فهرست مطالب fereshteh ensani

Ovarian epithelial type carcinomas of testis are an extremely rare group of tumors, a few cases of which having been reported. We present the case of a 67-year-old man, presented with testicular mass and inflation, who underwent radical orchiectomy and pathological and immunohistochemical assessments revealed serous papillary carcinoma of ovarian epithelial type tumor of testis.

Seventy-five percent of salivary gland tumors occur in parotid tumors. These tumors are mainly (75% to 85%) benign and around 25% turn out to be malignant. The most common cases of malignancy are mucoepidermoid carcinoma and adenoid cystic carcinoma (they totally represent half of the malignant tumors). Acinic cell carcinoma (ACC) is not of high incidence and is often seen in major salivary glands, particularly parotid gland. ACC makes up for 1-3% of salivary gland tumors and 3% of total parotid tumors. It is a low-grade malignant tumor with metastatic and invasive ability. Advanced stage, painful and fixed tumor, desmoplasia, anaplasia and differential character of the tumor, high mitosis, and necrosis, and nerve invasion, incomplete removal of the tumor, large size, and invasion to the deeper lobe of parotid worsen the prognosis of this tumor. We present a case report of a 52-year-old man with ACC metastasis to superior left humerus 15 years after surgery.

Since most patients with relapsing-remitting multiple sclerosis (RRMS) are women, the present study aimed to determine whether treatment of patients with MS by cytotoxic agents is associated with an increased risk of cervical dysplasia. Cancer screening is often neglected in the chronic diseases such as MS, so more attention in this field was needed. Decreasing morbidity and mortality due to cervical cancer is the most important goal of screening in female MS patients especially in child bearing age. Thus, it can be said that this is the first study which investigated this important issue.
A total of 129 individuals participated in this cohort study. They were assigned into 3 groups including 43 patients with MS who were treated with cytotoxic drugs, 43 patients with MS on immunomodulators, and 43 normal healthy controls. Pap smears were performed following standard methods and the results obtained from the three groups were compared by statistical analysis. Demographic data, Expanded Disability Status Scale (EDSS), and Pap smear changes were analyzed by SPSS software.
The most commonly detected abnormality in all examined patients and healthy controls was inflammation. Five patients with MS who were treated with cytotoxic agents revealed benign cellular changes (BCC) in their Pap smear that were statistically significant in comparison with other groups (P = 0.03). Patients who took Mitoxantrone presented BCC more than other groups [Odds ratio (OR) = 9.44, 95% confidence interval (CI): 1.46-60.70]. There was no significant difference between mean duration of MS diagnosis (P = 0.12), mean duration of previous MS treatments (P = 0.25), and mean duration of current MS treatments (P = 0.21) in patients with BCC compared to normal healthy controls or inflammatory change.
According to the results of present study, BCC is more frequently observed in patients with MS who were treated with cytotoxic agents with immunosuppressive effect. Since BCC is a ‘premalignant condition’, the authors suggest that mandatory annual Pap smear should be performed for patients with MS who are treated with cytotoxic agents irrespective of their age in order to detect early signs of malignancy.

Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented.
The study included 100 formalin fixed, paraffin-embedded specimens of invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran, from 2011 to 2014. Immunohistochemistry was applied to detect ER, PR, and Her-2.
The current study findings indicated a significant correlation of 90% between CNB and SE specimens for ER expression. The correlation between CNB and SE specimens was estimated as 81% and 97.3% for PR and Her-2, respectively.
CNB can be performed confidently to determine ER and Her-2. For PR, results obtained from CNB should be considered.

We present here a 32-year-old male with advanced lately diagnosed, right sided retroperitoneal mass, which had been already treated due to progressive muco- cutaneous lesions clinically consistent with psoriasis, during recent four years. The advanced retroperitoneal mass resected surgically and reported as hyaline-vascular castleman disease with a dense focus of coarse calcification, on histopathology. Association of psoriasis and castlman disease is discussed in this case report. © 2017 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2017;55(4):276-278.

