فهرست مطالب hossein ali danesh

Historically, burn injuries have been accompanied by bad prognosis. With the advances in recovering fluids and the early excision of burn scars, the survival rate has enhanced for severe burn patients. The study aimed to analyze the epidemiology of burn injuries in Zahedan, Eastern Iran. This retrospective study examined 2173 burn patients for eight years. The research data were extracted from patients’ files and analyzed by SPSS 22 using the chi square test, t test and ANOVA. In sum, out of 2173 files, 2115 files were analyzed. About two-thirds (71%) of burns were due to flame, one-fifth (21.2%) to boiling water, and 8% to other means. There was a significant relationship between patients’ age, gender, burn percentage, burn degree, burn cause, burn occurrence season, hospitalization duration, and addiction or non-addiction status with rate of death (P < 0.001). In this region of Iran, burn is influenced by families’ culture, economy, urban service level, workplace, home heating devices, type of people’s clothing, and awareness. The statistical analysis of the existing data completely indicated the epidemiology of burns in Eastern Iran.

Combination chemotherapy is accepted as a high efficacy treatment for gastric cancer, whereas choice of standard treatment is unclear. Multiple chemotherapeutic regimens have been used to achieve higher efficacy and lower toxicity. This study was designed to evaluate the treatment results of advanced gastric cancer with Capecitabine and Oxaliplatin regimen.
Subjects and All cases with documented gastric adenocarcinoma and advanced disease were candidates for receiving Xelox regimen (Capecitabine – 750 mg/m2/twice daily/ 1-14 days and Oxaliplatin 125 mg/m2 in 1st day).
Twenty five cases with advanced gastric cancer entered in study while 24 cases continued treatment protocol and were evaluated. Mean age was 59.5 ± 12.1 years (range: 20-75), male and female cases were 66.7% and 33.3%, respectively. All cases received at least four cycles of Xelox regimen. Overall response rate was 74.99% with 29.16% complete response. Overall survival rate was 13 ± 0.53 months and DFS (disease-free survival) was 6 ± 1.09 months. Extremities neuropathy (62.5%), headache (45.8%) and muscle cramps (29.2%) were the most common complains. Haematological changes were rare and 16.7% of cases had mild cytopenia. Treatment related death was not observed.
Xelox regimen is a safe and highly effective first line treatment for gastric cancer; however, considering it as first line therapy needs larger studies.

This study aimed to compare the serum leptin levels in infants suspected of congenital hypothyroidism. In addition to investigate the relationship between serum levels of leptin with T4 and TSH. Subjects and In the present case-control study, 100 neonates under 30 days of age were selected randomly from those who had been hospitalized in Zabol Amir-Almomenin hospital between years 2012 to 2013. Thorough clinical examination by a pediatrician and evaluation for possible congenital hypothyroidism, the subjects were divided into two groups (case and control) homogenized in terms of age and gender. Case group consisted of neonates with suspected congenital hypothyroidism, and controls without. Blood sampling was taken from each neonate after obtaining a written consent form from parents Serum leptin, T4 and TSH were measured by ELISA method. The data were analyzed using software SPSS ver. 20 using of independent t-test and Pearson correlation by considering the level of 0.05 error. The serum leptin level was significantly higher among the suspected hypothyroidism than controls (P ≤ 0.05). In addition, there was an inverse relationship between TSH and T4 levels (r=-0.512, P ≤ 0.05). There were no significant relationships between the serum leptin level in regards to age and weight (P ≥ 0.05). Based on the results of this study, in infants with congenital hypothyroidism, serum leptin increases independently of age and weight. Therefore, leptin serum level may be considered as a criteria for assessment of thyroid gland function.