ehsan hejazi
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Due to the lack of definite therapy and prevention protocols for Covid-19, nutrition and exercise are considered preventative measures in dealing with the epidemic. Healthy diets, dietary supplements and exercises boost the immune system. These factors can be effective in improving functions of the immune system. The current study investigated immune-enhancing characteristics of exercises, dietary supplements (proteins, vitamins, minerals, oils, coenzyme Q10 (CoQ10), probiotics, ginseng, antioxidants and Chlorella vulgaris) and food additives (titanium dioxide, sodium nitrite, monosodium glutamate, tartrazine, sweeteners and emulsifiers). The current study investigated functions of dietary supplements and exercises in strengthening the immune system, as well as assessing roles of food additives in illness prevention, particularly Covid-19, when combined with a balanced nutrition strategy. Light exercises, healthy lifestyles and nutritional supplements have been shown to boost the immune system.
Keywords: Covid-19, Dietary Supplement, Exercise, Food additive, Immune System -
Background
Recently, it has been suggested that people’s chronotype is involved in regulating food intake and obesity. This study aimed to investigate the association between chronotypes with hormones related to appetite in adults in Tehran.
MethodsThis cross -sectional study was conducted on 353 men and women aged 18 -60 years using convenience sampling in Tehran municipality community centers. Information on morningness -eveningness choronotype and physical activity (PA) level were collected by validated questionnaires. The data for anthropometric measurements and 3 -day food recalls were also collected. ELISA method was used to assess Neuropeptide Y (NPY) and leptin serum level.
ResultsThe prevalence of eveningness, intermediate, and morningness chronotypes was 11%, 47.6%, and 41.4%, respectively. The participants with eveningness type were significantly younger (P = 0.001). The percentage of men with eveningness type was significantly higher than women ( P = 0.001). The mean values of height, weight, body mass index (BMI), waist circumference, total calorie intake, protein, carbohydrate, fat, and calorie intake from each of the main meals and snacks, were not different among three chronotypes. Leptin and NPY did not show any significant association with chronotypes.
ConclusionIndividual’s chronotype was not associated with NPY and leptin serum level. Further studies on a population with more varied work shifts are suggested.
Keywords: Circadian type, Chronotype, NPY, Leptin, Obesity, Iran -
The aim of this study was to assess the occurrence of Aflatoxins (AFs) including B1, B2, G1 and G2 in commercial cereal-based baby foods by HPLC-FLD method in Iran and related risk assessment in three baby age groups (6-12, 12-18, and 18-24 months) using Monte Carlo simulation approach. Results showed an occurrence ranging from 20% to 60% for B1, B2, and G2 aflatoxins, while AFG1 was not detected in any assessed samples. Exposure and risk assessment was estimated to be two groups (aflatoxin B1 and total aflatoxins). The highest estimated dietary exposure to both AFB1 and total AFs was estimated for 6-12 months aged babies, representing 5.81 ng/kg BW/day and 8.55 ng/kg BW/day, respectively. Overall, the margin of exposures to AFB1 and total AFs were lower than 10,000 in all age groups, indicating a health concern about AFB1 and total AFs exposure through cereal-based baby food consumption. High cancer risk for high consumers (P95) of baby food was also estimated in all age groups, calling for immediate intervention due to serious claims that AFB1, is a highly carcinogenic component, causes hepatocellular carcinoma. Risk ranking results indicated the presence of AFB1 is classified as high risk for babies who consume cereal-based foods, which demands the attention of risk managers to reduce or eliminate this risk for the most vulnerable sector of society, whose aged <24 months.
