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Following the evaluation carried out by Mr.Mohsen Mosa-Vand on three articles of Safineh, some answers were given which are mentioned in this article. In these answers, the best attempt is made to explain teaching of Quran-Sufficiency and answer some ambiguities.

Esophageal cancer (EC) is one of the deadliest malignancies worldwide. Esophageal squamous cell carcinoma (ESCC) constitutes the most common type of EC in Asian countries. Despite advanced surgical techniques, 5-year survival of the affected patients is very low. Therefore, identification of genetic factors and cellular regulatory pathways, including microRNAs (miRNAs), in esophageal carcinogenesis is necessary for early detection. MiRNAs are a class of small non-coding RNA about 18-24 nucleotides in length that negatively regulate gene expression. Deregulation of miRNAs was shown to have a crucial role in the pathways underlying tumorigenesis and tumor progression. Evidence indicates that aberrant expression pattern of miR-100 is associated with pathogenesis of ESCC. The function and expression pattern of miR-100 in ESCC are controversial and its effects in tumor progression has not been fully elucidated. A better understanding of molecular procedures mediated by miR-100 in carcinogenesis, may lead to the opportunity of exploring potential miR-100 based therapeutic applications. In this review, we provide an overview of miR-100, including its important regulation pathways and target genes involved in the development of cancers, emphasizing on its potential role in ESCC.

The technological advancement of new information and communication devices, specially virtual social networks, has played a deinitive role in communicating and transmiting information between the individuals born in 1980s. This research underestanding the structure of lived experience of the virtual social networks users, analyzed the main elements of social ethics and how it is revealed in the users’ social behavior. The research method is qualitative using the empirical phenomenology approach, and data gathered through deep interview from 15 graduate students born in the 1980s selected by targeted sampling. The research findings include a central indicator of "dispersion-based social ethics”, which its main features are "combined social identity", “feeling social frustration, confusion and perplexity”, “continuesly comparing oneself with ones born in 1990s”, “glamoring of virtual social networks”. The results also showe that social ethics amongst thepeople born in the 1980s is a mixture of moral actions that originate from economic, social, cultural, political and historical conditions of people born and lived in this decade. Finally, the results indicate that compliance with social ethics is bad, hard and difficult during life.

To determine the epidemiology of injuries of the motorcyclists in road traffic accidents (RTIs) between 2008 and 2014 in East Azarbayejan province of Iran.
A cross-sectional study was performed in East Azerbaijan province in Imam Reza hospital on motorcyclists subjected to injuries in RTIs between 2008 and 2014. Demographic characteristics (age, sex), duration of hospitalization, final status of injured people after discharge from the hospital, admission ward, number of admissions due to injuries in RTIs, nature of injury, and the clinical services provided to injured people were gathered from hospital information system (HIS). Demographic characteristics (age, sex), duration of hospitalization, final status of injured people after discharge from the hospital, admission ward, number of admissions due to injuries in RTIs, injured site of the body, nature of injury, and the clinical services provided injured people were gathered from HIS. Standardized data collection form was used for uniform handling of the data.
Most of the victims (94.4%) were male. The most frequent injuries pertained to the age group of 18-30 with 1676 (51.4%) injuries. Head, abdomen, lower back, lumbar spine, and pelvis, were the most common injured sites, respectively. Reduction of fracture and dislocation and cranial puncture were the most common provided services. The lowest survival time belonged to the age group over 60 years old.
Injuries to the head are the most prevalent injuries among motorcyclists in RTIs. So it is suggested that proper interventions be implemented to ensure wearing helmet by motorcyclist and pillion passengers.

Nowadays tuberculosis (TB) is one of the public health concerns in Iran. The present study aimed to examine the clinical epidemiology and treatment findings of tuberculosis in Babol, Northern Iran.
Methods & Materials: This cross-sectional study was carried out on medical records of tuberculosis registry pertained to Health Center of Babol, Mazandaran province, Iran. The investigated variables included demographic characteristics and some clinical patterns. To present the findings the descriptive statistics such as mean (standard deviation, SD) and frequency (and relative frequency) were used. Analytical statistics was applied by using chi-square test and independent samples Student’s t-test.
The average age of 200 patients infected with tuberculosis was 47.5 years (SD = 21.4), and 58.5% of the cases were male. In both genders, age groups 18-38 years comprised the greatest percentage. During the 5 years study period, 95% of the patients received treatment protocol 1 (including new cases with positive smear, negative smear, and extra-pulmonary). At the end of treatment, 90.5% were improved or treatment period was completed. The most important clinical symptoms in referring the patients to the therapeutic centers were cough (75.1%) and fever (60.9%).
Education and giving information to general population about the most important clinical symptoms of tuberculosis such as fever and cough might be effective in early detection and prevention of Mycobacterium tuberculosis. Then effective treatment might decrease the burden of the disease.

