فهرست مطالب manjeshwar shrinath baliga

This study evaluates the predictive significance of salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and neck cancer patients who undergo curative radiotherapy/chemoradiotherapy.
The volunteers for the study included head and neck cancer patients that required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood samples before the start of radiation treatment and 24 h after the first radiation fraction of 2 Gy (before the start of the second fraction). Samples were assessed for the levels of blood and salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase by standard laboratory methods. Clinical tumor radioresponse was assessed one month after the completion of treatment as complete responders, partial responders, and nonresponders.
The results indicated a significant increase in the levels of amylase, lactate dehydrogenase, and lipid peroxides; and a concomitant decrease in the levels of glutathione P The results indicate that salivary lactate dehydrogenase can be a useful predictive marker to ascertain radiation-induced tumor regression in head and neck cancers.

Metals like copper, iron and zinc have been suggested to modulate free radical generation and carcinogenesis. In lieu of these observations, estimation of these metals is vital and most studies have been with the blood.
In the present study we estimated the levels of these metals in both serum and saliva of the head and neck (H&N) cancer patients and compared it with healthy age-matched control group. A correlation between the levels of these metals in the serum and saliva of respective H&N cancer patient was also assessed.
The subjects of this study were the clinically confirmed cases of H&N cancers visiting the Oncology Department of Medical College Hospital for treatment. Age and sex-matched healthy individuals were included as control group. The levels of iron, copper and zinc were estimated in whole saliva and serum by standard spectrophotometric methods.
When compared to the controls, the levels of iron and copper were higher in serum and saliva was high in the H&N cancer patients and statically significant (P=.0002 to P=.0001). On the contrary, there was a decrease in the levels of zinc but was not significant. There was significant correlation between serum and saliva with respect to the levels of iron, copper and zinc in H&N cancer patients and was statically significant (P=.0001).
The findings of this study indicated the role of metals in etiopathogenesis of H&N cancer. An assessment of the levels of metals in cancer patients might have prognostic and therapeutic implications. This study observed a significant positive correlation between serum and saliva which will go a long way in establishing saliva as a diagnostic tool complimentary to blood.

A Head and Neck (H&N) cancer severely affect the voice and compromises the patient’s vocal independence. The present study proposed to investigate the difference in the three vital components of voice the pitch, jitter and shimmer in H&N cancer patients and compared it with age matched healthy volunteers.
The voice parameters were ascertained in the freshly diagnosed H&N cancer patients and controls using the voice analysis software PRAAT and Dynamic Unidirectional AUD-59 XLR microphone in a sound proof voice recording laboratory
The result indicates that a considerable change in the three voice indices, the pitch, jitter and shimmer were observed. On a gender perspective it was observed that the changes in all the three indices were significant for men (p The results suggest that all individuals with any form of head and neck cancer will have some amount of voice problems even before the initiation of the cancer treatments and that the voice assessment is a vital aspect to be considered before initiation of the treatment.