Keywords: Aflatoxins, Exposure assessment, Risk ranking, Cancer potency, Monte Carlo simulation -
AimThe aim of this study is to examine the relationship between dietary patterns and the risk of Colorectal Cancer (CRC) and adenomas.BackgroundDietary patterns have been shown to be associated with risk of CRC, but there are a few data on this context and its relationship with risk of colorectal adenomas as the precursors of the CRC.MethodsThis hospital-based case-control study was conducted in three major general hospitals in Tehran province, Iran. Data was collected (October 2016 to May 2018) from 129 colorectal cancer and 130 colorectal adenoma patients that confirmed by pathology and colonoscopy findings and 240 controls with non-neoplastic conditions and not afflicted with diet related chronic diseases. Dietary data were evaluated by 147-items semi-quantitative food frequency questionnaire. Multivariate logistic regression was used to estimate the relationship between dietary patterns and risk of colorectal cancer and colorectal adenoma.ResultsThree dietary patterns (healthy, western and traditional) were derived. After adjusting for confounders, the Healthy dietary pattern was associated with a decreased risk of Colorectal Cancer (OR=0.22, 95% CI=0.14-0.37) and Colorectal Adenoma (OR=0.43, 95% CI=0.27-0.69). Higher intake of the Westernized pattern was positively associated with risk of Colorectal Cancer (OR=3.5, 95% CI=2.13-5.19) and Colorectal Adenoma (OR=2.47, 95% CI=1.49-4.08). There was no significant association between traditional pattern and the Colorectal Cancer (OR=99, 95% CI=0.61-1.59) and Colorectal Adenoma (OR=0.85, 95% CI=0.54-1.35) risk.ConclusionOur study suggested that the “Healthy” dietary pattern reduces the risk of Colorectal Cancer and Colorectal Adenoma, while the “Western” dietary pattern increases the risk of both Colorectal Cancer and Colorectal Adenoma.Keywords: Dietary pattern, Colorectal cancer, Colorectal adenoma, Healthy dietary pattern, Western dietary pattern.(Please cite as: Bahrami A, Houshyari M, Jafari S, Rafiei P, Mazandaranian MR, Hekmatdoost A, et al. Dietary patterns and the risk of colorectal cancer and adenoma: a case control study in Iran Gastroenterol Hepatol Bed Bench 2019;12(3):217-225).کلید واژگان: Dietary pattern, Colorectal cancer, Colorectal adenoma, Healthy dietary pattern, Western dietary pattern
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BackgroundEmergence of drug resistance has brought major problems in chemotherapy. Using nutrients in combination with chemotherapy could be beneficial forimprovement of sensitivity of tumors to drug resistance. Soybean-derived isoflavones have been suggested as chemopreventive agents for certain types of cancer, particularlybreast cancer. In this study, the synergistic effects of soy isoflavone extract in combination with docetaxel in murine 4T1 breast tumor model were investigated.MethodsIn this study, mice were divided into 4 groups (15 mice per group) of control, the dietary Soy Isoflavone Extract (SIE, 100 mg/kg diet), the Docetaxel (DOCE, 10 mg/kg) injection and the combination of dietary soy isoflavone extract and intravenousdocetaxel injection (DOCE+SIE). After 3 injections of docetaxel (once a week), 7 mice were sacrificed to analyze MKI67 gene and protein expressions and the rest weremonitored for diet consumption, tumor growth and survival rates.ResultsIn DOCE+SIE group, diet consumption was significantly higher than DOCE group. While lifespan showed a trend towards improvement in DOCE+SIE group, nosignificant difference was observed among the 4 studied groups. Tumor volume was not significantly affected in treated groups. A lower but not significant MKI67 protein expression was detected in western blot in DOCE+SIE group. The mRNA expression was not significantly different among groups.ConclusionThe results suggest that the combination of soy isoflavone as an adjunct to docetaxel chemotherapy can be effective in improving diet consumption in breast cancer.Keywords: Breast cancer, Docetaxel, Soy isoflavone extract
