leila heydari

In Islamic mysticism, intuitive epistemology is recognized as one of the fundamental methods for attaining divine truth and a deep understanding of religious concepts. This study examines the role and impact of intuitive knowledge on insight and religious understanding. Using a descriptive analysis method and relying on the works of great Islamic mystics such as Ibn Arabi, Rumi, Suhrawardi, Ghazali, and Attar of Nishapur, an effort has been made to explore the position of intuitive knowledge in spiritual conduct and its effect on individual and social transformation. The findings of the research indicate that intuitive knowledge takes the individual beyond the limitations of reason and senses, enabling them to achieve a deeper comprehension of religious and spiritual truths through inner experiences. This type of knowledge aids in enhancing religious insight and has positive effects on the individual's ethical and spiritual conduct. Additionally, intuitive knowledge can lead to improved social relationships and strengthened cohesion within the community. The conclusion of the study suggests that intuitive epistemology plays a significant role in shaping religious and spiritual understanding and can be employed as a practical approach to elevate the level of spirituality and ethics in society. It is recommended that future research focuses on examining the role of intuitive knowledge in the contemporary world and its applications in addressing today's ethical and spiritual challenges.

The concepts of good and evil are foundational topics in Islamic ethics and practical philosophy, consistently engaging the attention of philosophers and religious scholars. This study aims to comparatively analyze the teachings of Hadith and practical philosophy regarding these two essential concepts. Initially, the research introduces and examines the notions of good and evil in practical philosophy, where philosophers like Avicenna and Al-Farabi define good as the pursuit of perfection and moral virtues, and evil as the deficiency and deviation from this path. Subsequently, relevant Hadiths are explored, illustrating that good is characterized by obedience to God and adherence to divine commandments, while evil is depicted as disobedience and estrangement from divine mercy. In the comparative analysis section, the similarities and differences between these two perspectives are scrutinized. The findings indicate that both approaches emphasize the importance of justice, honesty, and benevolence towards others; however, they differ in defining the origin and nature of good and evil. Hadith teachings focus on religious and spiritual aspects, whereas practical philosophy centers on rational principles and social outcomes. The study concludes that integrating these two viewpoints can contribute to the formation of a comprehensive and applicable ethical system that encompasses both religious dimensions and rational principles. Suggestions for future research include examining the social and cultural impacts of these concepts and adapting traditional teachings to contemporary needs.

The G-protein receptor kinases are members of the most effective enzymes in the incidence of some important disease such as cardiovascular diseases, hypertension and Alzheimer’s disease. One of these enzymes is a protein with PDB code: 3v5w in the protein data bank. The in-silico study on the interaction of variety of inhibitor ligands with this enzyme was performed. The results of the interaction between selected ligands and target protein were investigated and analyzed using molecular screening by molecular docking simulation methods. The calculations of some factors such as binding energy between ligands and target protein, non-bonding interactions of ligands in the active site of enzyme and analysis of the result of molecular docking scoring were performed. The results were compared with a standard inhibitor (Paroxetine). Furthermore, to better evaluate and correct the selection of the lead compound, the related properties of absorption, distribution, metabolism, excretion and toxicity (ADMET) of high-scored ligands were compared with pharmacokinetic factors of Paroxetine using ADMETLab 2.0 data server platform. As the result, the compound L10, (4R,5S)-5-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one was introduced as a novel potent inhibitor ligand which has the better potency, more binding energy and more  appropriate pharmacokinetic properties.

Breast cancer is the most common cancer among women, with its prevalence and mortality rates increasing in recent years. The quality of life and psychological status of patients with breast cancer could be affected after diagnosis, especially during treatment. The main objective of this study is to investigate the long-term influence of breast cancer on the quality of life dimensions in survivors.

This is an ongoing longitudinal prospective study that was administered at the National Institute for Medical Research Development in Iran in March 2020. A total of 1,200 patients with breast cancer, who have completed their treatments, will be recruited from 5 referral medical centers located in Tehran to be followed for 5 years. Questionnaires for evaluating the primary and secondary outcomes will be completed by trained investigators during face-to-face interviews with each participant in three phases: immediately after treatment, 1 year later, and 5 years later. Data will be collected on socio-demographic status, quality of life, body image, hope, psychological problems (e.g., anxiety, depression, and mood), sexual function, and physical activity. Finally, data will be analyzed in each phase using SPSS 22.0 software.

It is the first nationwide, prospective, longitudinal study with large sample size, long-term follow-up, and broad research aims that will evaluate the quality of life-related factors in the Iranian breast cancer population to justify the existing gap in the literature.

Synchronization between the embryonic stage and the uterine endometrial lining is important in the outcomes of the vitrified-warmed embryo transfer (ET) cycles.

The aim was to investigate the effect of the exact synchronization between the cleavage stage of embryos and the duration of progesterone administration on the improvement of clinical outcomes in frozen embryo transfer (FET) cycles.

312 FET cycles were categorized into two groups: (A) day-3 ET after three days of progesterone administration (n = 177) and (B) day-2 or -4 ET after three days of progesterone administration (n = 135). Group B was further divided into two subgroups: B1: day-2 ET cycles, that the stage of embryos were less than the administrated progesterone and B2: day-4 ET cycles, that the stage of embryos were more than the administrated progesterone. The clinical outcome measures were compared between the groups.

The pregnancy outcomes between groups A and B showed a significant differences in the chemical (40.1% vs 27.4%; p = 0.010) and clinical pregnancies (32.8% vs 22.2%; p = 0.040), respectively. The rate of miscarriage tended to be higher and live birth rate tended to be lower in group B than in group A. Also, significantly higher rates were noted in chemical pregnancy, clinical pregnancy, and live birth in group A when compared with subgroup B2.

Higher rates of pregnancy and live birth were achieved in day-3 ET after three days of progesterone administration in FET cycles.

The rising frequency of methicillin resistant Staphylococcus aureus (MRSA) has led to an increased use of antibiotics such as macrolide, lincosamide, streptogramin B (MLSB ) for the treatment of S. aureus infections. Resistance to MLSB in S. aureus is commonly encoded by erm genes, which can be constitutive MLSB (cMLSB ) or inducible MLSB (iMLSB ). The purpose of this study was to determine the frequency of cMLSB , iMLSB , and MS phenotypes using D‑test and polymerase chain reaction (PCR) methods.

A total of 215 isolates of S. aureus were collected from January 2010 to May 2012 from Al‑Zahra Hospital in Isfahan. PCR was performed for detection of mecA gene on all isolates using specific primers. The frequency of MLSB ‑resistant isolates was determined using D‑test, and then a multiplex PCR was performed for detection of ermA, ermB, and ermC genes.

Among 215 S. aureus isolates examined, 82 (40.9%) were MRSA, and iMLSB , cMLSB , and MS resistance phenotypes had a frequency of 9 (4.18%), 58 (26.9%), and 11 (5.1%), respectively. Among nine isolates with iMLSB resistance phenotype, four isolates contained ermC gene, two isolates ermB gene, and one isolate ermA gene. Two isolates did not have any erm gene.

In the current study, cMLSB was the most frequent phenotype and ermC was the most common gene in iMLSB resistant phenotypes.