فهرست مطالب hamid reza mohammadi

Cancer occurs in 83% of liver diseases. Other risk factors for liver cancer include viral hepatitis, alcohol consumption, industrial chemicals, and a number of toxins. Another major disease that occurs following liver damage is hepatic encephalopathy. This condition arises primarily due to increased blood ammonia levels. Carvacrol, with antioxidant properties, reduces oxidative stress on the liver. The aim of this study was to investigate the effect of carvacrol on the improvement of hepatic encephalopathy in rats.

In this experimental study, 60 male Wistar rats were randomly divided into six groups of 10 each. Liver damage and induction of oxidative stress were caused in the rats by administering thioacetamide (100 mg/kg/day) intraperitoneally for three consecutive days. Carvacrol was administered by gavage at 25, 50, or 100 mg/kg/day after thioacetamide treatment. We investigated the biomarkers of liver damage in the blood, such as alanine transaminase, lactate dehydrogenase, total protein, and bilirubin. We also assessed the effect of oxidative stress, as the key inducer of hepatic encephalopathy, on the liver by measuring the lipid peroxidation, antioxidants, reactive oxygen species, glutathione reserves, and ammonium levels in the serum and brain.

Thioacetamide significantly increased the biochemical markers in the rat sera, reflecting ammonium release and the development of oxidative stress (P<0.05). Conversely, the various doses of carvacrol significantly reduced the levels of biomarkers that are indicative of liver damage (P<0.05).

The study findings provided experimental evidence in favor of the therapeutic effects of carvacrol and against liver injury induced by thioacetamide, leading to encephalopathy.

As one of the key countries in the Middle East and home to two of the most important cities in the Islamic world, developments in Saudi Arabia inevitably impact the broader Muslim world. However, the nature of political legitimacy, acceptance, and the challenges faced by the government remain uncertain. Moreover, understanding the relationship between the people, religion, and the state in this monarchy is crucial. Approximately 50% of Saudi Arabia's population consists of young people. Managing this segment of society presents a significant political, economic, social, and cultural challenge for the Al Saud regime. If the government fails to control the energy and frustration of these youths, it seems likely that the foundations of the regime could become unstable. This could potentially lead to the rise of social movements in Saudi Arabia. As witnessed during the Arab uprisings of 2011, the possibility of a domino effect in the region exists. Additionally, given the secular behaviors the government is employing to manage this situation, it appears that the relationship between religion and the state in Saudi Arabia is changing. Should this phenomenon continue, the social contract itself may also evolve. Even if social movements emerge in the country, analyzing and predicting their nature from local, national, regional, and even global perspectives is of great importance.

The present research adopts a qualitative methodology with a descriptive-analytical and historical approach. Data collection involved documentary-library research and interviews. The study also utilizes books, academic and research articles, both domestic and international, as well as online resources to answer the research questions. The data analysis strategy is inductive.

The government of Saudi Arabia was established in 1932 based on the ideology of Wahhabism and the Al Saud tribe, and these two pillars have remained the foundation of the state until today. The rise to power of Mohammad bin Salman can be seen as the pinnacle of the liberal movement's ascension against the Wahhabis and the Muslim Brotherhood. With the changes introduced by Mohammad bin Salman in recent years, it appears that Wahhabism and the monarchy may no longer continue. The alteration of this alliance poses a significant threat to the future of the Al Saud regime. Therefore, these changes are being implemented cautiously and gradually. Distancing from religion is a major risk that could lead to challenges for the future of Saudi Arabia. The underlying framework of Saudi Arabia's political and social order is based on Sharia, specifically Wahhabism. This is an inseparable part of the country's character and the foundation of the legitimacy of its political and social order. The Saudi government neither created nor inherited religious institutions. In this country, religious elites and politicians have cooperated for many years to establish and protect the state. This explains the overlap between religious and political discourses and also highlights the reason behind the opposition of religious clerics to certain secular actions taken by the government. The Saudi regime derives its legitimacy from Islam.The king, as the ruler, is responsible for enforcing Islamic laws, and the constitution repeatedly emphasizes the implementation of Islam. Saudi Arabia is known for three things: its unique position in the Middle East, being the world's largest oil exporter, and hosting pilgrims to the Holy Kaaba and the Prophet's Mosque. The religious role remains a high priority for the people. However, with the rise of bin Salman, Wahhabi institutions and movements have become isolated, gradually losing their power, and government policies have leaned towards secularism. Examples of this include the decline of the religious police, changes in the role of women in society, shifts in academic institutions, and the organization of events and festivals where Islamic symbols are absent, such as the Riyadh Season.

