fatemeh saki

In this research, the Ag/ZnO/SBA-16 was synthesized and used as loading and release of phenobarbital drug. To identify and characterize the properties of Ag/ZnO/SBA-16 nanostructure, several identification methods such as XRD, FTIR, BET, EDX, SEM, and TEM were used. The influence of various parameters was investigated using the RSM methodology, by experimental design (DOE) software. Drug release in three different environments at 37 ℃ including aqueous, acidic, and alkaline was studied. The isotherm and kinetic studies showed that the drug loading process follows the Freundlich isotherm and the Higuchi kinetics model. The thermodynamic study also showed that drug loading on Ag/ZnO/SBA-16 nanocomposite is an exothermic and spontaneous process at low temperatures.

Designing and manufacturing controlled drug release systems can be highly beneficial in improving drug treatment methods. The aim of this study is to synthesize SBA-16 nanosilica and evaluate its use as a drug carrier for carbamazepine. Additionally, this research aims to assess the effects of pH, contact time, temperature, initial drug concentration, and adsorbent amount on the performance efficiency of the drug carrier.

In this study, carbamazepine (obtained from the Food and Drug Organization of Iran), double-distilled water, 1-butanol, hydrochloric acid, pluronic copolymer F127, tetraethyl orthosilicate, and sodium hydroxide were used. All chemicals were sourced from Sigma-Aldrich and Merck. A dialysis bag manufactured by Sigma-Aldrich (14000 MWCO, 99.99% retention) was used for drug release experiments. The equipment used in this research includes a digital scale (EJ 303), pH meter (ST 2100), oven (Memmert), magnetic stirrer (HOTPLATE STIRRER 81), electric furnace (Shimaz), FT-IR device (Magna-IR Spectrometer 550 Nicolet), X-ray diffraction device (STADIP), scanning electron microscope (MIRA3-LMU), UV-Vis spectrophotometer (DB20-UV), and BET analyzer (NanoSORD92). SBA-16 was synthesized using the sol-gel method. XRD, FTIR, SEM, and EDX analyses were employed to identify and characterize the synthesized adsorbent. The effects of pH, adsorbent amount (nanocarrier), drug concentration, temperature, and contact time were evaluated using the response surface method (RSM) with the central composite design (CCD) in the Design of Experiments software (DOE) to determine optimal conditions and maximum drug loading capacity. Langmuir, Freundlich, and Temkin adsorption isotherms were used for adsorption studies, and thermodynamic and kinetic studies were also conducted. The dialysis method was applied for drug release experiments, providing physical separation and allowing easy sampling at different time intervals.

In this study, SBA-16 nanosilica was successfully synthesized, and scanning electron microscope (SEM) images of the SBA-16 surface demonstrated that it had a spherical and homogeneous morphology with particle sizes ranging from 2 to 50 nm. Additionally, the XRD spectrum showed that SBA-16 had a regular structure. Experiment design was used to investigate the effects of key parameters. After conducting the tests, the results were input into the software to generate the best model for evaluating and describing the data. Of the four models (linear, interaction, quadratic, and cubic), the software proposed the quadratic model as the most consistent with the responses. According to the software output, the nanocarrier was able to adsorb 99.87% of carbamazepine under optimal conditions (pH=2, initial drug concentration=20 ppm, drug carrier amount=0.05 g, temperature = 30°C, and contact time=12 minutes). The adsorption data fit the Langmuir isotherm most closely (R²=0.9996). Thermodynamic studies revealed that the adsorption process is spontaneous, exothermic, and physical, following first-order kinetics. The drug release data corresponded with the theoretical kinetic model presented by Zeng et al. (2012) for drug release from mesoporous silica nanoparticles, which assumes an initial burst release in the early hours followed by a slow and steady release.

The nanocarrier introduced in this research is a water-insoluble, non-toxic, and highly effective adsorbent for loading the drug carbamazepine. The results demonstrated that, under optimal conditions, the drug loading efficiency reached 99.87%. Additionally, the study showed controlled drug release. The adsorption process followed the Langmuir isotherm with a regression coefficient of 0.9991, while drug release followed the first-order kinetic model with a regression coefficient of 0.9996. Thermodynamic results indicated that the drug loading process is exothermic and spontaneous

In this work, nanomesopose SBA-16 was prepared from reed plant stem by green method and used to remove Phenolphthalein pollutant. The effect of different parameters (pH, initial concentration of phenolphthalein, amount of SBA-16 adsorbent, temperature and contact time) on the amount of phenolphthalein absorption by the prepared adsorbent was investigated with the help of experiment design software. The results of the predicted experiments showed that the highest absorption of phenolphthalein was in the conditions of pH=4.01, temperature 44°C, contact time 20 min, initial concentration of adsorbent 13 mg/L and amount of adsorbent 0.05 g. can be seen. In optimal conditions, the prediction of the software was 100% removal of phenolphthalein from the water environment, which actually achieved a removal of 99.46%. Considering the high potential of nanomesopore SBA-16 in removing phenolphthalein pigment, it can be considered as a suitable candidate for removing colored pollutants and treating wastewater from textile factories.

