فهرست مطالب khosro jalali dehkordi

Breast cancer accounts for 23% of all neoplasias in women, which significantly impacts their physical, mental, and social aspects of life. This study investigated the effect of 8-week aerobic exercise alone or with ferulic acid administration combined with or without zinc oxide on the prevention of breast cancer in a rat model.

A total of 27 rats were randomly divided into 9 groups of 3 rats each as follows: 1) Exercise only; 2) Exercise + ferulic acid; 3) Exercise + zinc; 4) Exercise + ferulic + zinc; 5) Ferulic acid only; 6 ) Zinc; 7) Ferulic + zinc; 8) Positive controls; and 9) Negative controls. In the first week, the aerobic exercise protocol consisted of a 10-minute warm-up period at a speed of 10 m/min for 20 min, which increased to a speed of 18 m/min for 30 min. The ferulic acid supplement was administered to rats intraperitoneally using insulin syringes with a volume of 200 µL. After the last training session, the rats’ breast tissue samples were excised, and the expression levels of BCL2, Bax, and caspase-3 were measured by the real-time polymerase chain reaction method. The data were analyzed by one-way ANOVA and Tukey’s post hoc test (P≥0.05).

The findings showed that intermittent exercise plus ferulic acid-zinc supplementation decreased the BCL2 level in the breast cancer group (P=0.004). Intermittent training supplemented with ferulic acid-zinc increased Bax and caspase-3 levels in the breast cancer group (P=0.001).

Aerobic exercise combined with ferulic acid and zinc nanoparticles inhibited cell apoptosis promoted by breast cancer in rats.

Alzheimer's is an advanced nervous disorder related to aging. This research aims to determine the effect of eight weeks of aerobic training and linalool, cineole, and β-Bourbonene on preventing and improving Alzheimer's disease. Mice randomly divided into 8 groups: Control group, Mice induced Alzheimer's disease treating with β-amyloid (Alzheimer group), Alzheimer's mice were treated with bioactive compounds of herbal medicine (Linalool with a concentration of 25 mg/kg, Cineol with a concentration of 100 mg/kg, β-Bourbonene with a concentration of 0.20 μg by gavage for 8 weeks, Alzheimer+Biocompounds group), Alzheimer's mice treated with aerobic exercise with a moderate intensity treadmill for 8 weeks (Alzheimer's+Training group), Alzheimer's mice treated with bioactive compounds of herbal medicine and aerobic exercise for 8 weeks (Alzheimer+Biocompounds+Training group), Healthy mice were first treated with the bioactive compounds of the herbal medicine, and then were induced with Alzheimer's (Biocompounds+Alzheimer group), Healthy mice were first treated with aerobic exercise using a treadmill with moderate intensity for 8 weeks and then induced Alzheimer's disease (Training+Alzheimer group), Healthy mice were first treated with the bioactive compounds of the herbal medicine and aerobic exercise for 8 weeks and then induced Alzheimer's disease (Biocompounds+Training+Alzheimer group). Compared to other groups, the IL1β/CASP3/PSEN1/APP level improved in mice first treated with aerobic exercise and biocompounds. Oxidative capacity was improved by exercise training and bioactive compounds. In addition, exercise training and bioactive compounds regulated the miRNA-210 in the hippocampus of the mice with Alzheimer's. We could conclude that consuming biocompounds and aerobic training can manage and prevent Alzheimer's.

Diabetic cardiomyopathy refers to changes in the heart as a result of impaired glucose homeostasis, leading to ventricular dysfunction and associated with mitochondrial dysfunction. Since sports activity is known to protect the heart, the aim of the present study was to investigate aerobic exercise and the effective substance crocetin on the expression of Myod gene in the heart tissue of an experimental model of elderly prediabetic rats.

In this experimental trial, 25 elderly female c57bl6 male mice with prediabetes (20 mg/kg peritoneal injection) aged 14-16 weeks and weighing 30-35 grams were divided into 5 healthy control groups, prediabetic, prediabetic + aerobic exercise, pre-diabetic + crocetin, pre-diabetic + aerobic exercise + crocetin were divided. aerobic training was performed for eight weeks, five sessions per week. Mice received crocetin 30 mg/kg/day by intraperitoneal injection. Myod expression was measured by Real Time PCR method. To analyze the data, one-way analysis of variance and Tukey's post hoc test were used (P≥0.05).

Myod gene expression was significantly decreased in the prediabetic group compared to the healthy group (P=0.01). Myod gene expression was significantly higher in the pre-diabetes group + aerobic exercise + crocetin supplement and diabetes group + aerobic exercise + crocetin supplement than other groups (P=0.01).