Iconography, as a spiritual factor and a force gravitating toward the center, is most prominently represented in Saudi Arabia by religion (Wahhabism), which has solidified the state's current structure. However, the government, through its recent actions, has sought to change its relationship with religion, opting for a different narrative of Wahhabism, which it refers to as "moderate Islam." Given the historical background of the Saudi people and the importance of religion and tradition in this country, this shift will likely lead to centrifugal tendencies among the citizens. Initially, it will create dissatisfaction among the people, and secondly, it will integrate citizens into the global context. This will result in a form of dislocation that has not been experienced in Saudi Arabia until now. With the new policies adopted by the Al Saud regime, religion's ability to serve as a unifying force is weakened, turning it into a centrifugal factor. In reality, the iconographic factor has transformed into circulation. Now, with the new religious policies, the government intends to no longer accept Wahhabism as the source of its legitimacy and instead seeks to adopt moderate Islam as its legitimacy factor. Until now, Saudi Arabia has positioned itself as the standard-bearer of Islam, as evidenced by the first article of the country's constitution. Therefore, neither bin Salman nor any other ruler in this country can govern outside the framework of Islamic laws or norms. Bin Salman is aware that he cannot change the country's constitution, or if such a change were to occur, it would come at a high cost with an uncertain future. Therefore, he is seeking to construct a new narrative of Islam, called moderate Islam, to govern based on the same Islamic laws created by himself and his allies. It seems that if bin Salman fails in this endeavor, the legitimacy of the state will face challenges, particularly in the eyes of various social groups and especially the religious elite.

Percutaneous coronary intervention (PCI) is the preferred treatment for ST-elevation myocardial infarction (STEMI); however, reduced left ventricular ejection fraction (LVEF) remains a critical issue post-PCI. Serum uric acid (SUA) has emerged as a biomarker linked to cardiovascular events and may be associated with LVEF. This study aims to investigate the relationship between SUA levels and LVEF in STEMI patients treated with primary PCI and identify potential biomarkers for predicting patient outcomes.  This prospective study was conducted at Afshar Hospital, Shahid Sadoughi University of Medical Sciences of Yazd, from September 2019 to March 2021. Participants included 254 consecutive ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI. Exclusion criteria were contraindications for angiography, history of myocardial infarction, PCI, CABG, NSTEMI, thrombolytic treatment, kidney diseases, gout, or alcoholism. Demographic data, clinical history, SUA levels, and echocardiographic parameters were collected. Statistical analysis was performed using SPSS version 20.0, with significance at p<0.05.  81.49% of patients were male, with a mean age of 57.7±11.47 years. Hypertension was the most prevalent condition (42.9%). SUA levels did not significantly differ between patients with LVEF below and above 40% (p=0.39). However, smoking was significantly associated with reduced LVEF (p<0.001). A weak negative correlation between SUA and LVEF was observed in males (p=0.012) but not in females (p=0.097). Overall, a weak negative correlation between SUA and LVEF was statistically significant (p=0.05).  Our findings revealed a weak but statistically significant overall negative correlation between SUA and EF. Further research with larger, more diverse populations is necessary to elucidate the relationship between SUA and cardiac function in STEMI patients.

Paraquat is one of the chemical herbicides with high toxicity. In case of incorrect consumption, this chemical causes fatal poisoning in people, especially those active in the field of agriculture. Nowadays, using compounds of natural origin to improve or reduce the harmful effects of agricultural pesticides is one of the important issues that has attracted the attention of researchers in this field. Quercetin as a natural flavonoid is found in large quantities in fruits and vegetables. As a kind of natural antioxidant, this compound has great power in removing free radicals. The purpose of this research was to evaluate the protective effects of quercetin on ovarian toxicity caused by paraquat in rats.

To conduct this experimental research, 30 adult Wistar rats with an average age of 6 to 8 months and a weight range of 160 to 180 gr were randomly divided into 5 experimental groups including 6 rats in each group. Paraquat (1.25 mg/kg, intraperitoneally) was injected into mice. Then quercetin was injected intraperitoneally in concentrations of 50, 100, and 200 mg/kg. The negative control group received only normal saline. After 24 hours, the animals were sacrificed and their ovaries were evaluated for changes in oxidative stress indices.

The results showed that paraquat significantly increased the reactive oxygen species (ROS), protein carbonyl, and lipid peroxidation, and significantly decreased glutathione content and survival of ovarian tissue cells when compared with the control group (P<0.001). The results showed that different concentrations of quercetin could inhibit the lipid peroxidation reaction caused by paraquat toxicity, and the positive control group had a statistically significant difference compared to the negative control group (P<0.001). By administering quercetin in different concentrations, we saw a decrease in the production of lipid peroxidation. From a statistical point of view, quercetin at the concentration (mg/kg) of 50 had a significant difference with the positive control group (P<0.01) and this significant difference was also evident at the concentrations of (mg/kg) 100 and 200 (P<0.0001). Increasing the concentration of quercetin was associated with improved performance in inhibiting paraquat toxicity.

Results showed that quercetin can be useful as an effective antioxidant combination in improving oxidative stress indicators and ovarian tissue of mice. Quercetin can reduce paraquat-induced oxidative damage in rat ovarian tissues in a dose-dependent manner. Quercetin can potentially be used to control ovarian toxicity, modulate or inhibit oxidative factors, strengthen the immune system, and strengthen the antioxidant system in animal models. Probably, it can be used as a kind of safe supplement in combination with other drugs affecting the immune system. However, this hypothesis along with the effect of other drug interactions should be confirmed using appropriate in vivo studies. Understanding the process of cell death caused by paraquat and the inhibitory effect of natural antioxidants on it provides a new road map for future studies to develop new therapeutic strategies.

