فهرست مطالب gh bayani

Jaundice is considered as a common clinical condition during. Prevention of severe hyperbilirubinemia is safer and easier than current therapies, like phototherapy or blood exchange. In some animal and human studies, zinc was found effective in reducing jaundice. In this study we evaluated the effect of oral zinc sulfate on serum bilirubin of newborns under 1800 gram.
This randomized, clinical trial was performed on preterm ( Among 66 eligible newborns 32 were placed in group A and 34 in group B. The mean serum bilirubin in group A and B was defined as 7.7± 2 and 8.7± 2, in the third day (P = 0.053) and 6± 2 vs 7.6± 2 (P=0.012) in the seventh day, respectively and showed significant difference between two groups. Duration of phototherapy was recorded longer among placebo group (108 vs 84 hours)
The current study showed that prophylactic administration of 10 mg zinc sulfate in preterm babies may reduce serum bilirubin. Weight loss at the end of first week of life was less among newborns received zinc sulfate. Less phototherapy duration was reported in the zinc group in comparison with the placebo group. No acute adverse effects were reported in the zinc group.

Jaundice is a common clinical aspect during infancy which affects term (60%) and preterm (80%) newborns in the first week of life. One of the most common reasons is glucose- 6- phosphate dehydrogenase (G6PD) deficiency that might increase the risk of severe hyperbilirubinemia and kernicterus. The aim of this study was to determine prevalence rate of enzyme deficiency in newborns with jaundice in North Khorasan. We also compared clinical and paraclinical values and complications among G6PD- deficient and normal G6PD infants who were admitted in the hospital due to jaundice. This analytic descriptive study was performed on files of newborns with jaundice. Information of babies who admitted due to jaundice such as perinatal history, clinical and laboratory findings were collected and recorded. Data was compared between two groups of normal G6PD and G6PD deficient- neonates. Statistical analysis was carried out using SPSS 17 statistical package. Among 754 admitted infants with jaundice, we found 24(3.2%) babies with G6PD deficiency. We did not find any significant differences between two groups for variables like birth weight, weight on admission, total serum bilirubin, hematocrit, coombs, hospitalization period whereas a significant statistical difference for reticulocyte was recorded. We did not find any relation between G6PD deficiency and number of blood exchange performing. G6PD deficiency is a common enzyme defect among newborns with hyperbilirubinemia (3.2%) in North Khorasan, Iran and may cause severe hyperbilirubinemia and kernicterus. There was significant difference between two groups for reticulocyte count. By screening all infants in high prevalence places and on-time treatment we can prevent further complications of G6PD deficiency disorder.