فهرست مطالب farshad banouei

Today, bladder cancer causes a lot of mortality and morbidity and imposes huge costs directly and indirectly on society. With the expansion of new treatment methods and the changes these methods bring to the quality of life and longevity of patients, physical disorders are also increasing among these patients.

In the present study, 487 patients with bladder cancer were assigned to three groups of non-surgical treatment, orthotopic, and conduit surgery techniques, and each group of patients was examined 1-2 months before the start of treatment and 6-8 months after that using the Hospital Anxiety and Depression Scale (HADS) questionnaire.

In this study, the prevalence of mood disorders in the conduit surgery group increased from 55.07% before surgery to 79.12% after surgery, which was statistically significant (P=0.003). Nonetheless, there was no significant increase in the other two groups. In the investigation of anxiety disorders, the prevalence of anxiety disorders increased from 22.79% to 43.68% in the conduit surgery group, which was statistically significant (P=0.0016).

According to the nature of the disease, before starting the treatment of these patients, by conducting psychological counseling and providing sufficient information to the patients, the necessary preparation should be created in the patients to accept the side effects caused by the treatment and reduce its psychological burden, which greatly improves the treatment results.

Prostate cancer is currently the second most common cancer among men worldwide. Given the prevalence of this disease and the costs imposed on society for its diagnosis and treatment, awareness of diagnostic and therapeutic modalities, and factors influencing their outcomes is of particular importance.

This prospective study aimed to investigate the diagnostic accuracy of 99mTc- PSMA scan and 99mTc-MDP Bone scan in 40 patients with prostate cancer and bone metastases. The study was conducted between 2020 and 2023, and the results were compared based on the tissue differentiation of cancerous tissues.

Data analysis revealed that the diagnostic accuracy of 99mTc- PSMA scan and 99mTc-MDP Bone scan for grade groups 1-5 ranged from 95.4% to 100% and 95.4% to 100%, respectively. However, none of the results were statistically significant. Specifically, the 99mTc- PSMA scan demonstrated diagnostic accuracy percentages of 100%, 98.7%, 96.1%, 96.6%, and 95.4%, respectively, for grade groups 1 to 5. Similarly, the diagnostic accuracy of 99mTc-MDP Bone scan for grade groups 1 to 5 was 100%, 96.3%, 98.7%, 96.6%, and 95.4%, respectively.

The statistical analysis of the data suggests that tissue differentiation of prostate cancer does not impact the diagnostic accuracy of 99mTc- PSMA scan and 99mTc-MDP Bone scan. Moreover, the Gleason score of tissue samples did not affect the differentiation of cancerous tissues by the scans. Therefore, the findings suggest that 99mTc- PSMA scan and 99mTc-MDP Bone scan can provide accurate diagnostic results for prostate cancer patients with bone metastases, regardless of the tissue differentiation or Gleason score.