose and insulin blood samples were obtained at 8 a. m.

Obese subjects had higher resting levels of IL-6, IL18, CRP and insulin than lean subjects, with no significant difference between active lean and inactive lean subjects at resting levels of inflammatory markers. However there was a significant difference in the resting levels of IL-18 between active and inactive obese subjects (t=-2. 51 P=0. 031), and also a significant difference in resting levels of IL-6, IL-18,CRP, insulin and HOMA between inactive obese with active and inactive lean subjects, IL-18 having the strongest relationship with HOMA (r=0. 54 p=0. 001).

Results indicated that obesity is a stronger factor than inactivity for development of insulin resistance. On the other hand, activity has anti-inflammatory effects, and hence can decrease the effects of obesity, in the development of insulin resistance.