Knee osteoarthritis is an important age-related public health issue characterized by progressive loss of articular cartilage and as a result functional impairment, disability and reduced quality of life. The present study aimed to investigate the effect of an Orem-based self-care educative supportive nursing system on the quality of life in patients with knee osteoarthritis.

This semi-experimental study was conducted on 130 patients with knee osteoarthritis, who were selected as available samples and randomly assigned to the intervention and control groups. In addition to demographic characteristics, information related to patients’ quality of life was collected using EQ-5D questionnaire. With the help of Oram’s health status checklist, first, self-care deficiencies were determined as nursing diagnoses. Then, based on that, the educational support system that includes education, consultation and follow-up of the patients were done for the patients of the intervention group. The interventions were carried out during 6 weeks (every week a session of 45-60 min). Data were collected before and three months after the intervention. The data were analysed using SPSS21 software through descriptive and inferential statistics (p=0.05).

The overall score of quality of life in the intervention and control groups before the intervention was 48.4±13.1 and 45.8±12.9, respectively; however, it increased to 70.2±19.4 and 61.8±17.6 after the intervention, respectively. In other words, there was a significant difference between the mean score of quality of life dimensions in the intervention and control groups after the intervention (p<0.05).

According to the results of this study, Orem’s self-care model has had a positive significant effect on subjects’ quality of life.

Arthralgia is the most common complaint of people with knee osteoarthritis. The present study was conducted to examine the effect of proprioceptive neuromuscular facilities on the pain intensity of people with knee osteoarthritis.

In this semi-experimental intervention research, 50 people suffering from knee osteoarthritis referred to the orthopedic centers of Darab City in 2021 were selected through convenience sampling. They were assigned to the intervention and control groups using random block allocation. In the intervention group, proprioceptive neuromuscular facilities exercises were performed over eight weeks and two sessions each week for 30-45 minutes. A visual analog scale was used to assess pain intensity three times before the intervention, during the fourth week, and at the end of the intervention. The data was analyzed using SPSS version 21 and the repeated measurement ANOVA test.

There was no statistically significant difference in the mean pain intensity scores of the two groups Before the intervention(p<0.05). However, the patients receiving proprioceptive neuromuscular facilities reported significantly less pain intensity than those in the control group after the intervention (P=0.001).

The results could serve as a basis for further research on non-pharmacological interventions, such as Proprioceptive Neuromuscular Facilitation. If confirmed by additional studies, these exercises can be utilized as a non-pharmacological technique alongside pharmaceutical methods to alleviate the pain experienced by patients with knee osteoarthritis, which is one of their primary and common complaints.

In relation to the housing of the disadvantaged, the possibility of access to a suitable housing for every Iranian household in accordance with the household's needs in such a way that the housing concern does not exceed other areas of the household's life and stable and safe access to the household's housing is also guaranteed, showing the ideal vision of the housing sector in documentary studies, is related to disadvantaged groups. The purpose of this study is to achieve the set of strategies and the general form of realistic and effective programs in the field of housing support for the deprived and low-income groups, which, while determining the limits and type of government intervention in relation to housing and different economic groups, will make the target groups enjoy support programs faster. This study is based on the combined model of SWOT strategic analysis and QSPM strategic planning model and examines the findings of studies and the results of interviews with experts in the field of geography and urban planning. SWOT analysis showed that 1- Ignoring the lack of simultaneous use of the process of management and operation of low-income housing based on the participation of local social institutions and non-governmental organizations 2- Lack of necessary knowledge or disregard for the diversity of needs of the deprived and disregard for Special Characteristics of Target Groups 3. The imbalance between the benefits of different individuals in different groups in relation to support programs has led to the inefficiency of the policies of the deprived and the enjoyment of supportive housing for this group. "Empowerment programs" and "Attracting participation by exploiting local capacity and internal capacities by developing and diversifying empowerment", along with a general balancing policy to increase capacity in non-governmental sectors based on household participation. Faster households have support programs Provides housing and participation of all stakeholders in planning.

