فهرست مطالب maryam haddad

Erythropoietin plays a significant role in the growth of red blood cells, hemoglobin levels, and tissue oxygenation in critically ill patients, as well as anti-inflammatory and neuroprotective effects.

This study aimed to evaluate the effect of recombinant erythropoietin on improving COVID-19 patients.

This study was conducted on 20 COVID-19 participants with hemoglobin of ≥ 9. The inclusion criteria was at least one severe COVID-19 symptom/sign in this interventional study. The primary outcome was a combination of hospital stay length and paraclinical evaluation (LDH and hemoglobin level). The outcomes and side effects were evaluated on day 0 (before the intervention) and five (post-intervention).

The mean hemoglobin level was 10 ± 1.1 gr/dL in the intervention group and 8 ± 0.7 gr/dL in the control group posttreatment, indicating a significant difference between the groups (P = 0.04). The mean hospital stay length (6 ± 2 days) in the intervention group was significantly less than the control group (9 ± 4 days) (P = 0.001). At the end of the treatment, the mean LDH was significantly lower in the intervention group (503 ± 264 µ/L) than in the control group (725 ± 320 µ/L; P = 0.017).

According to the results, this study provides the first solid evidence for the positive effects of recombinant erythropoietin on COVID-19.

 As the first randomized clinical trial, this study evaluated the effect of Famotidine on the improvement of outcomes of hospitalized patients with COVID-19.

This phase III randomized clinical trial which was designed with two parallel arms, is a placebo-controlled, single-blind, and concealed allocation study, and recruited 20 patients (10 of them received Famotidine as treatment group and 10 received Placebo as control group). Oral Famotidine 160 mg four times a day was given to the COVID-19 patients until the discharge day or for a maximum of 14 days. Patients’ temperature, respiration rate, oxygen saturation, lung infiltration, lactate dehydrogenase (LDH) level, and complete blood count (CBC) were measured at the baseline (before the intervention) and on day 14 after the intervention or on discharge day. Length of stay in the hospital and length of stay in the ICU were also measured as secondary outcomes of the study.

The results showed a significant decrease in LDH (P=0.01), mean WBC (P=0.04) and length of stay (P=0.04) of patients with COVID-19 in the group treated with Famotidine compared to the control group. There was also a significant increase in oxygen saturation (P=0.01) in the group treated with Famotidine compared to the control group. Cough improvement was also higher in the oral Famotidine group compared to the control group (P=0.02).

This was the first clinical trial on the effect of Famotidine on the improvement of hospitalized COVID-19 patients, which indicated that high-dose Famotidine improves patients’ clinical signs and reduces the severity of the disease and duration of hospitalization.

Abdul-Rahman Jami was one of the most influential poets of the 9th century who had worksin poetry and mysticism, following previous poets. In this paper, Mathnawi of Al-Silsilah al-Dhahabhas been studied in terms of teaching topics and moral instructions. The main questions of the research are how was the Jim's educational insight, which level of the community he taughtmore and which methodswere used by him to teach.The review of the book shows that Jami appearedboth asa preacher and sociologist in the community and tried to transfer moral teachings and instructions to the audience through criticizing the social, religious, and mystical aspects of his society. The Sufis and the Kings were the most important corps that have been criticized.He believed that the hypocritical Sufisin appearance ruin human morality through hypocritical religion. The kings also recommend the two corners follow the principles of ethics through oppressed and impolite. The most important inscriptions of the poet include advising on theology, religious practices, adherence to teaching and inscription, avoiding piety and mischief, observance of justice, kindness and goodness, condemning defamation, suppressing and oversleeping