Animal bites are potentially harmful for people. The present study was conducted to describe some of epidemiological patterns and analyse some aspects of animal bites in Maku County in time period 2003-2012.
Material and The longitudinal study was done on recording medicals in Health Center of Maku County, during 2003-2012 years. Interested variables in the study included: demographic characteristics, time patterns, place of injuries, type of injuries incurred to the children, and receiving health care after of bites were gathered. The results presented with descriptive indices such as mean (±SD), frequency (Relative frequency); and analytical statistics presented with the chi-square test and independent t-test.
Age mean of participants was 7.06 (± 2.40) years. 75% of victims were boys and sex ratio of boy to girl was 2.99. The highest percentage of the animal bites occurred by the domestic animals, 93.49% of injuries by the dogs and the highest proportion in the regional rural were occurred. 41.16% of animal bites were happened afternoon (12-18 p.m.). Site of the body injury 60.95% of injuries were from lower extremities. 73.5% of injuries, systematically, referred to receiving services of rabies vaccine.
The present results showed that the most animal bites were related to dogs, and the highest percentage of animal bites was happened in rural area, consideration should be done to control and prevent this health threat.

To describe the epidemiological and clinical characteristics of fall injuries in East Azerbaijan، Iran. This cross-sectional study was based on Hospital Information System (HIS) data for patients referred to the Imam Reza Hospital between 2008 and 2013. We recorded the demographic characteristics and epidemiological patterns of patients who were admitted to our center due to fall injuries. To standardize the reports the International Classification of Diseases (ICD)، the International Classification of Diseases 9 Clinical Modification (ICD-9-CM) was used. Equally، the hospitalization period and number، admission ward، and the final status of victims after discharge from the hospital were extracted from the HIS. Overall we included a total number of 3397 patients with mean age of 39. 2±22. 7 years. There were 2501 (73. 6%) men among the patients. Long bone fracture (48. 1%) and intracranial injury (24. 2%) were the most frequent injuries among fall injury victims. Operations on spinal cord and spinal canal structures (12. 0%)، Operations on nose (11. 6%) were the most common operations being performed in these patients. The survival was significantly lower in patients with age more than 60 years when compared to other age groups (p=0. 001). The survival rate was significantly lower in age group of >60 years، compared to other age groups (p=0. 001). Given the high rate of fall injuries and death among the elderly that increases with age، appropriate measures must be taken to control and prevent injuries while prioritizing the elderly.

According to the previous studies، about 90% of accidents in the workplace are due to the unsafe behaviors. In this study، the impact of personality traits، as a predictive factor on the unsafe acts was surveyed in a construction project of a car manufacturing company. In this study، personality traits and unsafe behavior rates were determined using NEO-Five Factor Inventory (NEO-FFI) and safety behavior sampling (SBS) technique. The Spearman correlation coefficient was used. To analyze the acquired results، the total population of the project was 243 people. The results showed that 31. 7% of workers’ behaviors were unsafe behaviors. The correlation between unsafe behaviors and the neuroticism and extroversion were direct and significant (p<0. 001). Assessment of the personality traits could be used as a predictive tool to identify employees with higher rates of unsafe behaviors and helps planning to reduce the accident rates.

One of the most important threats for employees working in chemical industries is exposing to the chemical materials. Lack of precaution and control regulations during working with chemicals can have irreparable consequences. So، in order to achieve an effective control program، it is necessary to have an appropriate assessment of the procedures involving exposure to the chemicals. William-fine method can provide an acceptable insight into hazard risk rate. In this study، a combination of AHP and William-fine adopted to achieve a model for chemicals exposure risk assessment in oil and gas industry. The numbers were extracted from questionnaire، and then، they weighted entered to assessment the model. Finally، they were presented quantitatively with protection layer. Result and The results revealed that the quantitative amount of consequence، probability and exposure was 83. 2، 8. 45، and 2. 2، respectively. Generally، the chemical exposure risk number was 1546 which shows that reforming plans are in highly priorities from an economical point of view. William-fine method has the benefit of an accurate chemical exposure by combination of effect severity، exposure probability and detriment rate، and also minimization of personal judgments during the assessment.