Gastric cancer, which is considered a main global health concern, is the sixth most frequent cancer and the second cancer-related death worldwide. This survey was designed to systematically review the anti-gastric cancer effect of all the organic and inorganic nanoparticles in in vitro, in vivo and clinical trials. The investigation followed the PRISMA guidelines and the findings were recorded in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-Analysis Facility (SyRF) database. We searched the publications in various English databases such as Scopus, Web of Science, EMBASE, PubMed and Google Scholar with no specified publication time frame to obtain papers regarding the anti-gastric cancer properties of nanoparticles. The following terms including: “nanoparticles”, “gastric cancer”, “anti-gastric cancer”, “metal nanoparticles”, “organic nanoparticles”, “inorganic nanoparticles “, in vitro”, clinical” and “in vivo” were applied in this study. Out of 11189 papers, 31 papers including 19 in vitro (45.5%), 3 in vivo (13.6%), 3 clinical trials (13.6%), and 6 in vitro / in vivo (27.3%) up to 2023 met the inclusion criteria for discussion in this systematic review. The most widely used nanoparticles were organic nanoparticles such as polylactic acid, poly lactic-co-glycolic acid (PLGA) (16, 80.0%), followed by inorganic nanoparticles such as silver nanoparticles (13, 41.9.0%). This review study showed the high anti-gastric cancer potential of a wide range of organic and non-organic NPs through their activity through some mechanisms such as induction of apoptosis, gene therapy, drug delivery, etc. However, more studies, especially in a clinical setting, are needed to confirm their anti-gastric effects and accurate mechanisms.

Ectopia cordis is a congenital anomaly. In this disorder, the heart is located completely or partly outside its original location in the chest. This deformity has three cervical, thoracic, and abdominal forms and the neck form is the most common form. Up to now, many factors such as genetic defects, the receipt of chemical products (mercury, cocaine, ethanol), the consumption of teratogenic plants, exposures to radiation, infectious agents (such as BVD virus), and the use of medications (calcium suppressants) have been known factors in Ectopia cordis occurrence. Immediately after birth, a female Holestein was referred to a veterinarian clinic in Semnan City Iran,. During the clinical examination, according to the location of the heart outside the body and under the sternum, ectopia cordis anomaly was detected.

The prevalence of Coronary artery ectasia (CAE) varies from 0.3 to 5% in different countries. The prevalence of CAE has varied in different parts of the world and the study of risk factors can be effective in the process of diagnosis and treatment of patients, we reviewed patients who underwent coronary angiography for 5 years to determine the prevalence of isolated CAE and its associated risk factors.

A retrospective analysis was conducted on 16600 patients who underwent coronary angiography at Shahid Sadoughi and Afshar hospitals between March 2015 to April 2020. Diagnosis and confirmation of CAE was defined as a vessel diameter greater than 1.5 times the normal diameter of the vessel, which must be confirmed by at least two cardiologists. Demographic variables, angiography and echocardiography reports were included in our final analysis.

Isolated CAE was diagnosed in 287 (1.7%) patients. After triple-vessel disease (53%), the left anterior descending artery (LAD) was the commonest affected vessel by ectasia 16% (46 cases). Diffuse isolated CAE was diagnosed in 52% of LAD, 76.6% of Right coronary artery (RCA), and 74.1% of left circumflex artery. A significant association was seen between the vessel involved and the nature of ectasia (p<0.001).

In our study, the occurrence of isolated CAE was similar to other studies. This condition often affects all three major vessels of the coronary arteries, and is commonly categorized as type 1, which involves diffuse involvement of the arteries based on the Markis and Harikrishnan Classification.

Releasing the picture of the accused during the preliminary investigation stage of the crime, according to articles 91 and 96 of the Criminal Procedure Code approved in 2012, is subject to criminal liability, in some cases it can also conform to the jurisprudentially unlawful titles. On the other hand, to fulfill the function of informing, the media needs to take pictures of the accused in the preliminary investigation stage of the crime and since it is legally and judicially forbidden to release the pictures, they pixelate and then release the picture of the accused. Therefore, this research investigated in the first step, the effect of blurring the face of the accused in recognizing their identity in the news reports of the 18.30 national media in the period of 1400-1401. In the next step, using the documentary-library method, the feasibility of application of the title of backbiting in the release of these pictures was investigated. The results of the statistical analysis showed that blurring the picture of the accused has no effect on not identifying their identity in the news reports. As a result, the release of these pictures results to revealing the attributive deficiencies of the accused to be revealed. If it is so, then it will be an instance of backbiting, if not, the sentence of accusation will follow.

 Cholemic nephropathy (CN), a renal dysfunction caused by bile acids, is a severe complication of chronic liver damage and bile duct ligation (BDL), which may lead to complete kidney failure.

 This study investigated the protective effect of ellagic acid on CN in cholestatic rats.

 Sixty male Wistar rats weighing about 180 - 200 g were randomly divided into 6 groups for in vivo investigation. The rats were randomly divided into 5 groups of 10. Cholestasis was induced in rats by closing the bile ducts; then, the animals were treated with different doses of ellagic acid (10, 25, and 50 mg/kg). Then, the induction effect of cholestasis and the protective effects of ellagic acid on serum and urinary factors, oxidative stress indices, and histopathological changes in liver and kidney tissue were investigated.

 Bile duct ligation in rats led to an increase in serum and urinary factors. It was also associated with increased reactive oxygen species (ROS), lipid peroxidation, glutathione (GSH) oxide form, decrease in antioxidant systems, GSH and severe histopathological changes, and fibrosis of the liver and kidney tissues. Another finding of this research was the beneficial effect of ellagic acid in improving serum and urinary factors, oxidative stress indices, and histopathological changes.