It seems that intermittent aerobic exercise and crocetin both alone and simultaneously are effective in improving Myod gene expression in prediabetic heart tissue. Therefore, the use of periodic aerobics and crocetin n is recommended in pre-diabetes conditions of old age

Obesity leads to various chronic conditions and investigating its causative factors is of health and clinical and significance to humans. Doing physical exercises regularly and consuming proper diet are frequently recommended for achieving health benefits and resolving the various complications of obesity. This study examined the question whether performing moderate intensity aerobic exercises combined with spirulina, a seaweed rich in probiotics and antioxidants, can improve the lipid profile, body composition and function in overweight women.

We examined the associated variables linked to obesity in 20 volunteer women in a pre- and post-test design over eight weeks of intense aerobic exercises based on an established protocol, compared to the controls. We assessed cardiovascular endurance, and variables like lipid profile, weight, body mass index, and lean muscle mass in response to exercising plus spirulina consumption versus the controls.

The exercise combined with spirulina significantly reduced blood triglycerides and LDL while raising the HDL. The treatment significantly reduced the body weight, fat and BMI while increasing the muscle strength and Vo2max compared to those of the control group.

Combining moderate intensity aerobic exercises with spirulina supplements significantly reduced the body weight, fat deposits, and BMI while increasing the muscle strength and Vo2max in overweight and obese women.

Breast cancer is the most common cancer. Therapeutic strategies reduce neurogenesis in treated patients. The present study aimed to assess the effect of endurance training along with the combination of gallic acid and Kaempferol on neurogenesis in the hippocampus caused by the side effects of paclitaxel in mice with breast cancer.

The mice were randomly assigned to six groups (n=6), including control group, the group with breast cancer injected with 4T1 cell line, the cancer group that received paclitaxel (10 mg/kg), cancer group treated with paclitaxel and gavage supplemented with Kaempferol and gallic acid, cancer group treated with paclitaxel and endurance exercise, the cancer group treated with paclitaxel and endurance training and supplements. Gene expression was measured by the Real Time-Polymerase Chain Reaction (PCR) method. Genes were selected using bioinformatics software. In this study, statistical analysis was performed using GraphPad Prism software (version 9). Data were calculated using one-way analysis of variance (ANOVA) with Tukey's post hoc test. Results were presented as mean±standard deviation. A p-value less than 0.05 was considered statistically significant.

The expression of VEGFα/ARC/CREB increased significantly (P<0.05) due to the consumption of gallic acid, kaempferol, and endurance training in mice treated with paclitaxel. Moreover, the expression level of VEGFα/ARC/CREB genes increased in the endurance training group and the supplement (P<0.05). On the other hand, breast cancer has increased the expression of HIF1α gene (P<0.05). Endurance training and supplement consumption significantly reduced the expression of the HIF1α gene (P<0.05).

Endurance training, along with gallic acid and Kaempferol, regulated the expression of ARC, VEGFα, HIF1α, and CREB1 genes in the brain tissue of mice with breast cancer treated with paclitaxel.

This research aimed to investigate the effect of 8 weeks of interval training and the use of cineole, linalool, and bourbonene on MAPK/Arc gene expression and learning in Alzheimer’s disease (AD) rats.

In this experimental study, 40 AD rats were randomized into eight groups, including (1) control, (2) AD, (3) AD+aerobic training (AT), (4) AD+linalool, cineole, and bourbonene (LCB), (5) AD+AT+LCB, (6) AT+AD, (7) LCB+AD, and (8) AT+LCB+AD. AD was induced by injecting amyloid-beta (Aβ1)-42 into the hippocampus of rats. The interval training protocol was performed five days per week for eight weeks before and after AD induction. Linalool at a concentration of 25 mg/kg, cineole at a concentration of 10 µM, and β-bourbonene at a concentration of 10 µg/mL were used for eight weeks. One-way analysis of variance was used for between-group comparisons, and Tukey’s test was used for pairwise comparisons at P≤0.05.

AD induction caused a significant decrease in MAPK/Arc gene expression in hippocampal tissue (P=0.001). Interval exercise and consumption of three herbal drugs significantly increased gene expression of Arc (P=0.001) and MAPK (P=0.001). AD induction decreased learning (P=0.001). Interval exercise and consumption of three herbal medicines caused a significant increase in learning (P=0.001).

Interval exercise and using three herbal medicines have more favorable effects on improving MAPK/Arc gene expression and learning in AD than each alone.

