فهرست مطالب mobina fathi

Approximately 8% of breast cancers originate within the central ducts near the nipple-areolar complex(NAC), which has revealed higher rates of occult involvement than previously thought. Precise preoperative imaging to assess NAC and subjacent tumor involvement has become critical to identify candidates for nipple-sparing mastectomy (NSM) while ensuring oncological safety. The aim of our study is to determine whether Magnetic Resonance Imaging (MRI) could be used for the detection of subtle neoplastic infiltration.

Electronic databases including PubMed, Scopus, Web of Science, and EMBASE were systematically searched to identify all relevant studies published before 2024 on diagnostic performance of MRI in malignant extension to the nipple. The keywords included MRI, NAC, breast cancer, NSM, True Positive (TP), True Negative (TN), False Positive (FP), False Negative (FN) were extracted for analysis. Finally, 5 articles were selected for our meta-analysis. STATA version 15 was used to analysis data.

Our meta-analysis showed a pooled sensitivity of 85%(95% CI: 77%-91%)with low heterogeneity(I2 = 00.00%), and a pooled specificity of 82% (95% CI: 49%- 95%), with significant heterogeneity(I2 = 98%). The pooled positive diagnostic likelihood ratio(pDLR) was 4.6(95% CI: 1.3-16.6, I2 = 96.66%), and the negative diagnostic likelihood ratio(nDLR) was 0.18(95% CI: 0.10-0.33, I2 = 50.06%).

Diagnostic MRI characteristics such as NAC enhancement, non-mass enhancement (NME) type, mass size (greater than 20 mm), and tumor-to-nipple distance (TND) were assocaited with the presence of NAC involement. Because of high diagnostic accuracy, MRI imaging can be used as a helpful tool for NAC diagnosis.

 Social capital, by encouraging people to collaborate and engage in social interactions, has been considered as an effective factor for development of mental disorders. In the preset study, we aimed to investigate the relationship between different aspects of social capital and psychiatric disorders in children and adolescents.

 This study was conducted between 2016 and 2017 in Kohgiloyeh and Boyer-Ahmad province, Iran. A total of 1001 children and adolescents aged 6-18 years and their parents were randomly selected using multistage cluster sampling to participate in the study. The data in the present study were compiled using a Persian translated version of the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) semi-structured questionnaire as well as the Social Capital Questionnaire of Nahapiet and Ghoshal. The raw data were analyzed statistically using Fisher and chi-square tests. The statistical analysis was performed using SPSS 16.0 version.

 Our results show that better relationship, cooperation, mutual understanding, and commitment are significantly and inversely correlated to psychiatric disorders among children and adolescents. In this regard we found that the mutual understanding (P=0.008) and relationships (P=0.001) are strongly related to social capital, while other components may have more or less effects.

 Our findings show that various aspects of social capital are associated with development of psychiatric disorders in children and adolescents. Some of the social capital components including better relationship, cooperation, mutual understanding, and obligation have significant effects; however, others including networks, values and trust could not exert significant effects on mental health.

With the widespread application of ionizing radiation in medical practice, concerns have been increased regarding the hazardous effects of radiation. Studies have demonstrated that some variables such as body dimensions affect the absorbed radiation dose. In this study, the association between Body Mass Index (BMI) and absorbed dose in Computed Tomography (CT) is investigated.

A total of 550 adult patients (age ≥ 15 years) were included in the study. The height and weight of the patients were recorded for BMI calculation. Dosimetry data were acquired from digital imaging and communications in medicine dose reports. The patients were categorized into five groups according to their BMI, the categorized information was then imported into ImPACT Dose software for calculation of Size-Specific Dose Estimate (SSDE) and organ and effective doses. The relationship between patient BMI and the effective dose was also determined.

A higher BMI contributed to increased radiation dose and SSDE in patients who had undergone chest or abdomen-pelvis CT examination (p < 0.05). 

The radiation dose is related to a patient’s BMI and rises with an increase in BMI. Accordingly, it is suggested that BMI and other variables, such as the type of scan and other body dimensions, which affect the radiation dose, can be used to estimate the radiation dose before performing CT. This estimation can be considered for the justification and optimization of CT examinations.