 Due to its antioxidant properties, ellagic acid can potentially serve as a novel therapeutic approach for treating kidney damage caused by increased serum levels of bile acids.

Coronary artery anomalies (CAAs) are associated with an increased risk of cardiovascular events, including sudden cardiac death, especially in young people. A different prevalence has been reported based on the USED diagnostic modality. This study aimed to determine the prevalence and type of these anomalies using coronary computed tomography angiography (CCTA).

This single-center retrospective study was performed on 3016 consecutive cases who underwent CCTA for cardiac symptoms from March 2015 to August 2020 and the prevalence and types of CAAs were evaluated.

38 cases (overall prevalence of 1.26%) including 21 men (55.3%) and 17 women (44.7%) were retrospectively diagnosed with CAAs. The most common anomalies were the Anomalous origin of LCX from the right coronary sinus (11 cases, 28.9%), Anomalous origin of RCA from the left coronary sinus (11 cases, 28.9%), and Anomalous origin of LM from the right coronary sinus (6 cases, 15.8%). There was no difference in the prevalence of CAAs in terms of patient’s gender (P value=0.16) and age (P value=0.61).

The prevalence of CAAs among patients who underwent CCTA was 1.26%. The most common anomalies observed were the anomalous origin of the LCX arising from the right coronary sinus, the anomalous origin of the RCA arising from the left coronary sinus, and the anomalous origin of the LM arising from the right coronary sinus. These findings emphasize the importance of CCTA in detecting and characterizing coronary artery anomalies, which may have clinical implications for patient management and treatment decisions.

 Knee osteoarthritis is a prevalent chronic musculoskeletal problem among older people, leading to pain, muscle weakness, and a decline in the quality of life.

 This study aimed to investigate the impact of proprioceptive neuromuscular facilitation techniques on the muscle strength of patients with knee osteoarthritis.

 This quasi-experimental study was conducted on all patients with knee osteoarthritis who visited orthopedic offices in Darab City in 2021. A non-probability sampling method was used to select 50 eligible patients, who were then divided into 2 groups: an experimental group and a control group. The allocation of participants into these groups was done by a block randomization method. The experimental group underwent proprioceptive neuromuscular facilitation techniques for eight weeks, with two sessions per week lasting 30 - 45 minutes. In contrast, the control group received only routine care. Muscle strength in both groups was evaluated using the manual muscle test scale before, four weeks, and immediately after the intervention. The collected data were analyzed using SPSS 21, descriptive statistics (such as central tendency and dispersion indices), independent t, chi-square, Fisher’s exact, Mann-Whitney U, Kolmogorov-Smirnov, Wilcoxon, and repeated measures ANOVA tests. A significance level of 0.05 was considered.

 Fifty patients (24% male and 76% female) with a mean age of 53.6 ± 10 completed this study. There was no statistically significant difference by mean scores of muscle strength parameters, including degree (2.8 ± 0.4 vs. 2.8 ± 0.3), the percentage of normality (45 ± 10 vs. 44 ± 12), and scale (2.8 ± 0.4 vs. 2.8 ± 0.3) between the intervention group and the control group on the before of intervention, respectively. However, a significant difference was observed by degree (3.6 ± 0.6 vs. 2.8 ± 0.3; P = 0.001), the percentage of normality (65 ± 14 vs. 45 ± 9; P = 0.001), and scale (3.5 ± 0.6 vs 2.8 ± 0.3; P = 0.001) between the intervention group and the control group, respectively, at the end of the intervention.

 The proprioceptive neuromuscular facilitation techniques could improve the muscle strength of patients with knee osteoarthritis. If this finding is confirmed in other studies, healthcare workers should use these techniques for the benefit of these patients.

The coronary angiography results in a group of patients with myocardial infarction (MI) are normal or near-normal; which is diagnosed as myocardial infarction with non-obstructive coronary arteries (MINOCA). This study aimed to compare the mortality rate and risk factors between MINOCA and myocardial infarction with obstructive coronary artery (MI-CAD).

This retrospective cohort study was conducted from January 1, 2018, to December 31, 2019. A total of 679 patients admitted to Afshar Hospital in Yazd with a diagnosis of ST-elevation myocardial infarction (STEMI) from 2018-2019 who underwent primary Percutaneous Coronary Intervention (PCI) were enrolled in the study. Demographic, and clinical variables, ECG finding and one-year mortality, were extracted using MI registry data from the Yazd Cardiac Research Center.

The estimated frequency of MINOCA was 4.6%. Patients with MINOCA (
47.14±6.2) were younger than patients with MI-CAD (57.61±9.1) (P <0.0001). MINOCA patients (47.4±9.47) had a considerably greater left ventricular ejection fraction (LVEF) than MI-CAD patients (43.5±6.8) (P =0.018). The majority site of MI in MINOCA patients was located in the non-anterior wall (p <0.0001). A comparison of MINOCA and MI-CAD patients' one-year mortality revealed no significant difference (P =0.07).  