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BackgroundGiven the importance of birth weight and the effects of anthropometric indices and socioeconomic status on it, this study was conducted to assess birth weight and its related factors among infants born in the hospitals of Ahwaz Jondishapour University.MethodsThis cross-sectional study was carried out on 269 newly born babies and their mothers in hospitals of Ahwaz Jondishapour University during 2009. Neonate anthropometric measures were obtained from hospital reports. The mothers were asked about their weight before pregnancy, their weight gain and demographic and socioeconomic data. SPSS software version16 was used to analyze the data. Relationships among infants and mothers’ anthropometric indices were assessed using bivariate correlation.Results86.8% of the infants were normal as to weight, 8.7% were underweight, and 4.5% overweight. Mothers’ weight gain during pregnancy and BMI before pregnancy were 12.18±5.18(kg) and 24.75±4.78(kg/m2), respectively. There was a significant correlation between infant’s birth weight and mother’s weight, height and weight gain during pregnancy.DiscussionResults of this study showed that mothers’ weight before pregnancy and their pregnancy weight gain have a key role in infant birth weight, so controlling the mother’s weight gain according to recommendation has a great effect on infant’s health.Keywords: birth weight, pregnancy, weight gain
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در سالهای اخیر توجه زیادی به نقش سویا و ایزوفلاون های آن در کاهش خطر سرطانها خصوصا سرطان پستان شده است. ایزوفلاون ها دارای خواص شبه استروژنیک بوده و توانایی اتصال به گیرنده های استروژن را دارند. در مطالعات انجام شده تناقصات زیادی در زمینه نقش ایزوفلاون ها در سرطان پستان وجود دارد. عمده این تناقصات مربوط به مطالعات in vitro و مطالعاتی است که در جوندگان انجام شده است. در برخی از این مطالعات ذکر شده که ایزوفلاون های سویا سبب تحریک رشد سلول ها در تومور و افزایش تکثیر سلولی در سلول های سرطانی می شوند. حال آنکه در دیگر مطالعات اثرات ضد توموری و ضد تکثیری ایزوفلاون ها گزارش شده است. از سوی دیگر مطالعات اپیدمیولوژیک همانند بسیاری از مطالعات حیوانی اثر حفاظتی سویا را بر سرطان پستان نشان می دهند. در مطالعات کلینیکی محدود انجام شده در انسان هم هیچکدام اثرات تحریکی ایزوفلاون ها بر رشد تومور یا افزایش تکثیر سلول ها را گزارش نکرده اند. در مطالعات اپیدمیولوژیک انجام شده در افراد بقا یافته از سرطان پستان نیز اثر حفاظتی سویا بر کاهش خطر بازگشت مجدد بیماری و مرگ و میر ناشی از بیماری ذکر شده است. همچنین مشخص شده که استفاده از دوز فارماکولوژیک استروژن در زنان سالم اثر بسیار ناچیزی بر خطر سرطان پستان داشته است. با توجه به استقبال روز افزون مردم از سویا و گنجاندن آن در رژیم غذایی و تسهیل تهیه مکمل ایزوفلاون و با توجه به نگرانی هایی که در مورد اثرات سوء احتمالی نسبت داده شده به آن وجود دارد، لزوم انجام مطالعات کلینیکی بیشتر به چشم می خورد.
کلید واژگان: سویا, ایزوفلاون های سویا, هورمون درمانی, سرطان پستانIn recent years there has been considerable investigation about the potentials of soyfoods to reduce the risk of cancer, particularly breast cancer. Isoflavones are compounds with a chemical structure similar to estrogen and can bind to estrogen receptor. The relationship between soyfoods and breast cancer has become a controversial issue because of concerns -based mostly on some in vitro and rodent data- that isoflavones may stimulate the growth of existing estrogen-sensitive breast tumors. However; some have indicated that soy isoflavones have antitumor and antiproliferative effects. The epidemiologic data are generally consistent with the animal studies, showing no increased risk. In limited clinical studies there is no evidence that isoflavone intake increases tumor growth or proliferation of carcinoma cells. Also, epidemiological studies on breast cancer survival showed that soy isoflavones decrease recurrence and mortality of disease. Furthermore, it is demonstrated that in healthy women the pharmacologic dose of estrogen has very low if any risk for breast cancer. Because of the increasing popularity of soyfoods and the commercial availability of isoflavone supplements and existing concern regarding the estrogen-like effects of isoflavones in the breast, more clinical research seems to be necessary.
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