fateme majidi

In a system biology-based study, we previously reported that IL-6 and IL6R -specific m-RNA levels were elevated in leukocytes of patients with Rheumatoid arthritis (RA). Here, the association of toll-like receptor4 (TLR4) rs 141534085 and cytochrome P450 family 51 subfamily A member 1(CYP51A1) rs6 with tumor necrosis factor-α (TNF- α), rheumatoid factor (RF)- and Anti- cyclic citrullinated peptide (anti-CCP) antibody -positivity was investigated in almost the same subjects. Forty-six patients and 48 normal subjects were recruited in this study. The blood leucocytes TLR4 rs 141534085 and CYP51A1 rs6 -comprising DNA sequences were amplified by using tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique and the PCR products were checked by Sanger DNA sequencing method. ELISA method was used to determine plasma levels of TNF- α, anti-CCP antibody and RF positivity of plasma was evaluated through a latex agglutination test. The TNF- α level was significantly higher in the patient group than control subjects (p= 0.001). Moreover, we were not able to find any correlation between TNF-α levels and RF as well as anti-CCP antibodies when we used the K2/ Fisher's exact test and Pearson test respectively. Our DNA sequencing data revealed the following new mutations in TLR4 rs141534085 comprising regions: A>T in position 1050, T>A in position 1052, and C>A in position 1054; and for CYP51A1 rs6 encompassing region, the new mutations were; G>A in position 21680, the T nucleotide was inserted in position 21762 and the G nucleotide was inserted in position 21763, G>T in position 21764. The data of this study showed that both TLR4 rs141534085 and CYP51A1 rs6 related DNA regions should be considered as hotspot areas in RA pathogenicity. Moreover, these data indicated that, TNF- α did not alter the production of anti-CCP and RF pathogenic antibodies   in patients with long-term RA.

This study examines and compares the issues of ideology in the lexical, syntactic, and rhetorical layers of the poems composed by Simin Behbahani (1927-2014), an Iranian poetess, and Golrokhsar Safiava (b. 1947), a Tajik poetess. Both, poems are analyzed with regard to the dominant ideology of their time. In Behbahani's poem, the feminist ideology is more explicit and is characterized by modern words, feminine language and new perspective. Safiava's poem, however, does not express feminine feelings explicitly; indeed, feminine themes find their way into her poetry but are not dominant. Her poetry is mostly identified with nationalism. The ideology of both poets is revealed through all the three layers of language (lexical, syntactic and rhetorical). The symbols in Behbahani's poetry cover the feminist discourse, while the symbols in Safiava's poetry are national-patriotic with the color of war and defense. Ideologies are reflected in the linguistic layers of both, but Safiava is more explicit in this case. Her ideology is more distinguished in the lexical layer. In Behbahani's poem, the ideology is mainly of syntactic and rhetorical significance and gives the poem artistic individuality. From this point of view, Safiava's is claimed to have remained Clichéd.

Rheumatoid arthritis(RA) is a complex and chronic disease of joint inflammation. Environmental factors that are important in genetically predisposed people are involved in the occurrence of the disease and its progress. This disease has a lot to related to genetics, including human class 2 antigens. In various studies, this relation is about 60%. This relationship is more positive in people with Anti-citrullinated protein antibodies (ACPA) than negative ones. The aim of this study is to investigate the relationship between cytokines and soluble proteins in the body of a patient with Rheumatoid arthritis before symptoms appear.

In this research, analysis with Enrichr, WebGestalt, and GeneMANIA was used to find genes related to the disease. In order to check the amount of cytokines predicted, ELISA and Real time RT-PCR methods were applied.

By examining the System Biology methods, the candidate genes included IL-6R, IL-6 and IL-23A. The samples were taken from 46 RA patients referred to the rheumatology department of the Babol hospital, and a significant decrease (Pv=0.1255) of IL-6 was observed in patients undergoing treatment and a significant increase (Pv=0.4414) in the amount of this cytokine receptor in the serum compared to healthy individuals. While the expression of IL6 and IL6R genes increased in the patient group compared to the healthy group.

Cytokine IL-6 as an inflammatory cytokine in treated patients decreased in serum and showed a significant increase in RNA level.

This article examines the reflection of ʿAṭāMalik Juvaynī’s critical stance on the Mongols and the residents of cities of Khurāsān in Tārīkh Jahāngushā. In doing so, we will first put forward a critical report of the several previous studies related to this topic. After providing examples of textual modality signs sacralizing the Mongols, we will explore how Juvaynī corresponds the Mongol invasion on Khurāsān with some ʾĀyahs and Ḥadīths as a method for sacralizing and legitimizing Genghis and his successors. We will illustrate how these religious and persuasive tools, as well as some other textual components, add to the coherence of Juvaynī’s account and give it a marked bias, based on which Juvaynī’s critical stance on Mongols and the residents of Khurāsān can be explored.