Myocardial infarction (MI) is the death of the heart muscle tissue that causes damage and inflammation. Quercetin consumption and interval training can probably prevent the progression of this condition in the active parts of the myocardium by activating angiogenesis pathways and stimulating hypoxia factor-1a (HIF-1a) at the onset of infarction. This study investigated the effect of high-intensity interval training (HIIT) and quercetin nanoliposome consumption on angiogenesis indexes in the heart tissue of MI rats.

In this experimental study, 30 male rats weighing 250 ± 20 grams were randomly divided into five groups: 1) MI + training, 2) MI + supplement, 3) MI + training + supplement, 4) healthy control, and 5) MI. MI was induced by subcutaneous injection of isoprenaline hydrochloride at a dose of 80 mg/kg. Groups 2 and 3 received quercetin daily at a dose of 0.25 mg/kg by gavage. Groups 1 and 3 performed five sessions of training protocol per week. Then, the Smirnov-Kolmogorov, one-way analysis of variance, and Tukey’s post hoc test were used to analyze the data (P < 0.05).

Interval training and quercetin had a significant effect on increasing vascular endothelial growth factor (VEGF) and HIF-1a gene expression (P < 0.001).

The combined effect of interval training and quercetin consumption may prevent the progression of MI by activating VEGF and HIF-1a in the early stages and play an effective role in preventing this disease.

Although the beneficial role of exercise and CBD oil in Myocardial infarction (MI) has been reported, the interactive effect of swimming training (ST) and CBD Oil (CO) consumption is still not well known. Therefore, the purpose of this study was to investigate the effect of eight weeks of CBD oil consumption on Ceramide gene expression in the heart tissue of rats suffering from heart infarction along with swimming exercise.

In this experimental trial, 25 ovariectomized rats with myocardial infarction were divided into five groups, including (1) Healthy control (HC), (2) Myocardial infarction (MI) (3) Myocardial infarction+ Swimming training (MI+ST), (4) Myocardial infarction + 50 mg/kg of CBD oil consumption (MI+CO 50), and (5) Myocardial infarction + 50 mg/kg of CBD oil consumption+ Swimming training (MI+. +CO 50 + ST). Myocardial ischemia was induced by subcutaneous injection of isoproterenol (50 mg/kg intravenously) in myocardial infarction rats. Groups 3 and 4 received 50 mg/kg CBD as gavage on a daily basis for eight weeks, and groups 2 and 4 performed swimming training five days a week. One-way analysis of variance (ANOVA) with Tukey’s post hoc test was performed to analyze the findings (P < 0.05)).In this study, 25 rats were divided in 5 groups including: (1) healthy control, (2) patient control, (3) endurance training (3 days a week for one month), (4) recipients of mesenchymal stem cells (1 × 106 cells / Kg), and (5) simultaneous recipients of endurance training and mesenchymal stem cells. Alkaline phosphatase gene expression was assessed by RT PCR and the amount of osteopontin synthesis was measured by immunohistochemistry procedure.

Ceramide in the MI group had a significant decrease compared to the healthy control group (p=0.01). Compared to the MI group, only the MI group + swimming + CBD supplement showed a significant increase in Ceramide (p=0.01).

Eight weeks of CBD oil consumption and swimming training can reduce heart tissue damage by increasing Ceramide expression.

The research aims to determine the effect of aerobic exercise, Gallic acid, and Kaempferol on neurogenesis caused by the side effects of the paclitaxel drug in mice with breast cancer.

36 female BALB/c mice were randomly divided in to six groups, including the negative control group, breast cancer group (induced with 4T1 cell line injection), cancer-chemotherapy group (10 mg/kg injected paclitaxel), cancer mice treated with chemotherapy+supplement (Gallic acid and Kaempferol), cancer mice treated with chemotherapy+aerobic exercise, cancer mice treated with chemotherapy+supplement+aerobic exercise for eight weeks. The gene expressions were measured by the Real Time-PCR method. Genes were selected using bioinformatics software.

The expression level of JAG1 was decreased in the chemotherapy group. Moreover, the expression level of JAG1 was significantly reduced by Gallic acid, Kaempferol supplements, and aerobic exercise compared with the breast cancer and cancer-chemotherapy groups. In addition, Gallic acid and Kaempferol supplements, along with aerobic exercise, significantly declined JAG1 gene expression compared with other groups. The expression levels of the BDNF and NGF genes were increased in the cancer group treated with chemotherapy+supplement and chemotherapy+aerobic exercise group. The expression genes of BDNF and NGF in the cancer group treated with chemotherapy+supplements+aerobic exercise significantly increased compared to other groups.

Aerobic exercises+supplements declined the side effects of paclitaxel and improved the neurogenesis.

