فهرست مطالب elham abedi

Selenium with antioxidant properties, has positive effects on growth and development of biological activities of many plants but its excessive levels in soil causes physiological problems. This study was conducted to investigate the effect of selenium (bulk) and nanoselenium on some of physiological and biochemical of Vasha, in a completely randomized experiment. Selenium in form of sodium selenate was applied in nutrient solution at concentrations (0, 2.5, 5 and 10 mg L–1) and nanoselenium at concentrations (0, 2.5, 5, 10 and 20 mg L–1). The results showed that application of both bulk and nano-Se treatments significantly increased plant growth parameters (i.e. length of roots and shoot, the root and shoot fresh and dry weights), as well as the content of photosynthetic pigment, total flavonoids, total phenol, anthocyanin and carbohydrate content by 2.5 mg L–1 and 10 mg L– 1 of selenium and nanoselenium respectively. Moreover, the abovementioned concentrations were associated with a significant increase in plant antioxidant activity. All treatments reduced malondialdehyde. The most increase in chlorophyll a was observed at a concentration of 10 mg L-1 nano-Se, which decreased with increasing selenium concentration compared to the control treatment. The results showed that the positive effect of selenium on the growth and increase of phenolic compounds depends on the type and concentration of selenium application.

The purpose of this study is to identify financing strategies in Tehran central library of public universities.

This study in terms of implementation is library then survey, and data collection tools are study texts then a researcher made questionnaire. First, the current status of libraries in terms of funding from the heads or deputies or their representatives point of view is discussed. Then the questionnaires were distributed among the managers and librarians to inform us about their viewpoint about financing strategies. To measure the current situation the study population consisted of all managers and heads of 11 academic universities and the attitude assessment was in a census method. A total of 156 librarians responded to the questionnaires. The analysis of the findings of this study has been done through SPSS.

The findings of the study show that the current strategies used to finance in the central libraries of academic universities of Tehran are not appropriate to the current situation. Besides, it was founded that there is a significant relationship between the main variables of the research, namely financing strategies, and its dimensions, and income-generating activities, financing methods, and training in the financing, respectively, have the greatest impact on financing strategies in university central libraries.

This study for the first time examines the approach of financing in Tehran public university libraries in addition, using the perspectives of managers and librarians, offers some guidelines for financing in academic libraries.

Myeloproliferative neoplasms (MPNs) are heterogeneous disorders with a variety of genetic abnormalities. We aim to assess the prevalence of Calreticulin (CALR) and JAK2 mutations in Iranian MPNs.

In a cross-sectional study, CALR and JAK2 mutations among 130 MPNs patients, including 78 Philadelphia chromosome-negative (MPN-) and 52 Philadelphia chromosome-positive (MPN+) as well as 51 healthy control subjects, were investigated by GAP-PCR.

In MPN- group JAK2 and CALR gene mutations were found in 64.1% and 7.7%, respectively, that 5.1% were positive for both mutations, and 2.6% had only CALR mutation. In polycythemia vera (PV) patients 90% had JAK2 mutation, which was significantly higher than other MPN- or MPN+ patients. Most of the MPN+ patients had neither mutation in CALR nor JAK2 (70% CALR-/JAK2- ). Among all patients’ groups, the prevalence of CALR+ mutation in either rs1450785140 (4 cases) or rs765476509 (5 cases) position was not statistically different.

These results showed a low prevalence of CALR mutations in all types of MPNs in the Iranian population that its frequency may influence by ethnicity and genetic diversity. CALR mutation may be seen in JAK2 negative cases, also. The PV had the highest JAK2 mutation with a 90 percent positivity rate among MPNs cases.

Five epigenetic regulator mutations are considered in myeloproliferative neoplasms (MPN) that have prognostic and therapeutic values.

We aimed to evaluate these mutations in MPNs among the Iranian population

We selected 5 mutations in 4 epigenetic regulatory genes [TET2, DNMT3A, IDH1 (rs147001633& rs121913499), and JAK2)] and evaluated 130 patients with MPNs including 78 Philadelphia chromo - some negative (49 ETs, 20 PVs, and 9 PMFs) and 52 Philadelphia chromosome-positive patients as well as 51 healthy controls.

