فهرست مطالب masoud seyedian

There is little information about the prognostic role of preoperative serum albumin levels in postoperative outcomes following coronary artery bypass grafting (CABG). The aim of this study was to evaluate preoperative hypoalbuminemia as a predictor for complications after CABG.

This prospective observational study was conducted in 200 patients undergoing CABG in Ahvaz Golestan Hospital, 2020. The patients were classified into two groups based on pre-operative hypoalbuminemia (serum Alb <3.5 g/dL). The association between hypoalbuminemia and clinical characteristics and outcomes including postoperative complications, ventilator duration, and length of hospital stay was assessed.

Preoperative hypoalbuminemia was observed in 38 (19%) patients. Patients with hypoalbuminemia had higher postoperative complications including hemorrhage, infection, cardiac arrest, AKI, and in-hospital mortality than patients with normal albumin levels (84.2% vs. 13%, P<0.0001). Ventilator duration, length of hospital stay and ICU were significantly longer in hypoalbuminemia patients than normal albumin group (P<0.0001). Preoperative hypoalbuminemia (P<0.0001), ventilator duration (P=0.025), and length of hospital stay (P=0.002) were independent predictors of CABG postoperative complications.

Preoperative hypoalbuminemia was associated with postoperative mortality and complications, including hemorrhage, infection, stroke, and AKI development in patients undergoing CABG procedure. Thus, serum albumin measurement before CABG as a clinically implementable and easy method could be used for management and prevention of postoperative complications.

Long noncoding RNAs (lncRNAs) are lengthy noncoding transcripts which are actively involved in crucial cellular pathways. Tissue-specific expression of lncRNAs beside their secretion into the body fluids, have made lncRNAs in attention as biomarkers of the diseases. According to the role of lncRNAs, especially H19 in cardiac regeneration, it is not surprising if their altered expression levels lead to cardiac diseases. In the present study, the relative expression of H19 was compared in the plasma of atherosclerotic myocardial infarction and control individuals by real time- PCR, and data were normalized using GAPDH. The association of plasma level of lipid and homocystine with H19 expression was also considered. The potential of H19 to discriminate the case from control was studied using the ROC analysis. We found that plasma level of H19 transcript was significantly increased in the plasma of patients in comparison with the control group. Additionally, the relative expression level of H19 was directly associated with the plasma homocystine level. The relative expression of H19 at threshold of 0.3 showed 70% sensitivity and 94% specificity to discriminate cases from controls. This study revealed that the expression level of H19 may be considered as a biomarker of myocardial infarction although further studies are needed to generalize this finding.

Coronary artery disease (CAD) is the major cause of deaths and injuries in the world, including Iran and higher percentage of deaths occur in young people. The purpose of this study was to evaluate the prevalence of coronary artery disease in the past decade among young people referring to angiography department of Golestan hospital, Ahvaz. Subjects and This cross-sectional epidemiological study was based on data collected from patients records admitted for elective angiography Ahvaz Golestan Hospital from 2001 to 2011. The patients were divided into 5 age groups. Each group was allocated according to CAD severity, normal, minimal, one, two and three stenosised vessels. Severity of coronary artery disease in each age group were compared ten years later. The overall CAD prevalence in all age groups was 65.3% in 2011 and 67.6% in 2001 (P<0.54). Prevlance of CAD in patients equal and younger than 45 yr was 52.45% in 2001 and 42.2% in 2011 (P< 0.29). In 2001, the % of CAD in patients aged 45-50, 50-55, 55-60 and > 60 yr patients who had CAD was 68.1, 66.6, 71.1, and 79.4 % respectively. While, the prevalence among the same age group in 2011 was 56.25, 60, 69.5 and 83.3.respectivley (all P>0.05). The overall prevalence of coronary artery disease among different age groups did not change significantly over time. It seems that there is no significant change in frequency of CAD between 2001 and 2011 years

This study defines the relationship between salivary beta-2 microglobulin (ß2-M) and intensity of uremia in male patients diagnosed with chronic renal failure (CRF). In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine ß2-M, blood urea nitrogen (BUN) and creatinine (Cr) levels. There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).The correlation between serum and salivary Cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. The correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. The correlation between serum BUN and ß2-M was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. The correlation between serum Cr and ß2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. The correlation between serum BUN and salivary ß2-M was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. The correlation between serum Cr and salivary ß2-M was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group. The results of the study indicated that salivary ß2-M cannot be used as a non-invasive indicator to detect the severity of renal failure.