Alzheimer's disease is a progressive neurological disorder associated with aging. The research aims to determine the effect of eight weeks of aerobic exercise and consumption of linalool, cineol and beta bourbonin on the prevention and improvement of the cognitive process of mice with Alzheimer's disease.

48 C57BL/6 female mice with an average age of 15 months were randomly divided into 8 groups of 6 each. Bioactive compounds include linalool with a concentration of 5.2 mg/kg, cineole with 100 mg/kg, beta bourbonin with a concentration of 72 mg/kg, administered by gavage, and moderate-intensity aerobic exercise for 8 weeks. Bioinformatics analysis of Bdnf, Ngf and Creb genes selected and measured by qPCR-Real Time.

The expression of Bdnf, Ngf and Creb increased in Alzheimer+ bioactive compounds, Alzheimer+ aerobic exercise and Alzheimer+ bioactive compounds + aerobic exercise compared to Alzheimer group. Aerobic exercises and consumption of bioactive compounds before induction of Alzheimer's disease enhance Bdnf, Ngf, and Creb, indicating a protective effect in Alzheimer's disease. A synergistic effect was observed in the group of bioactive compounds + aerobic exercise + Alzheimer on the expression of genes compared to other groups. In addition, the rate of new object recognition in Alzheimer + bioactive compounds + aerobic exercise compared to other groups was increased.

The decrease in Bdnf, Ngf, and Creb gene expression in the bioactive compounds+aerobic exercise+Alzheimer group was slighter than in other groups, indicating a protective effect on the process of Alzheimer's.

The use of cannabidiol oil supplement can control cardiovascular risk factors. Exercise can also be effective in the rehabilitation of heart attack by strengthening the heart tissue. Therefore, the purpose of this study was to investigate the effect of eight weeks of cannabidiol oil consumption and swimming exercise on the expression of AEA gene in heart tissue of rats suffering from myocardial infarction.

The present research was experimental. 25 rats with myocardial infarction were divided into five groups of 5 series: 1) healthy control, 2) MI, 3) MI + exercise, 4) MI + CBD, and 5) MI + exercise + CBD. Myocardial ischemia was induced by subcutaneous injection of isoproterenol (85 mg/kg intravenously) in myocardial infarction rats. The swimming training program was for eight weeks. The CBD supplement was given at a dose of 50 mg/kg during eight weeks. The data of the research was analyzed by one-way ANOVA and Tukey's post hoc test (p≥0.05).

AEA in the MI group had a significant decrease compared to the healthy control group (p=0.01). Compared to the MI group, only the MI group + swimming + CBD supplement showed a significant increase in AEA (p=0.01). Compared to the MI group, only the MI+swimming+CBD supplement group showed a significant increase in AEA (p=0.01).

Eight weeks of CBD oil consumption and swimming exercise can reduce heart tissue damage caused by isopretenol -induced myocardial infarction by increasing the expression of AEA.

 Glioblastoma (GBM) is one of the most aggressive tumors, health-threatening, and resistant to available treatment approaches for people worldwide.

 This study aimed to evaluate effects of swimming training and a supplement comprising four nanoliposome herbal extracts in a rat model with mid-brain tumor.

 In this experimental study, 56-male-Wistar rats (230 ± 20 g) were divided into eight groups (n = 7): Normal group, model group, model + exe group, model + lipo, model + extract, model + lipo-extract, model + extract-exe, model + lipo-extract + exe. Mid-brain tumor model was induced by injection of the C6 glioma cell line (5 × 105 cell suspension) using stereotaxic techniques in the substantia nigra area of rats. Consumption of nanoformulation of herbals extract (100 mg/kg/day), crude extract (100 mg/kg/day), and swimming training (30 min, 3 days/week) were performed for six weeks. P53, Hras, IL-10, and Casp8 were studied by bioinformatics analysis. We assessed the relative expression of genes in the mid-brain tumor via the quantitative Real-Time PCR (qRT-PCR) method. Beam test and sciatic functional index assessed nerve function and motor coordination.

 In silico analysis highlighted substantial genes with significant differential expression compared to healthy status as biomarkers in pathogenesis conditions. The expression level of the P53 and Hras increased with swimming training and nanoliposomes enriched complex complement. Besides, the expression of the IL-10 and Casp8 decreased with swimming training and nanoliposomes enriched complex complement.

 Our findings show that swimming training and nanoliposome-enriched combined supplements in rats can possibly be considered effective complementary medicine for motor impairment recovery induced by the brain tumor in the substantia nigra area.