The prevalence of patients with MINOCA in Yazd was similar to other communities. Although these patients probably do not have a better prognosis, despite being younger and having better LV systolic function and lower CAD risk factors.

Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are novel inflammatory markers known for inflammatory and cardiovascular diseases. This study aimed to examine PLR and NLR as predictors of calcification aortic stenosis (CAS) severity.  This study investigated a total of 155 individuals who were referred to Chamran Heart Center in Esfahan, Iran between 2018 and 2019. The participants included 53 patients with severe AS, 50 patients with mild to moderate AS, and 52 individuals as a control group. The severity of aortic stenosis was evaluated in all participants using echocardiography. The study also calculated the PLR and NLR from CBC.  The results of this study indicate that there was no significant difference in PLR among those with severe AS (108±66), mild to moderate AS (103±43), and the control group (110±50) (p=0.813). However, the NLR was significantly higher in those with severe AS (3.13±2.3) compared to mild to moderate AS (2.08±0.7) and the control group (2.1±1.3) (p=0.019). Age and diabetes mellitus were found to be significant and independent factors correlated with PLR, while the severity of AS was not. Additionally, severe AS was found to be an independent predictor of NLR, along with age and sex.  This study elucidated the intricate relationship between inflammatory markers and CAS, emphasizing the significance of NLR as an indicator of pro-inflammatory and anti-inflammatory contrast. Surprisingly, PLR exhibited no relationship with CAS severity. we suggest that future studies examine the effect of ethnic variation on the relationship between inflammatory markers and CAS. Also, explore the potential impact of additional inflammatory markers on new indices that may provide stronger predictive value for CAS severity.

Culture is the highest element that has a fundamental role in the existence of any society. Along with the political and economic dimensions, culture is also one of the dimensions of society and its most important, and the development of a society depends on the development, excellence and deepening of culture in accordance with it in all layers of society. Therefore, although culture has always been considered, but its generalization and understanding of its importance in human life and its impact on all social, political, economic and ... behaviors due to the complex and changing conditions of the new age, has led to a more prominent consideration To take. The present study, by identifying the issues of strategic cultural management of the country, while determining the accurate and accepted criteria by the scientific community and compiling it in the form of a conceptual model, after validation, has identified, sorted and prioritized existing and desirable issues and issues. The method in this research is evolutionary. In this research, two field methods and a scientific and specialized library method were used to collect data. To analyze the collected information, the rules of modeling in the evolutionary research method have been used. The most important method of data analysis in the evolutionary research method, "speculation, selection, processing" of the dimensions and descriptive components of the model, has been collected based on information. Findings of this research have been compiled in three sections: concepts or content (basic, structural and applied), structure and systems (macro, intermediate and micro) and products (human and effective factor; technology and cultural act; and goods, services and works).

Background and

Ellagic acid is a natural polyphenol compound with potential antioxidant properties that is present in most fruits, seeds, and vegetables. Therefore, this study was designed to investigate the effects of ellagic acid administration on the liver damage model caused by thioacetamide in rats.

In this experimental study, 60 male Wistar rats weighing approximately 200 grams were randomly divided into six groups (n=10). Liver damage was caused by a single dose (100 mg/kg) administration of thioacetamide for three consecutive days. Different doses of ellagic acid (10, 25 and 50 mg/kg) were administered to the sick mice as a single dose for three consecutive days. Finally, 24 hours after the last injection, biochemical factors (ALP, AST, ALT, LDH, bilirubin, total protein), oxidative stress markers (LPO, ROS, FRAP, GSH), ammonium ion concentration, and movement activity of the mice were examined. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis.

Thioacetamide led to a significant increase in serum biochemical factors and oxidative stress markers in the studied groups (P<0.05). In addition, the amount of ammonium ion in the plasma, as a key effective factor in hepatic encephalopathy, was greatly increased in animals receiving thioacetamide (P<0.05). Administration of ellagic acid in different doses significantly reduced liver damage and plasma ammonium concentration (P<0.05).

The results of this study showed that ellagic acid reduced liver damage caused by thioacetamide through its antioxidant activities.

After the collapse of the Soviet Union, the field of competition in Central Asia and the Far East became available for Iran and Turkey. The ideological vacuum caused by the collapse of Syria led to the fact that Turkey, with the support of the West, could use the theory of strategic depth to seek ways of influence and alliance with the countries of the region. This country shares historical, cultural and linguistic commonality with the countries of Central Asia and the Caucasus. In this regard, Turkey was able to promote its ideology by establishing effective institutions in promoting Pan-Turkist ideas. The arena of competition between Iran and Türkiye in the region has become complicated and it seems that the two countries have clashed geopolitical interests in the region. Turkey's ideology is based on secular thinking and Iran's is based on nation-centered thinking. Therefore, the intersection of ideological ideas has also occurred in different fields. In recent years, new campaigns and processes of power are emerging in Central Asia and the Caucasus, which may have created a new structure of power play between regional and extra-regional countries. Regardless of the geopolitical value of this region, it is considered a geopolitical arena for Iran in competition with its other regional competitors, so the loss of strategic depth in this region will have a negative effect on Iran's ability to maneuver in competition with other regional competitors. Therefore, the research seeks to answer the question, "What are the components of the conflict between the geopolitical interests of Iran and Turkey in Central Asia and the Caucasus".

