h. nabavizadeh

Liver function indices and anti-viral immune regulatory markers can both improve graft outcomes, which lead to better post-transplantation management and increase the possibility of surveillance in liver transplant recipients with chronic hepatitis B virus (HBV) infection.
To determine the association between the interferon regulatory factor 1 (IRF1) mRNA levels and liver enzymes in HBV-infected liver transplant recipients with and without experience of rejection.
A total of 46 chronic HBV-infected patients who had undergone liver transplant surgery was divided into 2 groups of recipients “with rejection” and “without rejection.” Blood samples were collected form each patient on days 1, 4, and 7 post-transplantation. A SYBER GREEN real-time PCR was used to evaluate the expression level of IRF1 in liver recipients. Liver enzyme activities were also measured in all patients.
The expression of IRF1 in the patients with rejection was up-regulated at all 3 follow-up days compared with those without rejection. The serum levels of ALT and AST were more than normal levels at 3 follow-up times in both study groups. Significant differences were found in IRF1 gene expression levels and also serum ALT levels between those with and without rejection after 7 days post-transplantation.
The IRF1 expression and serum ALT levels were increased significantly in patient with rejection compared to those without rejection. IRF1, an inflammatory factor, may also intensify induction of inflammatory pathways in engrafted liver and promote liver inflammation and injuries leading to liver enzymes elevation in patients with graft rejection.

Introduction and

Ig E –mediated allergy to protein of natural rubber ‎latex is an important global health problem. Because specific immunity status of ‎children and adolescents with renal failure, possible exposure to other cross-‎reactive allergens specially pollen and trees, their exposure to frequent ‎hemodialysis and use of gloves, catheters and other equipment containing latex, ‎this study was aimed to determine prevalence of latex allergy in children and ‎adolescents under 18 years old who treat with hemodialysis in hospitals of Shiraz ‎University of Medical Sciences -2006.‎

In this descriptive cross-sectional study, reaction of 68 ‎participants to scratch skin test (Prick) with standard latex extract, previous ‎history about sensitivity and their demographic characters were analyzed by ‎SPSS.win 11 software with using descriptive and inferential statistic such as ‎proportion test, independent t-test and Chi-square.‎

Finding showed that one of the seven subjects (14.7%) has positive ‎reaction to latex. Proportion test indicated that this prevalence rate was higher ‎than the normal population sensitivity rate (P =0/001).

With respect to results, researchers suggest that the exact history ‎taking and the necessary latex allergy tests must do in this high risk group to ‎prevent damage and possible side effects. Also, for reduce of sensitivity of latex, ‎we recommend that protein component of the gloves, the catheter and other ‎used equipment containing latex has decreased by Chlorination, Autoclaving ‎and use of Proteolytic enzymes or Nonionic surfactants such as Polyethylene ‎glycol ‎‏.‏