Primary cardiac sarcomas are very rare and there is no consensus on management. Clinical presentation is usually late. Despite newer diagnostic technology, prognosis remains dismal. We report a case of right atrial sarcoma in a 28-year-old man who presented with acute cardiac tamponade. Emergency subxiphoid pericardial drainage stabilized the patient's critical condition. The lesion was advanced. Therefore, we only performed a suboptimal surgical resection. Despite planning for radiation, the patient's status deteriorated. Only palliative measures continued during the next four months before his death due to disseminated metastasis and progressive cardiopulmonary failure.

Prostate cancer is the second most common malignancy after skin cancer, and second leading cause of cancer death in western countries. However its incidence and mortality is lower among Iranian population. At the time of diagnosis, about 30% of patient have regional or distant metastasis. Orbital metastasis is uncommon in adult and represents only 2-9% of orbital tumors. We present a case of prostate adenocarcinoma with metastasis to the left orbital cavity from the Cancer Institute of Iran. The patient was a 62-years old man, with known adenocarcinoma of prostate from 2011 was referred to the Cancer Institute of Iran in March 2013. He was suffering from progressive left eye vision loss, proptosis, a growing mass in the left orbit, diplopia, headache, and generalized bone pain.Core needle biopsy from the mass revealed moderately differentiated adenocarcinoma. The patient was discussed at the tumor board on March 2013. The board recommended palliative radiation to the orbit, effective pain control regimen, and other necessary measures. Due to poor general condition, orbital radiotherapy was not possible, but he received other palliative measures. The disease was progressed and patients passed away within 2 months. Orbital metastasis of prostate cancer is very rare. Prognosis is usually poor and the treatment depends on the level of extension and general condition of the patients.

A 38 years old male worker presented with an advanced left side retroperitoneal mass, with metastatic involvement of 11th Thoracic Vertebra (T11) and resultant paraparesia and paresthesia. The histopathologic examination and immunohistochemical analysis confirmed the diagnosis of paraganglioma. Decompression laminectomy and fixation of involved vertebra resulted to considerable symptomatic relief. Due to unresectability at presentation, chemotherapy with palliative intent performed, and resulted to mild response. Palliative debulking performed after chemotherapy and resulted to better quality of patient's life during next 8 months. Remaining mass at pelvic area increased in size and patient received (131)I-MIBG therapy, 8 months post-operatively. A second debulking surgery, as well as other palliative measures will be considered for future.

Considering molecular target therapy concept in the treatment of oral squamous cell carcinoma (OSCC), many attempts have been performed to introduce an effective molecular marker during recent years. Several investigations have emphasized on the role of CD44 in variouscancers and few studies have mentioned CD24 and CD74. The purpose of this study was to investigate the relationship between CD44, CD24 and CD74 expressions and several clinical or histopathological factors in OSCC patients. In our analytical cross-sectional study, forty primary OSCC specimens were immunohistochemically stained for CD44, CD24, and CD74 proteins. Then, the relationship between their expressions and age, sex, lymph node metastasis, and histopathologic grading was statistically analyzed using Mann-Whitney nonparametric and t-test. Furthermore, P < 0. was considered as signifi cant. CD44 and CD74 proteins were signifi cantly over-expressed in OSCC patients with high grade (P = 0.001 and P = 0.001) as compared to those with low grade. Furthermore, CD74 immunoreactivity showed signifi cantly higher expression in patients with lower age (P = 0.039). Considering lymph node metastasis, we observed signifi cant overexpression of CD74 in patients with no lymph node involvement (P = 0.033). Our observations support the signifi cant role of membranous CD44 protein in progression of OSCC and also introduce CD74 protein as a probable interfering factor in different aspects of OSCC.

Synovial sarcoma (SS) is a relatively common soft tissue tumor but only 6%–7% of cases are diagnosed in the head and neck region. It typically occurs in young adults and is slightly more common in males. The most common sites in the head and neck region are hypopharynx and parapharyngeal spaces. However, SS can also occur in tonsils, tongue, and orofacial soft tissues. It is not difficult to diagnose SS microscopically with its classic biphasic appearance, but the diagnosis of monophasic forms is more challenging especially in unusual locations. In this article, we report a rare case of monophasic SS of the mandible. The clinical, histopathological, and immunohistochemical features are discussed and compared with previously reported cases in the literature. To our knowledge, only six primary involvements have been reported in the jaws. Therefore, our case represents the seventh reported case of SS in the area.