The current research aims to provide a comprehensive analysis of the clash of geopolitical interests of Iran and Türkiye and extract the geopolitical components of this issue. The current research method is qualitative and the data analysis strategy is inductive. Therefore, by using the descriptive-analytical approach and collecting data in a documentary-library form and by studying books, articles and also online resources, inferences have been made from the discussion.

Türkiye's foreign policy based on the theory of strategic depth is looking for a way to penetrate Central Asia using the Caucasus route. This is the most important gate for this country in order to develop economic relations and trade relations with the mentioned regions. Linguistic, racial and ethnic similarity, the framework of secular governments, the revival of Turkish nationalism using the concept of pan-Turkism and historical-cultural commonalities are the factors that lead to the use of the geopolitical approach of influence in the countries of the region and the clash of interests with the Islamic Republic of Iran. What was inferred in the research studies is the conflict of interests including political-ideological, political-nationalist, economic and Karabakh war components. The political and ideological problem has been created from the political systems, different attitudes and structures and the specific ideology of the ruler in the two countries. Türkiye has a secular attitude and Iran is nation-oriented. In the political and nationalistic issue, Turkey's emphasis is on ethnicity and pan-Turkism. The roots of this difference can be considered the thoughts of Turkish nationalism. In the economic field, due to sanctions and lack of attention to regional countries, Turkey's financial transactions with these countries are much more than with Iran. Finally, the Karabakh war, which had geopolitical reasons, increased the differences and the field of conflict was clearly defined.

The different and competitive roles of Turkey and Iran cause a clash of geopolitical interests in Central Asia and the Caucasus. Finally, the pattern of behavior of the two countries has been led to conflict, competition and confrontation. Iran's advantage over Turkey in these areas is Iran's common border with other countries, as opposed to Turkey's border of a few kilometers in Nakhchivan with Azerbaijan, so it can be claimed that Turkey practically does not have a border with this country. Also, Iran's traditional ties with the Transcaucasia peoples are that unlike the Armenian-Turkish relations, there is no feeling of dissatisfaction and insult to the past. As long as the two countries are in a similar situation in terms of the extent of power, they will consider any relations, behavior and developments with the countries of Central Asia and the Caucasus as vital, and we will witness serious differences between the two countries. This challenge will become more serious with the increasing power of Türkiye and Iran. Because the two countries seek to increase their geopolitical influence in the region by increasing their power. This role will cause the two countries' strategies to overlap, and as a result, the pattern of competition, conflict and confrontation between Turkey and the Islamic Republic of Iran will increase.

The mechanical flow meter is a widely used tool in various industries such as the oil industry. A pair of oval gears is used in the mechanical flow meter. The most important issue in the oval gear is the lack of uniformity in the shape of its teeth. This lack of uniformity prevents the gears from interfering with each other, for this reason, similar to the circular gear, it is not possible to machine.  For the oval gear machining, tool design, or the use of the wire-cut method is required. As a result, it is necessary to know the profile of oval gear teeth. Therefore, in this article, the relations governing oval gears have been investigated. In these relationships, the number of teeth, geometric dimensions, and equations of motion have been investigated. Then, it was modeled using the Gear-Otix software and with the help of the results of the relationships of the gears, the interference conditions of the two gears were checked in this software, and finally, the stress analysis of the gear was done by using Comsol software for the appropriate state. With the help of the created model, it is possible to produce this gear using the wire-cut method.

Tuberculosis is one of the most common infections that lead to death,; incidence of tuberculosis is higher in individuals with immune system deficiency. Candidates for receiving immunosuppressive drugs should be examined for the presence of latent tuberculosis, so that if this test is positive, appropriate treatment and prophylaxis measures for tuberculosis can be carried out for them. The purpose of this study was to screen patients who are candidates for receiving immunosuppressive drugs in terms of tuberculosis.

This cross-sectional study was conducted on the patients who were candidates for injectable immunosuppressive drugs hospitalized in Shahid Sadoughi Hospital between 2019 to 2020. Tuberculin skin test (TST) was taken from all eligible patients by the infection control unit of the hospital. Statistical analysis was done by SPSS V16. The P value less than 0.05 was considered statistically significant.

Participants were divided into three groups: healthy (TST=0-4), suspected (TST=5-9) and infected with tuberculosis (TST≥10); the frequency in the three groups was 83 (23.9%), 164 respectively. (47.3%) and 100 (28.8%). There was a significant relationship between the reason for referral to receive immunosuppressive drugs and the results of the TST test (P=0.003).