Eight patients (6.5%) carried the DNMT3A mutation, 35 (27%) were positive for TET2 mutation and 64 (49.3%) had the JAK2V617F mutation. In the healthy controls, 16 (31.4%) cases had the TET2 mutation (15 Heterozygote + 1 Homozygote) and one had heterozygote JAK2 mutation. There was no statistically significant difference between patient groups for any of these mutations, except for JAK2. The JAK2 mutation rate was 18 (90%), 25 (51%), 7 (77.8%), 14 (26.9%) in polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myelocytic leukemia, respectively. Patients aged 60 and older were more likely to carry the TET2 mutation (23% vs. 39% in younger and older than 60 years old individuals, p=0.025). IDH1 was not detected at all and PV had the highest TET2 mutation 7(35%). Two PMF patients had a history of bone marrow transplantation that were negative for IDH1and DNMT3A and one was positive for TET2 mutation.

In the normal Iranian population, the heterozygote form of TET2 mutation is significant, es- pecially in the elderly. No association was found between JAK2 and TET2 mutations. Both of them are more prevalent in the age group of 60 years and older. DNMT3A mutation has a low prevalence and oc - curs in both positive and negative MPNs.

This study aimed to determine the effectiveness of an educational intervention on appropriate pregnancy weight gain in first-time pregnant women attending Khorram Darreh’s urban health centers in 2019.

This was a pretest-posttest quasi-experimental study. The target group consisted of all first-time pregnant women from Khorram Darreh who were covered by its eight urban health centers. Based on the socioeconomic status of the area, the centers were divided into four equal groups. Centers were divided into intervention and control groups using the lottery method. After evaluating the inclusion criteria, the researcher measured the maternal body mass index. The NUTRIKAP questionnaire was used to conduct the pretest on both the intervention and control groups. The education was provided by a trained nutritionist in three hour-long sessions in the first, second, and third trimesters of pregnancy. The posttest was done immediately after training. At the end of the third trimester, the weight of the pregnant women was measured in both groups.

The mean scores of the knowledge and practice indices in the intervention group were significantly higher than the control group (p = 0.001). After the intervention, there was no significant difference between the mean scores of the attitude domain in the intervention and control groups (p = 0.311). There was a significant difference between the intervention and control groups in terms of optimal weight gain during pregnancy (p = 0.015).

The educational intervention was effective in appropriate pregnancy weight gain among first-time pregnant women, addressing the primary prevention approach.

 Water salinity is one of the most progressive environmental factors limiting the growth and productivity of plants. The objective of this study was to evaluate the effects of salt stress on seed germination and some quantitative trait of tall fescue. For this purpose, a laboratory experiment was conducted at seed laboratory, Islamic Azad University, Isfahan Branch. The traits were radicle and plumule length, fresh and dry weight of radicle and plumule and some properties of seed germination such as germination percent, mean germination time, germination speed, and germination energy and vigor index. Seeds were arranged in petri dishes with 4 replications in completely randomized design with six levels of water salinity including 0, 4, 5, 6, 7 and 8 dSm−1. The results indicated that salinity stress had significant effect on seed germination and physiological characteristics. The results indicated that salinity of irrigation water significantly reduced all studied properties exception of germination time. The values of these properties were continuously decreased with increasing salinity levels. However, time of germination in salinity levels of 4−7 dSm−1 was significantly higher than that distilled water. Seed vigor index was more affecting salinity stress than germination percent.   

Among heavy metals, lead is a powerful pollutant that can be easily accumulated in the soil. Zinc is also a heavy metal but the minimum concentrations are required for plant growth. However, excessive amounts of these elements can become harmful to plants. In order to study the physiological traits, several concentrations of Lead (II) chloride (0, 0.5, 2.5, 4.5 and 6.5 mM) with different concentrations of Zinc chloride (5, 10, 15 and 20 mM) was conducted on soybean plant (Glycine max L.) growth biochemical parameters. Results were obtained from a factorial experiment in a completely randomized design with four replications under in vitro conditions. The results showed that the total protein contents decreased with increasing zinc and lead concentrations. This research concluded lead has a negative effect on this plant, and these plants has no tolerant to heavy metals stresses despite this metal uptake by roots and it has negative effects on plant performance.

