maryam pirasteh

 Inflammation and oxidative stress are contributed to cardiovascular diseases. Vitamin D (Vit D) has antioxidant and anti-inflammatory properties. In the current research, the effect of Vit D on cardiac fibrosis and inflammation, and oxidative stress indicators in cardiovascular tissues was studied in lipopolysaccharides(LPS) injected rats.

 Rats were distributed into 5 groups and were treated for 2 weeks. Control: received vehicle(saline supplemented with tween-80) instead of Vit D and saline instead of LPS, LPS: treated by 1 mg/kg of LPS and was given vehicle instead of Vit D, LPS-Vit D groups: received 3 doses of Vit D (100, 1000, and 10000 IU/kg) of Vit D in addition to LPS. Vit D was dissolved in saline supplemented with tween-80 (final concentration 0.1%) and LPS was dissolved in saline. The white blood cell (WBC) was counted. Oxidative stress markers were determined in serum, aorta, and heart. Cardiac tissue fibrosis was also estimated using Masson’s trichrome staining method.

 WBC and malondialdehyde (MDA) were higher in the LPS group than the control group, whereas the thiol content, superoxide dismutase (SOD), and catalase (CAT) were lower in the LPS group than the control group (P<0.01 and P<0.001). Administration of Vit D decreased WBC (P<0.001) and MDA (P<0.05 and P<0.001) while enhanced thiol (dose 10000 IU/Kg) (P<0.001), SOD (dose 10000 IU/kg) (P<0.001), and CAT (P<0.05 and P<0.001) compared to the LPS group. All doses of Vit D also decreased cardiac fibrosis compared to the LPS group (P<0.001).

 Vit D protected the cardiovascular against the detrimental effect of LPS. This cardiovascular protection can be attributed to the antioxidant and anti-inflammatory properties of Vit D.

Corrosion and scaling is one of the major and daily problems in the operation of water facilities and causes problems such as water loss, shortening the life of the facility, creating holes in the pipes, clogging, and pressure loss in the water supply network. Therefore, the purpose of this study is to determine the corrosion and scaling potential of drinking water supply sources in Meshginshahr. This descriptive cross-sectional study was conducted during the two seasons (summer and winter) in 2019. A total of 20 samples which were obtained by averaging 100 samples, were analyzed to determine the corrosion and scaling potential of water resources using Langelier and Ryznar indices in Meshginshahr. The results showed that the annual average of Langelier and Ryznar indices were -1.34 and 10.03, respectively, and the sources of drinking water supply in Meshginshahr were in corrosion and scaling state. Comparison of indicators and results obtained from this study showed that Meshginshahr water has corrosive properties, so it is necessary to constantly study the water supply sources of city and try for adjusting the pH and control other factors affecting corrosion, including concentrations of chloride, dissolved oxygen, and sulfate.