Considering the role of diet and the use of natural antioxidants in addition to exercise, the attention of researchers has been drawn to take further advantage of the effects of exercise to improve cellular metabolism. Despite the favorable role of exercise and antioxidants on heart health, the simultaneous effect of exercise and consumption of propolis (prepared by bees) is not yet known. This study aimed to investigate the effects of endurance training and propolis against oxidative and myocardial stress in diabetic ovariectomized rats.

This experimental study was conducted on 36 female Sprague Dawley rats aged 12-16 weeks and weighing 220-250 grams. Six rats were included in the healthy control group. Diabetes was induced in 30 overiectomized rats by intraperitoneal injection of streptozotocin (40 mg/kg). Then, the diabetic animals were divided into five groups of six including diabetic ovariectomized control, sham, propolis, endurance training, and endurance training + propolis. Rats in the training groups trained for eight weeks, five sessions per week, with 55-75% VO2 max. Moreover, propolis was administered 100 mg/kg/day by peritoneal injection. The level of Pro-oxidant-antioxidant balance (PAB) and expression of HSP72 and NF-κB genes were measured.

HSP72 expression was significantly higher in the propolis, endurance training, and endurance training + propolis groups. The levels of NF-kB and malonaldehyde were significantly decreased in the ovariectomized diabetic rats (P<0.05). Expression of HSP72 in the endurance training and endurance training + propolis groups were significantly higher than in the propolis group. Moreover, NF-kB in the endurance training and endurance training + propolis groups were significantly lower than in the propolis group (P<0.05). The value of PAB in the propolis and endurance training + propolis groups were significantly lower than in the ovariectomized diabetic rats (P<0.05).

Exercise and consumption of propolis seem to synergistically improve the protective HSP72 pathway and reduce oxidative stress in heart tissue following estrogen dysfunction and diabetes. However, the interaction of the two depends on endurance training.

Although the beneficial role of exercise and antioxidants in multiple sclerosis (MS) has been reported, the interactive effect of aerobic training (AT) and royal jelly (RJ) consumption is still not well known. Therefore, the aim of the present study was to investigate the effect of five weeks of ET and RJ consumption on glycemic indices of MS rats.

In this experimental trial, 49 female Sprague-Dawley rats of EAE model weighing 180-210 gr were divided into seven groups based on their motor disability, including (1) experimental autoimmune encephalomyelitis (EAE), (2) sham (Sh), (3) 50 mg /kg of royal jelly consumption (RJ50), (4) 100 mg /kg of royal jelly consumption (RJ100), (5) aerobic training (AT), (6) AT+RJ50, and (7) AT+RJ100. In order to investigate the effects of EAE on the variables, 7 healthy rats were included in the healthy control group (HC). AT was performed for five weeks, four sessions per week at a speed of 11-15 m/min for 30 minutes, and RJ was injected intraperitoneally with the determined dose daily. To analyze the findings, one-way analysis of variance and Tukey's post hoc test were used (P≥0.05).

Insulin levels in the RJ50, RJ100, ET, ET+RJ50 and ET+RJ100 groups were significantly lower than the EAE group (P=0.01).

It seems that aerobic training combined with royal jelly consumption has a synergistic and favorable effect on improving glycemic indices of MS rats.

In this study, the effects of aerobic exercises and encapsulated ginger extract (GE) into chitosan nanoparticles (CNPs) were investigated on atrial natriuretic peptide (ANP) gene expression and cardiac histopathology in rat models of myocardial infarction.

The 25 male rats were divided into five groups: Isop (85 mg/kg), Isop + CNPs, Isop + GE-CNPs, Isop + AE, and Isop + GE-CNPs + AE. The rats performed AE on a rodent treadmill five days per week for six weeks. GE-CNPs were gavaged to rats at a dose of 500 mg/kg for six weeks. After the end of the treatment period, the expression of ANP genes was carried outby Real-Time PCR.

Based on our findings, the highest amount of collagen deposition was in the heart tissue of patient groups and the patient group treated with chitosan nanoparticles (P<0.05). Besides, the results of real-time PCR showed that the changes in ANP gene expression were significant only in the groups treated with aerobic exercise and ginger extract (P<0.05).

Regular aerobic exercises with nano-drug supplements such as ginger extract encapsulated into CNPs can reduce cardiac fibrosis and regulate ANP gene expression.