Oral tongue Squamous Cell carcinoma (SCC) commonly involves males between the sixth to eighth decades of life. Major risk factors are tobacco usage and alcohol consumption. The increasing number of patients developing oral tongue cancer without these well-known risk factors suggests that a viral infection, such as Human Papillomavirus (HPV), may be responsible for this increase, by acting as an oncogenic agent. This study investigated the prevalence of HPV infection and its clinicopathologic significance in oral tongue SCCs.
Material and Tissue blocks from a total of 50 cases (patients with oral tongue SCC) and 50 controls (palatine tonsillar tissues with benign diagnosis) were selected. DNA was extracted from tumoral and non-tumoral tissue blocks. Detection of common HPV DNA by nested Polymerase Chain Reaction (PCR), and high-risk genotypes, HPV 16 and HPV 18, by conventional PCR, was achieved and the results correlated with clinicopathological parameters.
Of the 50 patients (18 males and 32 females with a mean age of 57.36±12.18 years, and age range of 27 to 86 years), 7 (14%) had HPV positive results. None of the control group subjects had HPV DNA positive results (P-value of 0.012). The HPV genotype 16/18 was not detected in positive cases. No statistically significant association was found between HPV status and gender, age, tumor grade, tumor stage or lymph node involvement.
Although there was a significantly higher prevalence of HPV in oral tongue SCC, its association with carcinogenesis in this area requires further studies.

Statement of the Problem: Sinonasal papilloma (SNP) is a rare benign lesion characterized by high recurrence rate and malignant transformation. This study aimed to investigate the prevalence of human papilloma virus (HPV) infection in these lesions in South of Iran. In this cross sectional retrospective study, a total of 41 patients, 38 SNP and 3 SNP/Squamous cell carcinoma cases, from 2007 to 2014 were studied. Human papilloma virus (HPV) DNA detection was performed by nested PCR method and positive cases were analyzed for high risk HPV-16 and HPV-18. HPV was detected in 31.7%; HPV- 16 in 4.9% and HPV 18 was not detected at all. Dysplastic epithelium was detected in 53% that was not associated with HPV. Three cases were accompanied with malignant transformation that HPV genome was detected in only one case and none of them were positive for HPV16 /18 genomic DNA. Current research suggests that HPV may be involved in the development of SNP. But the high risk HPV is not important in malignant transformation. More studies are needed to elucidate the possible etiologic mechanism between HPV, inverted papilloma, and squamous cell carcinoma.

A match of the student's traits and teaching and training styles of sport skills has received researcher's attention. The aim of the present study was to investigate the interaction of physical self-concept and coach-oriented and self-regulated training styles in acquisition, retention and transfer of volleyball serve of collegiate female students. 50 female students (age: 18-25) were assigned to high and low physical self-concept groups. Then, each group was divided into coach-oriented and self-regulated styles. Participants exercised the criterion task for 6 weeks, 4 sessions per week in their special training condition. AAHPERD test and Physical Self-Concept Questionnaire were used for data collection. Acquisition tests were administered every week while retention and transfer tests were administered 3 days after the last training session and one hour after the retention test respectively. The data were analyzed by ANOVA with repeated measures and ANOVA. Results showed that the high self-concept group practicing the task with self-regulated style showed the best performance in acquisition, retention and transfer phases. The other groups showed similar performances. Results clearly showed that participants with high physical self-concept who exercised volleyball serve skill with self-regulated style had the highest skill acquisition and learning.

A probability based assessment procedure has been proposed in this study aiming to take into account the stochastic nature of explosive loading and different blast scenarios. It is first necessary to identify the structure behavior against the explosions and probabilistic assessment of responses considering the structural and loading uncertainties. A reinforced concrete building has been considered to evaluate the efficiency of proposed approach in this study. The ANSYS Autodyn Ver.14 software has been utilized for modeling and analysis under blast loading and the damage level of structure has been specified using the pressure-impulse diagrams and the structural fragility curves dependent on the explosive weight and scaled distance have been utilized to evaluate the structural reliability. The sensitivity of the probability of structural failure respect to the uncertainty parameters of blast loading indicates that the uncertainty parameters related to the blast loading are more important in comparison with the uncertainties in structural characteristics. In general, the reliability analysis of the existing buildings can be an appropriate way to decide for repairing or renovating of the structure.

