masomeh amini

Immunotoxins such as pseudomonas exotoxin are Molecules with a unique structure like toxin-antibody part. These immunotoxins are two functional which crossing the cell membrane and enters the target cell and destroy the cell. Toxin-based treatments are a widespread research field and can have broad applications in the biology and public health. Immunotoxins act selectively against cancer cells and have a good potential for detecting and targeting cancer cells. Specific immunotoxins to target immune cells due to the selection type antibody and antibodies are responsible for the identification of the target cells. Cancer is becoming a major cause of death in most developed countries. In order to have a strong factor in cancer repression, that agent must target the cancer cells directly and specifically. Often, but not always, immunotoxins are produced for disabling and killing cancer cells, that this issue is one of new therapeutic approaches in recently. Clinical aims to designing and create new cancer therapies focused with this approach, a lot of information about the toxin and intracellular pathways have been obtained. So, toxins in medicine are useful for the treatment of human disease and study of professional cellular functions. So, immunotoxins have a high potential for cancer treatment. Other applications of immunotoxins, including immune system regulation and treatment of viral diseases and parasites diseases. More research is needed to improve the immunotoxin effects and to reduce their side effects. On the whole, with design creative, clever and experienced programs, many human diseases, particularly cancers can be in a short period of time and faster than other methods of treatment that the treatment of long, to be treated. Following the design and implementation of clinical trials, the effects of immunotoxins on animal tumorigenic models were performed. In fact, in this study, we focus on the use of protein-bound toxins with bacterial and herbal sources and more specifically Pseudomonas immunotoxins which attached to antibodies to target cancer cells.

Myelomeningocele is a congenital central nervous system abnormality. Myelomeningocele children suffer from different aspects of the problem, including difficulty in mobility and behavioral disorders, especially aggression, but most of the time the behavioral disorders of these children are ignored. The aim of the present study was to assess the effect of painting therapy on reducing the aggression of a child with Myelomeningocele.

The current case report was conducted to assess the effect of 12 session of structured painting therapy on reducing the aggression of a 10-year-old Myelomeningocele child. In the present study, two questionnaires, The Aggression Questionnaire – AQ (Buss and Perry) and Children Aged 11-7 Year-Old Aggression Questionnaire, were used.

The scores obtained showed that this child's aggression reduced and painting therapy had good effects on reducing the aggression. The painting therapy can be used as an effective method for reducing the aggression of children with disability