The aim of this study was to investigateto the effect of 12 weeks of resistance circuit-based training on markers of bone metabolic and hormonal in elderly men.30 elderly men with mean and standard deviation of age: 67.63 ± 4.82 years; weight: 75.82 ± 8.89 kg and body mass index: 27.53±3.28 kg/m2 were randomly divided into two groups of combined training and control. The resistance exercise training was performed at 30–55% ofthe one-repetition maximum (1-RM), three times per week for 12-weeks, while the CON group maintained their regular lifestyle. The hormonal and bone metabolic markers including serum 25-(OH) D3,parathyroid hormone (PTH), osteocalcin (OC), alkaline phosphatase (ALP), calcitonin and calcium were measuredbefore training and after 12weeksexercise intervention. The results of analysis of covariance showed a significant increase in the calcitonin levels (14.80± 2.70) vs. 12.67± 3.75 ml/dl, p = 0.037) and calcium (9.70±0.65 vs. 9.09±0.47 ml/dl, p = 0.006) in the resistance training group compared to the control group showed intervention after 12 weeks.The findings of the present study showed that 12 weeks of resistance circuit-based training led to a significant improvement in some hormonal markers and bone metabolic in the elderly. Further studies with a long-term follow-up should be considered to confirm these findings.

The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a protective role against cardiovascular disease. Therefore, the aim of the present study was to investigate the effect of eight-week resistance training (RT) and the use of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in myocardial infarction (MI) models.

In this experimental study, 25 rats were randomly divided into five groups including (1) control (C), (2) MI, (3) MI+RT, (4) MI+grape seed, and (5) MI+RT+grape seed. MI was induced by subcutaneous injection of isoprenaline (85 mg/kg). Grape seed nanoparticles were daily administered at a dose of 150 mg/kg for 8 weeks, and RT was performed 5 days a week. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P≤0.05).

MI models showed decreased expression of PGC-1α, PPARγ, and UCP-1 genes in cardiac tissue (P=0.001). However, RT combined with the use of grape seed nanoparticles had a significant effect on increasing the expression of PGC-1α (P=0.001), PPARγ (P=0.002), and UCP-1 (P=0.003) genes in the heart tissue of MI model mice.

The consumption of grape seed nanoparticles along with RT has more effects on improving the expression of PGC-1α, PPARγ, and UCP-1 genes in MI than either alone. Therefore, the use of grape seed nanoparticles together with RT is recommended in case of MI.

Cannabidiol (CBD) oil consumption can positively contribute to controlling the cardiovascular risk factors. Exercise can also be effective in rehabilitating myocardial infarction by strengthening muscle tissue. This study, therefore, aimed to evaluate the effect of eight weeks of swimming training together with CBD oil consumption on PI3K and ERK gene expression in the heart tissue of rats with myocardial infarction.

In this experimental trial, 25 ovariectomized rats with myocardial infarction were divided into five groups, including 1) control, 2) MI 3) MI +training, 4) MI+supplement, and 5) MI +training+ supplement groups. Myocardial ischemia was induced by subcutaneous injection of isoproterenol (50 mg/kg intravenously) in myocardial infarction rats. Groups 3 and 4 received 50 mg/kg CBD as gavage on a daily basis for eight weeks, and groups 2 and 4 performed swimming training five days a week. One-way analysis of variance (ANOVA) with Tukey’s post hoc test was performed to analyze the findings (P<0.05).

Induction of myocardial infarction contributed significantly to reducing PI3k and ERK gene expression in the heart tissue (P=0.001). However, swimming training with CBD oil consumption contributed significantly to increasing PI3K (P=0.003) and ERK (P=0.001) gene expression in the heart tissue of rats with myocardial infarction.

Seemingly, swimming training along with CBD oil consumption had more favorable effects on improvement of PI3K and ERK gene expression levels in myocardial infarction than either alone. Therefore, it was recommended that CBD oil together with swimming training should be employed when dealing with myocardial infarction.

Diabetes is a type of metabolic disorders that are associated with long-term hyperglycemia nevertheless nutrition and exercise are two factors that can improve blood glucose levels. This study investigates the effect of eight weeks of combined exercise and Propolis supplement on glycemic indices in women with type2 diabetes. 

In this applied research, 60 women with type 2 diabetes referred to Shiraz Medical Center were selected as a statistical sample and divided into 4 groups of 15 including: 1) placebo, 2) Exercise with placebo, 3) Exercise with propolis and 4) Propolis. During eight weeks, groups 3 and 4 received propolis in the form of 500 mg capsules three times a day (morning, noon and night) after each meal. Groups 2 and 3 also performed three to four sessions combined training (resistance-aerobic) per week. Resistance training performed with an intensity of 60 to 70% of a maximum repetition and aerobic training performed with an intensity of 65 to 80% of maximum heart rate. Blood samples were taken to specify glycemic index and insulin resistance, in two stages of pre-test and post-test. 

Exercise, propolis consumption and exercise simultaneously with propolis consumption led to a significant reduction in fasting blood glucose, insulin, insulin resistance and glycosylated hemoglobin (P≥0.05);Also, exercise with propolis consumption compared to exercise and propolis had a greater effect on lowering fasting blood glucose, insulin, IR and glycosylated hemoglobin (P≥0.05).

