فهرست مطالب gholamhossein omrani

Metabolic syndrome (MES) consists of central obesity, hypertension, reduced high density lipoprotein (HDL), elevated serum triglycerides and high Fasting blood sugar (FBS). They are susceptible to cardio-vascular disease, and insulin resistance. The goal of present research was to assess any relation between the composition of the body in Type 1 Diabetes Mellitus (T1DM) children and having components of metabolic syndrome.
This cross sectional study included all T1DM children who were referred to the pediatric clinic of diabetes, affiliated to the Shiraz University of Medical Sciences, Iran during Jul 2013 to Aug 2014. Anthropometric data, blood pressure, fasting blood glucose, lipids and body mass indices like android and gynoid fat mass was done by one physician with standard scale and techniques. The obtained data were analyzed using SPSS-18.
Overall 87cases with definite diagnosis of T1DM were admitted in this duration (2013-2014).There was a positive correlation appeared between hypertriglyceridemia and Android fat mass (r=0.1 and P =0.046). Otherwise, there wasn’t any relation between body composition criteria and the reduced HDL level, high blood pressure, Abdominal obesity and elevated FBS (P>0.05) .
It was revealed that hypertriglyceridemia was associated with Android fat mass. However, more pathophysiological research is needed to reveal the association of MES components and body-composition in T1DM children.

We performed a prospective study to evaluate the effects of pelvic irradiation on FSH, LH and testosterone levels in male patients with rectal adenocarcinoma. Our aim was to compare the level of male sex hormones in peripheral blood serum before and after pelvic irradiation. The eligible participants were 40 men with rectal adenocarcinoma who underwent pelvic radiotherapy as part of their treatment for primary tumor, either before or after surgery. All patients received a 50-Gy radiation dose to the pelvis, 2 Gy per fraction, five days per week. Blood was sampled three times during the study: once before radiation, at the end of the radiation course and 4 to 6 weeks after radiotherapy. Median age of the patients was 58 years (range 18-82). The mean testis dose of radiation per fraction in all 40 patients was 16.3 cGy with a standard deviation of 15.22 (range 5.5-64.8). Serum levels of FSH revealed a significant increase from 7.5 ± 1.7 IU/L (before treatment) to 20.9 ± 17.8 IU/L [end of radiotherapy (P<0.001)] and 24.1 ± 20.5 IU/L [4 to 6 weeks after radiotherapy (P<0.001)]. Serum LH levels were significantly elevated from 8.04 ± 1.2 IU/L before radiation to 11.6 ± 11.5 IU/L at the end of radiotherapy (P<0.001) and 12.5 ± 9.9 IU/L 4 to 6 weeks after the final course of radiotherapy (P<0.001). There was a decrease in serum testosterone from 5.3±2.1 ng/mL before radiation to 4.2 ± 1.9 ng/mL at the end of radiotherapy (P=0.004) and 4.5 ± 2 ng/mL 4 to 6 weeks after radiotherapy (P=0.035). No significant correlation was seen between age and differences in sex hormones (LH, P=0.605; FSH, P=0.380; testosterone, P=0.161). There was a significant change in serum levels of male sex hormones after pelvic irradiation for rectal cancer (total dose, 50 Gy) that indicates considerable testicular damage under these circumstances. Thus, it seems logical to use techniques that reduce the radiation dose to the testicles and to consider the benefits of hormonereplacement therapy as well as semen cryopreservation for high-risk patients who desirechildren in the future.

According to Iran’s folk medicine, camphor, a crystalline ketone obtained from essential oils of Cinnamomum camphora, has both sexual behavior attenuating and enhancing properties. This study examined the effects of camphor on sexual behavior in male rats. Twenty four sexually mature male Sprague-Dawley rats were randomly divided into 4 groups receiving daily i.p. injections of olive oil as vehicle (2.5 ml/kg) or camphor at 2.5, 12.5 or 50 mg/kg for 7 days. Afterwards, mount latency (ML), mount frequency (MF), intromission latency (IL) and intromission frequency (IF) of male rats in the presence of sexually receptive females rats were recorded. There was no significant difference in MF or IF from control and experimental groups. However, at the 50 mg/kg dose, camphor reduced the ML and IL relative to that of control rats. The finding indicates that at this dose, camphor had sexual desire and sexual performance enhancing properties.

Neuropathy is a common complication of diabetes mellitus. Meticulous neurological examination and electrodiagnosis are valuable tools in early diagnosis of neuropathy and prevention of its sequels. A hundred and three randomly selected diabetic patients were recruited from the endocrine clinic. Mean age of patients was 52.6 ±14 years. 29.4% had type 1 and 70.6% had type 2 diabetes.Medical history was taken from patients and neurological examination was done. Electroneurographic examination included nerve conduction velocity, action potential amplitude, distal latency and H reflex measurements. Neuropathy was found in 79.4% of patients. The prevalence of neuropathy had a direct relation with duration of the disease. The most common complaints were tingling and numbness of extremities (72%) and burning sensation of the feet (36%). The most common physical findings were abnormal ankle jerk (92%), and decreased vibration perception (76%) in feet. Abnormal H reflex(92.5%) and decreased amplitude of action potentials (79%) were the most common electroneurographic findings. There was a strong correlation between clinical and electroneurographic findings. Neuropathy was quite common in diabetic patients. Neurologic examination is, therefore, recommended to prevent unnecessary workups and prevent complications.

Atherosclerotic complications are one the most common causes of death in patients with type 2 diabetes mellitus. Epidemiological data indicate that the consumption of omega-3 unsaturated fatty acids (O3FA) leads to a reduction in cardiovascular disorders. The metabolic effect of this substance in patients with type 2 diabetes is still a matter of debate, however. The aim of this study was to assess the metabolic effect of O3FA in Iranian diabetic patients.
50 diabetic patients (20 men and 30 women; mean age 49±7.3 years) were randomly allocated to either the intervention (diet fish oil containing O3FA) or the control group (diet alone). The lipid and glucose levels, blood pressure, and weight of each patient were measured at the beginning of the study. The duration of the study was 3 months. The aforementioned parameters were re-assessed at the end of the study.
O3FA consumption was associated with a significant reduction in serum triglyceride levels (p O3FA may be recommended for the management of hypertriglyceridaemia.

Atherosclerotic complications are one the most common causes of death in patients with type 2 diabetes mellitus. Epidemiological data indicate that the consumption of omega-3 unsaturated fatty acids (O3FA) leads to a reduction in cardiovascular disorders. The metabolic effect of this substance in patients with type 2 diabetes is still a matter of debate, however. The aim of this study was to assess the metabolic effect of O3FA in Iranian diabetic patients. 50 diabetic patients (20 men and 30 women; mean age 49±7.3 years) were randomly allocated to either the intervention (diet + fish oil containing O3FA) or the control group (diet alone). The lipid and glucose levels, blood pressure, and weight of each patient were measured at the beginning of the study. The duration of the study was 3 months. The aforementioned parameters were re-assessed at the end of the study. O3FA consumption was associated with a significant reduction in serum triglyceride levels (p<0.001). Reductions in weight, fasting blood sugar, and glycosylated haemoglobin were noted in the intervention group but were not statistically significant. No changes occurred in total cholesterol, HDL, and LDL levels. The dosage of oral hypoglycaemic agents was unchanged in both groups throughout the study. O3FA may be recommended for the management of hypertriglyceridaemia.