To determine the prevalence of various types of conjunctival lesions, at a tertiary ophthalmic center in Fars Province, South of Iran. Histopathologic slides and medical records of conjunctival lesions submitted to the pathology department of Khalili Hospital, Shiraz, Iran were reviewed from April, 2009 to July, 2013. The histopathologic diagnoses were categorized into benign, pre-malignant, and malignant lesions. The prevalence of various types of conjunctival lesions was calculated. Histologic sections of 631 conjunctival lesions were reviewed. Benign lesions were most prevalent (81.8%), followed by premalignant (10.8%) and malignant (7.4%) lesions. Pterygia were the most common benign lesions (69.2%), intraepithelial dysplasia constituted most cases of premalignant lesions (94.1%), and squamous cell carcinoma was the most frequent malignant lesion (93.6%). Benign lesions were the most common type of lesions in all age groups, however the prevalence of malignant lesions increased significantly with age (P < 0.001). Benign lesions were the most common conjunctival lesions with pterygia on top of the list, while intraepithelial neoplasia and squamous cell carcinoma were the most common premalignant and malignant lesions, respectively. Conjunctival malignant lesions were more prevalent with older age.

Primary Small round blue cell tumors (SRBCT) in sinonasal comprise histogenetically diverse entities with overlapping morphologic features. Because of the limited initial biopsy tissue materials, differential diagnostic difficulties may arise, and as they have different management, exact diagnosis and classification are very important.. In this study, we analyzed the immunohistochemical expression of a panel of markers in the classification and diagnosis of sinonasal SRBCTs.. This cross sectional study was performed on 36 paraffin embedded tissue samples. Histologic and immunohistochemical slides from 36 patients with SRBCT were analyzed retrospectively. The patients were admitted in Khalili hospital, Shiraz from 1383 to 1388.. There were 13 women and 23 men with the mean age of 53 ±12.1. There were 9 malignant melanoma, seven poorly differentiated SCC; six lymphoma (DLBL); 4 SCNEC; three SNUC; two ON; two Ewing/PNET; two embryonal rhabdomyosarcoma, and one plasmacytoma. Pan-cytokeratin was strongly expressed poorly differentiated SCC and all cases of SNUC. Coexpression of desmin and nuclear myoD1 was only detected in rhabdomyosarcoma. HMB45 was only expressed in sinonasal melanoma. CD99 expression was identified only in Ewing/PNET. FLI-1 was detected in 50% of PNET. P63 was expressed in poorly differentiated SCC (2/7) and SNUC (1/3).. The results of our study indicate that the integration of histopathologic findings with application of limited but highly specific markers led to the separation of carcinomas, lymphoma and melanomas from other small cell tumors. Using a panel of keratin, LCA, desmin, and HMB45 is the most practical and economic approach to accurately classify these tumors..

Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract. The nasal cavity and nasal septum are the most common sites of occurrence. In this report, three patients admitted in our clinic with history of nasal obstruction and/or epistaxis. Patients were diagnosed with extramedullary plasmacytoma and mass were completely excised. This entity usually occurred in 5th-6th decade of life. One of our patients, a young man, was completely asymptomatic and following a paroxysm of coughing, a polypoid mass was expectorated. The clinical and histopathologic findings of plasmacytoma are discussed. In order to exclude systemic involvement, systematic approach using clinical, laboratory, and radiologic investigations was performed. Extramedullary plasmacytoma of the nasal cavity is rare and should be considered in the differential diagnosis of nasal cavity masses especially in young age group.

Epstein Barr Virus (EBV) is one of the most common viral infections in human population. EBV has a significant role in pathogenesis of Hodgkin''s lymphoma, Burkitt''s lymphoma and nasopharyngeal carcinoma. The role of EBV in non-Hodgkin’s lymphoma, diffuse large B cell (NHL - DLBL) in the head and neck is controversial.. The purpose of this study is to find out the difference between the presence of Epstein Barr virus in nodal and extra nodal lymphoma of head and neck..Patients and A total of 30 cases of DLBL in two separate groups were collected from pathology department. The first group was consisted of 15 patients with DLBL of neck lymph node and the other was consisted of 15 patients with extra nodal DLBL of head and neck mainly in palatine tonsil. Both immune-histo-chemical (IHC) study and polymerase chain reaction (PCR) for detection of late membrane antigen (LMP) were performed on formalin fixed paraffin embedded tissue.. All 30 cases were negative for EBV in IHC method. But in PCR method, 10% of patients were positive for LMP gene. There were 2 positive cases in nodal lymphoma and 1 positive case in extra nodal lymphoma group.. Compare with PCR method, it seems that IHC is not a sensitive method for detection of EBV. Overall, the finding of EBV in NHL depends on site, type of lymphoma and the detection method..