fatemeh rahbar

Asthma is a prevalent disease that affects oral health-related quality of life (OHQoL). There is no study on this issue in Iran, so this study investigated the OHQoL in asthmatic patients.

In this descriptive analytical study, 54 asthmatic patients in Sari Tuba Medical Center were examined. They were selected by convenience sampling. The Oral Health Impact Profile-14 (OHIP-14) was administered and Ramfjord teeth were selected to examine the OHI-S index. Data analysis was done applying descriptive statistics and Kolmogorov Smirnov test in SPSS V25.

The mean age of patients was 38.05±12.57 and 75.9% were women. The mean scores for OHIP-14 and OHI-S were 2.40±1.14. The highest score in the quality of life questionnaire was related to physical discomfort (1.17±0.96). There were no significant differences between gender, DI, and CI in OHQoL (P=0.893), and OHI-S and OHQoL (P=0.690).

In current study, no relationship was found between oral health of asthma patients and the OHQoL, but dentists are recommended to consider the impact of oral problems on patients' quality of life in addition to professional measures.

Type 2 diabetes (T2D) is chronic health caused by the interaction between genetic and environmental factors that results in high blood glucose. The evidence-based guidelines for diabetes management are mainly based on lifestyle changes, control of risk factors, and the management of blood glucose levels. Although numerous antidiabetic agents have been developed over time, T2D treatment should be based on the patient's genomic characteristics. In the present study, we review genetic variations that may be responsible for a common therapeutic response in diabetes.

The treatment of T2D is discussed in the perspective of a pharmacogenomic approach by searching for related studies on PubMed, Scopus, Web of Sciences (WoS), and Scholar databases.

Among the antidiabetic drugs used in T2D treatment, the association of six drugs, including metformin, sulfonylurea, meglitinide, DPP4 inhibitors, SGLT-2 inhibitors, and Thiazolidinedione's with commonly related genes in responding to the drugs was found among the studies.

Pharmacogenomics studies investigate the role of genomic variations in drug efficacy and toxicity. The finding of genetic factors that modulate the glycemic response may provide a new way to T2D treatment and may ultimately advance the development of precision medicine therapy. Early diagnosis and appropriate treatment can reduce the severity of diabetes and its related complications.

Hypothermia is likely to cause enormous dangers for patients undergoing cesarean section.

This study aims to comparison between the effect of using two different temperatures of IV fluids (37.5°C versus 21-22°C) in body temperature drop and the post-operative pain.

This experimental study was double-blind clinical trial, conducted in 2017 (April, 2017 to January, 2018). The method of sampling was simple random sampling. The randomly selected mothers, undergoing cesarean section, were assigned into two groups of equal number (the hexagonal blocks of A and B) in this clinical trial. The experimental and control group participants received IV fluid at the operation room temperature (25°C) and the IV fluid of 37.5°C, respectively. The core intraoperative body temperature was measured by Microlife Infrared Tympanic-IR100 thermometer. Severity of the experimental and control group patients’ post-operative pain was also measured and compared for 24 hours (since when the patients were discharged from the recovery ward) by the VAS (0-10).

A total of 80 patients underwent this study. The demographic information of the two group members showed no difference of significance (p>0.05). The average intraoperative body temperature of the experimental group participants was higher in the level (p=0.001) of significance than that of the control group members. There was no difference of significance (p=0.41) between the mean severity of pain of both groups’ participants in the first 24 hours.

The intraoperative IV fluid warming seems not to have any tranquilizing effect in the post-surgery pain.

By development of bacterial drug-resistance to traditional antibacterial drugs and fungal infections, the need to design, synthesis, and use of new and effective antibacterial and antifungal drugs is increased. Quinazolinone derivatives are heterocyclic compounds with nitrogen atoms that have pharmacological properties such as anti-bacterial, anti-tumor, anti-inflammatory and antifungal properties. The aim of this study was to synthesize of new derivatives of dihydroquinazolinone and study of their anti-bacterial and antifungal properties. This research is an experimental work in which four dihydroquinazolinone derivatives were synthesized, by a new environmental-safe method and identified by various spectroscopic methods. Antibacterial activities of these derivatives were investigated against Escherichia coli gram-negative, and bacillus subtilis gram-positive in comparesion with amikacin. Antifungal activities of these derivatives were investigated against Aspergillus niger fungus and compared with ketoconazole. Both of antifungal and antibacterial activities of these synthetic compounds derivatives was checked by disk diffusion method with measuring the zone inhibition. All synthetic dihydroquinazolinones that were synthesized in high yields and purity, showed good antibacterial and antifungal properties. The compound 1d 2-phenyl-2,3-dihydroquinazolin-4(1H)-one derivative of these compounds showed more antimicrobial activities and antifungal comparable with the Amikacin and Ketoconazole standard antibacterial and antifungal drugs. Synthetic dihydroquinazolinone derivatives in this work have good antifungal and antibacterial activities. The higher antifungal and antibacterial activity of 2-phenyl-2,3-dihydroquinazolin-4(1H)-one derivative can be related to more hydrophobicity of the phenyl group as a substitution in position 2.

The aim of this study is the comparison and evaluation of oil extraction of Damavand walnut by the two methods of solvent and ultrasound in various conditions of sonication duration and power. In this study, Damavand walnut samples were subjected to hexane solvent and ultrasound extraction processes for different sonication duration (10, 20, 30 and 40 minutes) and powers (600, 800 and 1000 watts).Then, assessment tests including acid value, peroxide value, sensory evaluation, moisture content ,volatiles and sediment percent were conducted on the oil treatments. The results indicated that in ultrasound method, the treatment subjected to 1000 watts for 10 minutes had the highest sensory quality. Also, among solvent-extracted treated samples, the oil treated by 1000watts for 10 minutes was the best treatment in terms of sensory characteristics. Chemical tests results also showed that walnut oil samples extracted by ultrasound had a lower peroxide and acid value than those extracted by solvent method. Sensory evaluation results showed that the flavor, pungency and odor of the walnut oil samples extracted by ultrasound method were significantly increased compared to the treatments of solvent method. The overall acceptability of the ultrasound method treatments gained higher score than those of solvent extraction method (P