Due to the presence of industrial pollutants in water sources, it is necessary to treat wastewater, especially colored wastewater. This study aims to treat wastewater containing methyl orange dye using nano mesopore SBA-16.

In this study, the effect of different parameters (pH, concentration of methyl orange, amount of adsorbent, temperature, and contact time) on the absorption of methyl orange by nanocomposite prepared with the help of Design of Experiment 7 software and Response Surface Method (RSM) was investigated.

The maximum amount of pollutant removal by the adsorbent was obtained under optimal conditions of pH = 4.07, temperature 50 °C, contact time 35 minutes, initial concentration of adsorbent 10 mg/L, and amount of adsorbent 0.04 g. Also, the findings showed that the absorption behavior is most consistent with the Langmuir isotherm and the absorption process is exothermic and spontaneous at low temperatures.

In optimal conditions, the SBA-16 adsorbent was able to remove 98.60 % of methyl orange from the aqueous solution and the maximum adsorption capacity (qmax) for the removal of methyl orange pollutant was 37.73 mg/g. Considering the high potential of nano mesopore SBA-16 in removing methyl orange pigment, it can be considered a suitable candidate for removing colored pollutants and treating wastewater from textile factories.

This research was conducted with the aim of "exploring teaching methods in teaching social studies" using the library method. The results showed that the information and abilities of individuals are different, so teaching methods should be used that take into account the individual differences of students. In the meantime, among the school curricula, the "Social Studies" curriculum, according to the structure and concepts of the field, provides rich and abundant opportunities for the development of the required tendencies and skills. To this end, teachers are able to use a variety of methods and provide learning opportunities. They should be able to use learning units with an emphasis on problem-solving skills and environmental capacities of learners in different ways and using Design and develop new methods. They should also have the skills to analyze the curriculum and adapt it to the needs of learners and be able to design effective learning opportunities and help students with a proper knowledge of the social studies curriculum. To gain a basic understanding of scientific concepts, to ask questions, to explore, to argue, to collaborate, to share knowledge, to express opinions, to present content and subject matter in a way that Understand different.

In the fields of insight recognition, the significances are applied often differently, so despitehaving the same structure and domain in the matter, their coincidence's load varies in differentaspects. Geomorphologic's balance is one of the examples. The meaning of balance is appliedin all evolution aspects of Dayvis, in the field of systematic perception'sdistrict(ramesht1381p77) and also in the Qoran's interpretations. the Dayvis 's point of viewtime would encounter evolutions orgradually depletions, in other words they haveunreturnable changes in a way that this meaning has its origin in antropy's backgrounds andpositive feedbacks. but undoubtedly the balances meaning in dayvis's opinion differs with theqoran's systematic point of view.(chapters:naml,verse88,shams,verse6,meraj,verse9,alqare,verse5 and many others)thatexpresses the evolution, regularity, permanency and balance in the phenomenons. but with thegylbert's that the forms and processes could be related to negative feedbacks that thechangings are with different speeds and cause surfaces forms proportionaly vary with them.therefore the earth's forms are dependant to a situation which the forms that change in ashorter time. in this editorial is tried to analyze the conflicts and the similarities through thebasis of library studies. the issue will help to achieve a better comprehension from themeanings by encountering different views of balance in Geomorphology and also emphasiseson the importance of it's significances load, and the contrasts in different views.

Aspirin is a non steroidal medicine that effects on prostaglandin، follicles، ovulation and corpus luteum. The aim of this study was to evaluate the effect of low (7. 5 mg/kg) dose of Aspirin on the ovarian tissue during implantation period. Females NMRI mice 6-8 weeks old were divided into control and experimental groups. These groups were rendered pseudopregnant then experimental group injected with low dose of Aspirin until 4. 5th day. The mice were scarified with cervical dislocation and then the samples were obtained from the ovary in each group. Then ovarian weight and volume balance were measured and paper section stained with H&E method. Our results showed that weight of ovary in control group was 3. 1±0. 077g and in experimental group was 3. 5±0. 24g (p<0. 05). Volume of ovary in control group was 8. 70±0. 19 mm3، and in experimental group was 9. 20±0. 17 mm3 (p<0. 05). Number of corpus luteum in control group was 6. 2±0. 15، and in experimental group was 12. 21±0. 15 (p<0. 05). In experimental group vascularity of ovary had increased in comparison with control group. The low dose of Aspirin (7. 5mg/kg) increased the rate of corpus luteum and vascularity of ovary. Low dose of aspirin had positive effect on pregnancy during implantation period