If the patients with rheumatology, dermatology disorders and kidney transplant candidates receive immunosuppressive drugs, they are at high risk of primary tuberculosis infection and activation of latent tuberculosis, and it is necessary for health workers to pay more attention to this issue.

Unrecorded alcoholic beverage consumption is a health problem in Iran. Extensive use of pesticides in agricultural products may lead to the presence of residues of these compounds in hand-made alcoholic beverages. There are claims that the producer of hand-made alcoholic beverages adds some drugs to increase efficiency. The objective of this study was to assess the presence of methamphetamine, methadone, tramadol, diazinon, phosalone, trichlorfon, mancozeb, and penconazole in homemade alcoholic drinks. Thirty hand-made alcoholic beverages were analyzed in this study. Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) and liquid-liquid extraction (LLE) were selected for samples' pretreatment. Gas chromatography-mass spectrometry (GC-MS) was used to identify diazinon, phosalone, trichlorfon, mancozeb, and penconazole and high-performance liquid chromatography (HPLC) was used to identify tramadol, methadone, and methamphetamine. This study showed that diazinon was detected in three samples (10% of the total samples) at 10.8 to 16.5 μg/L and Penconazole was detected in two samples (6% of the whole samples) at a range of 78.5 to 810.6 μg/L. However, Mancozeb, trichlorfon, and phosalone were not in alcoholic beverages. In addition, methadone, tramadol, and methamphetamine were not detected in any samples. The results of our research showed that hand-made alcoholic beverages contain pesticide residues, and the use of these beverages causes diseases in the body.

Background and

Mycotoxins are secondary metabolites of fungi that have carcinogenic effects. Ochratoxin A (OTA) is a highly toxic mycotoxin that can contaminate wheat grains and flour under various conditions of production, storage, and maintenance. Considering the carcinogenicity and mutagenicity of this toxin, it is necessary to monitor the contamination of wheat flour used in bakeries and to prevent this product from entering the bread supply chain. The aim of this study was to identify and determine the amount of OTA in wheat flour consumed by bakeries in Sari, during 2017 using high performance liquid chromatography (HPLC) method.

In this study, 30 samples of flour used in the preparation of lavash, barbari and sengak bread were collected from five different geographical areas of Sari (Mazandaran province) in 2017. The concentration of OTA was finally determined using HPLC device and through purification with an immunoaffinity column.

No concentration of OTA was observed in any of the tested samples. The results were in compliance with the mentioned reference values of OTA concentration in bakery products based on the Iranian National Standard Organization.

Based on the results, the flour used in breads is safe in terms of OTA. This amount is in accordance with the permissible limits set by the Iranian National Standard Organization and is acceptable for consumption.

Extensive application of zinc oxide nanoparticles has increased the likelihood of its release into the environment and subsequent human exposure and toxicity. The toxicity is thought to be a combined effect of intracellular particles and the release of dissolved zinc ions. 

This review outlines the possible mechanisms of zinc oxide toxicity in biological organs through in vitro and in vivo experiments. 

We reviewed articles published between 2001 and 2021. In this way, we did a manual search of Google Scholar and scientific databases, including PubMed, Web of Science, Scopus, and Embase, with keywords such as “zinc oxide nanoparticles”, “toxicity mechanism”, and “in vivo and in vitro studies”. The other qualified papers contained the history of identifying zinc oxide nanoparticles, the toxicity of metallic nanoparticles, and physical, chemical, and biological side effects with topical and systematic approaches.

The main mechanism suggested for zinc-based nanoparticles-induced cell damage is via the induction of increased levels of reactive oxygen species, which are oxidative stress markers. This mechanism has also been found to be a key mechanism for the cytotoxicity of other metal nanomaterials. Zinc-based nanoparticles were found to induce oxidative DNA damage, inflammation, progressive degenerative cell changes, cell cycle arrest, cytogenetic alterations, and ROS-triggered mitochondria-mediated apoptosis in human organs.

This review sheds light on the full understanding of in vitro and in vivo toxicity assessment of zinc oxide nanoparticles, highlighting the health concerns from the perspective of ZnO nanoparticles release to the ecosystem after their increasing application.

Multifunctional features of grid-connected inverters can be used for harmonic compensation of local load voltage and grid-injected current. But, in high-power grid-connected inverters, there is a challenge due to low switching frequency. On the other hand, simultaneous compensation of local load voltage and grid-injected current harmonics is an important issue in grid-connected inverters. Using a Unified Power Quality Conditioner (UPQC) at the Point of Common Coupling (PPC), an improved active harmonic compensation method is proposed which is appropriate for high-power low-frequency grid-connected inverters. The UPQC operates as a combination of a negative shunt virtual admittance and a negative series virtual impedance at the PCC. It suppresses the disturbances caused by local load variation and grid impedance change. Using a low-power, high-frequency UPQC, local load voltage and grid-injected current harmonics up to higher-order components are simultaneously compensated despite grid impedance changes and nonlinear local load variations. The control system is designed according to the impedance-based stability criterion to ensure the system's stability. The theoretical results are validated using different case study simulations in MATLAB/Simulink software.