It seems that exercise and propolis alone can have positive effects on glycemic indices of diabetic patients; nevertheless combination of exercise and propolis has More favorable effects on improving glycemic indices than each one alone in Non insulin dependent diabetes.

Artificial intelligence analysis based on the gene list obtained from the DisGeNET database identified the important genes involved in the heart damage process. Data enrichment highlighted the apoptosis signaling pathway as a vital pathway in cardiovascular risk. Hence, we estimated the binding affinity of chemical and plant bioactive molecules for cytochrome-c protein. Here, we performed to evaluate the effect of eight weeks of resistance training (RT) with Tribulus Terrestris (TT) consumption on the mechanism of apoptosis in the heart tissue of rats exposed to stanozolol.

Thirty-five male rats were divided into seven groups: (1) Control, (2) Stanozolol (ST), (3) ST + 100 mg / kg TT, (4) ST + 50 mg / kg TT, (5) ST + RT (SRT), (6) S + RT + 100 mg / kg T (SRTT100), and (7) ST + RT + 50 mg / kg T (SRTT50). Differential gene expression was measured by q-RT-PCR. In bioinformatics analysis, the apoptosis signaling pathway was defined as a critical process in heart damage. In addition, adverse effects of Tribulus Terrestris and stanozolol on heart tissue were detected through the apoptotic pathway by molecular docking.

Resistance training along with 100 mg/kg reduced CRP and cytochrome-c Moreover, 100 mg/kg TT as a more favorable effect than 50 mg/kg TT

we showed the beneficial effects of Tribulus Terrestris, the plant’s bioactive compound that can reduce cardiovascular risks by impairing the formation of apoptosome assemblages and inflammation.

The activation of inflammatory reactions is essential immediately after the onset of myocardial infarction (MI). On the other hand, the path of inflammatory activators should be controlled to prevent the recurrence of MI. In this vein, the aim of this study was to examine the effect of eight weeks of interval training and quercetin nanoliposome consumption on nuclear factor kappa B (NF-κB) and fibroblast growth factor 2 (FGF-2) gene expression in the heart tissue of MI rats.

In this experimental study, 30 male rats, aged approximately 6-8 weeks, were randomly divided into five groups including MI + training, MI + supplement, MI + training + supplement, healthy control, and MI. The MI was induced by the subcutaneous injection of isoprenaline hydrochloride at a dose of 80 mg/kg. Quercetin was daily administered at a dose of 0.25 mg for 8 weeks, and interval training was performed 5 days a week. NF-κB and FGF-2 gene expressions were measured by the real-time polymerase chain reaction. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P<0.05).

Training significantly increased NF-κB gene expression in the MI+ training, MI + supplement, and MI + training + supplement groups (P=0.001) while significantly decreasing FGF-2 gene expression in the MI group (P=0.04).

Interval training may prevent the negative effects of MI by reducing pro-inflammatory gene expression in the heart tissue, leading to improved cardiovascular function and the prevention of this disease.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating factor of the central nervous system that leads to decreased balance and increased risk of falls. The aim of this study was to investigate the interactive effects of endurance training (T) with royal jelly (RJ) consumption on the motor balance of rats with MS. 

In this experimental study, 56 rats with MS (using complete Freund’s adjuvant) were divided in 7 groups of eight animals, including: 1) control (MS), 2) Sham (royal jelly solvent), 3) 50 mg/kg RJ, 4) 100 mg/kg RJ, 5) T, 6) T+RJ50, 7) T+RJ100. Rats in the royal jelly consumption groups received the prescribed doses of royal jelly peritoneally each day for 5 weeks. Also, rats in the endurance training groups performed endurance training on a rat treadmill for five weeks, five sessions per week, each session 30 minutes at a speed of 11 m/min. At the end of 48 hours after the last training session and royal jelly consumption, the motor balance of rats was measured using a rotarod device. Also, the weight of brain cerebellum tissue was measured by a digital scale. The one-way analysis of variance with Tukey’s post hoc test were used to analyze the findings (P≥0.05). 

The duration of motor balance in the T, T + RJ50 and T + RJ100 groups was significantly higher than the MS group (P = 0.001); also, in the T + RJ50 and T + RJ100 groups, it was significantly higher than the RJ50 and RJ100 groups (P = 0.001). 

It appears that training and royal jelly consumption have an interactive effect on improving motor balance, and improving motor balance is training-dependent. Given the existence of effective physiological mechanisms, it seems necessary to conduct further studies by examining the pathological and physiological aspects.

