فهرست مطالب kalimoddin i. momin

Among the many natural ingredients and pharmacological drugs that contain heterocyclic compounds, benzothiazole (BTA), and its derivatives stand out as particularly significant. BTA analogs provide a great deal of structural diversity, which has been helpful in the quest for new therapeutic drugs, and BTA itself displays a variety of pharmacological features. Because each BTA derivative has its own unique set of pharmacological effects, it is clear that this class of chemicals is intriguing. Medicinal chemistry based on BTAs is a hot subject right now, with lots of new research and discoveries happening in the field. In particular, there are a plethora of BTA-based compounds that have found widespread clinical use as highly effective medications for a wide range of disorders. Current developments of BTA-based compounds in medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial, and other medicinal agents are presented in this work systematically and thoroughly. More effective diagnostic agents, pathologic probes, and BTA-based medications that are both active and less toxic, can be rationally designed, according to the authors of this review study.

Electronic absorption spectra, infrared spectroscopy, nuclear magnetic resonance, molar conductance, and elemental analysis are some of the physicochemical methods used to characterize the 4-chloro-N'-[(E)-(2,6-dihydroxy phenyl) methylidene] benzohydrazide (HBHDH) molecule that has been synthesized. The results of the analysis show that the metal and ligand formed a 1:2 ratio. According to the spectra, the ligand HBHDH forms tridentate coordination spheres with metal ions using an ONO bond. Complexes with Fe(II), Co(II), Ni(II), Cu(II), and Mn(II) have an octahedral shape because of this. In contrast to the tetrahedral structure of the complexes created with Zn(II), Cd(II), and Hg(II), the Pd(II) complex takes on a square planar layout. According to the molar conductance values in DMF, the complexes do not undergo electrolysis. It has been determined that the metal complexes and Schiff's base HBHDH ligand have antibacterial action. The antibacterial efficiency of each combination and ligand against E. coli bacteria is higher than that of regular streptomycin.Candida albicans (MCC 1439) and Saccharomyces cerevisiae (MCC 1033) have significant antifungal effectiveness, with their growth being inhibited by over 92% in the presence of Mn(II) and Fe(II) complexes, respectively.

Sodium trifluoromethanesulfinate (NaTFMS) is also known as “Laglois reagent” developed Quantitative 19F-NMR (QNMR) and also employed to determine the amounts of “Laglois reagent” in a mixture containing (NaTFMS) and other inorganic impurities, the amounts of NaTFMS can be measured by high-performance liquid chromatography, but it requires a high-purity standard sample.  NMR signal was affecting the response to determined by measuring longitudinal relaxation time (T1) to be 1.2 s is the main parameter ‘‘delay time (d1) between two scans”. Internal reference for the quantitative analysis was used as a trifluoroethanol of sodium trifluoromethane sulphinate by water as solvent. Six experiments with different weights of sodium NaTFMS/TFE and the relative standard deviation (R.S.D.) were repeated and the results are less than 2.0% and also detection limit of 19F-QNMR upto 0.85 mg. 19F-QNMR was calculated and the R.S.D.s of results were less than 2% of each mixture of amount NaTFMS.