فهرست مطالب kosar bavarsad

Thyrotoxicosis is the name given to the clinical manifestations of the excess of thyroid hormones in the bloodstream. Thyrotoxicosis may induce increased fasting blood sugar (FBS) in patients of all ages, and has been reported in only few cases. The previous studies have shown that the prevalence of glucose intolerance in hyperthyroidism is 44-65% and may reverse to normal values after achieving euthyroid status. We discuss a 34-year-old woman who presented with thyrotoxicosis with enhanced FBS. The patient had a mild elevated FBS (110 mg/dl) when she had a severe thyrotoxicosis. After treatment with methimazole blood glucose level decreased to 85 mg/dl and by the third visit glucose level decreased to 82 mg/dl. It could be concluded that Mild hyperglycemia may co-exist with thyrotoxicosis and reduce to normal when the patient becomes euthyroid. Thus, early detection and treatment of thyroid hormones oversecretion can resolve the complications of both thyrotoxicosis and associated hyperglycemia.

Ziziphus jujuba stimulates the release of nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated.
Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (10mg/kg) intravenously, 3) sodium nitroprusside (SNP) (50µg/kg)NAME group received SNP before L-NAME and 4-6) three groups of Z. jujuba (100, 200 and 400mg/kg) that treated for four weeks and on the 28th day, L-NAME was injected. Femoral artery and vein were cannulated for recording cardiovascular responses and drug injection, respectively. Systolic blood pressure (SBP), Mean arterial pressure (MAP) and heart rate (HR) were recorded continuously. Maximal changes (∆) of SBP, MAP and HR were calculated and compared to control and L-NAME groups.
In L-NAME group, maximal ΔSBP (L-NAME: 44.15±4.0 mmHg vs control: 0.71±2.1 mmHg) and ΔMAP (L-NAME: 40.8±4.0 mmHg vs control: 0.57±1.6 mmHg) significantly increased (p0.05). All doses of Z. jujuba attenuated maximal ∆SBP and ∆MAP induced by L-NAME but only the lowest dose (100 mg/kg) had significant effects (ΔSBP: 20.36±5.6 mmHg vs L-NAME: 44.1±4.0 mmHg and ΔMAP: 20.8±4.5 mmHg vs L-NAME: 40.8±3.8 mmHg (p0.05).
Because long-term consumption of Z. jujuba extract, especially its lowest dose, attenuated cardiovascular responses induced by L-NAME, we suggest that Z. jujuba has potential beneficial effects in prevention of hypertension induced by NO deficiency.