Diabetic cardiomyopathy is a complication of type 2 diabetes that can lead to myocardial cell autophagy through Beclin-1 and light chain 3 proteins. The aim of this study was to evaluate the effects of 8 weeks of continuous and intermittent aerobic exercise with resveratrol supplementation on Beclin-1 and LC3 gene expression in the heart tissue of diabetic male rats.

 For this purpose, 56 male Wistar rats with mean (age 40-50 weeks and weight 430-373 g) were randomly divided into 8 groups (n = 7) control (C), diabetic (D), saline (S), Resveratrol (Sup), Continuous exercise (E), Interval exercise (HIIT), Continuous exercise/Supplement (E+Sup), Intervalt exercise/Resveratrol (HIIT+Sup).  Diabetes was diagnosed by intraperitoneal injection of streptozotocin at a dose of 50 mg / kg body weight. Continuous training rats trained three days a week for 8 weeks at a speed of 15 meters per minute.  The intermittent training protocol also included 10 one-minute sets with an intensity of 50% vo2max on the treadmill and two minutes of rest between sets, starting at 14 meters per minute and increasing rapidly by two meters per minute each week.  Data were analyzed using two-way analysis of variance at the α (α ≥0.05) level.

 The results showed that Beclin-1 and LC3 in the diabetic induction group had a significant decrease compared to the healthy control group (P = 0.001). Compared with the diabetic group, the diabetic + exercise + supplement group showed a significant increase in Bcline-1 and LC3 (P = 0.001).

  Exercise combined with resveratrol supplementation can increase Beclin-1 and LC3 autophagy factors” which inhibit apoptosis and reduce heart tissue damage in diabetics.

The apoptosis process as a common status in heart injuries could be imposed significantly by hyperglycemia chronically. Therefore, the aim of this study was to investigate the inhibitory effects of concurrent training and antioxidant supplementation individually and in combination on biogenesis and function of mitochondrial in the heart tissue of diabetic rats with STZ.

In this experimental study, fifty male Sprague Dawley rats were classified into five groups (n=10 each group): healthy rats as control, diabetic rats, diabetic combined resistance/endurance training, diabetic rats which consumed supplementation vitamin E and C, and the combined supplementation and training. Here, we calculated changes in genes expression based on artificial intelligence methods and evaluated genes expression in apoptotic influencing combined training and antioxidants vitamins consumption in heart injured models by streptozotocin via Real-Time PCR. Combination training including, respectively, resistance training, 5 days a week with increasing intensity of 5-45% of rat weight and endurance training on treadmill increasingly from 10-30 minutes and intensity of 40-75% of maximum speed during 8 weeks. Data were analyzed by two-way ANOVA (P<0.05).

the relative expression of PGC1α and Tfam were significantly decreased between healthy control and diabetes controls group. The results indicated that significantly increased of PGC1α and Tfam in the training(P<0.05), supplement(P<0.05) and combination groups(p<0.05). In addition, in this study, it was observed that supplementation and exercise had an increasing effect on the expression of PGC1α and Tfam genes. On the other hand, glucose concentration and weight of rats treated with supplementation and exercise were significantly reduced compared to other groups (P<0.05).

Based on the results, interaction between antioxidant supplements and exercise reduced the glucose concentration and improved the mitochondrial biogenesis of heart tissue, while the combination of these two interventions compared to the effect of each alone, the effect has more.

The use of herbal supplements along with exercise is common among people to treat chronic diseases and metabolic disorders. The present study aimed to investigate the effect of eight weeks of swimming training with CBD oil consumption on the expressions of NF-kB and 5-HT1A genes in the heart tissue of rats with myocardial infraction.

In this experimental study, 20 myocardial infraction rats were divided into four groups of five series: 1) control; 2) training; 3) CBD; and 4) CBD + training. To investigate the effects of myocardial infarction induction on the research variables, five healthy rats were placed in a healthy control group. Induction of myocardial ischemia was performed by subcutaneous injection of isoproterenol. CBD groups received 50mg/kg/day of CBD oil by gavage for eight weeks. The training groups performed swimming training for five days a week. Real time-PCR was designed to measure the levels of cardiac tissue gene expression.

Although swimming, CBD consumption, and swimming combined with CBD decreased NF-kB gene expression and increased 5-HT1A gene expression in heart tissue (p<0.05), the combination of swimming training with CBD had a more significant effect on them (p<0.05).

Therefore, it seems that swimming training and CBD with the positive regulation of NF-kB and negative regulation of 5-HT1A of inflammatory factors in heart tissue can reduce inflammatory factors and improve cardiovascular health.