 Given the growing rate of psychiatric disorders, especially in young populations, detailed data on frequency of these disorders for further national public health strategiesis of great importance.We aimed to survey the frequency of different psychiatric disorders among children and adolescents in Kohgiloyeh and Boyer-Ahmad province.

 1001 cases were selected using the random cluster sampling method and all cases were interviewed by expert psychologists using a Persian version of semi- structured K-SADS-PL questionnaire. Data were then statistically analyzed by SPSS software.

 20.5% (205 out of 1001) of studied cases showed at least one psychiatric disorder and 79.5 % showed no sign of any disorders. Anxiety disorders were the most frequent disorders  (15.5%) followed by the behavioral disorders (7%), smoking and drug abuse (6%), behavioral disorders (2.4%) and neurodevelopmental disorders (2%), but no case was observed with psychosis.

 in comparison with other studies from Iran or other countries the prevalence of psychiatric disorders in Kohgiloyeh and Boyer-Ahmad is relatively high and special policies and efforts are suggested for enhancement of mental health values in this region.

For the last three decades, the world population has experienced new epidemics of coronaviruses. The world is currently witnessing the novel coronavirus disease (COVID-19) epidemic, which is a disease that comes from a novel coronavirus called Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The available genetic and clinical proofs suggest a similar route to those of Middle East respiratory syndrome (MERS) and SARS. The clinical manifestations of infections caused by coronaviruses including SARS, MERS, and COVID-19 are pneumonia, bronchitis, or other serious respiratory infections. Various transmission ways (e.g., nosocomial transmission) and transmission through moderately symptomatic or non-symptomatic infected individuals have caused great concerns. Although no certain treatment has so far been developed for this disease, and prevention is the main applied strategy for these viruses, some medications can be used to help with this disease. Corticosteroids can be mentioned as an example of these medications. This article specifically reviewed the evidence regarding the effectiveness of the corticosteroid therapy for the coronavirus family (i.e., SARS, MERS, and COVID-19) and showed that there are insufficient data to recommend corticosteroid therapy for patients suffering from COVID-19.

 Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women.

 The aim of this study was to evaluate the in vitro antifungal susceptibility of clinical isolates Candida albicans and Candida glabrata, the two most common candida species in Iranian patients with VVC.

 One hundred and eight clinical isolates of candida, including; C. albicans (n = 77) and C. glabrata: (n = 31) were isolated from the 108 patients with VVC. The in vitro activity of caspofungin (CAS), amphotericin B (AMB), voriconazole (VRC), itraconazole (ITC), fluconazole (FLC), and nystatin (NYS) were determined according to the CLSI M27-A3 and CLSI M27-S4.

 Our results were shown 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4%, and 3.7% of all isolates, and six isolates (5.6%) had intermediate MIC to CAS.

 We reported 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4% and 3.7% of all isolates, respectively.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new global health threat.

To analyze the effectiveness of the measurement of specific antibodies to SARS-CoV2 (IgM and IgG) for the diagnosis of COVID-19 and to analyze the rate of SARS-CoV2 seroprevalence in the population.

11 relevant studies, published before June 5, 2020, were included in this meta-analysis. These studies were identified by searching the MEDLINE and Scopus databases. The final selected studies were analyzed using STATA version 14. Publication bias was examined using both Egger's test and Funnel plots. Moreover, the I² statistic has been used to evaluate and verify heterogeneity.

The 11 relevant studies selected for the present meta-analysis cover a total of 996 infection cases. According to the results, the average rate of positive cases for IgM (AU/mL) was 2.10 (95% CI: 1.65-2.55; I2=92.2%), and the sensitivity in individuals with positive IgM test was 63% (95% CI: 47-79; I2=94.9%). In addition, the average rate of positive cases for IgG (AU/mL) was 67.44 (95% CI: 28.79-106.09; I2=99.4%), and the sensitivity in individuals with positive IgG test was 79% (95% CI: 67-90; I2=89.5%).

According to this analysis, detection of anti-SARS-CoV-2 IgM and IgG antibodies may assist early detection of SARS-CoV2 infection. Whether antibodies against SARS-CoV-2 confer protective immunity warrants further studies.

Since the emergence in December 2019, the novel coronavirus disease 2019 (COVID-19) has caused a global pandemic that has infected so many people all around the world. As there are no vaccination or antiviral treatment available yet, public health measuresplay a substantial role in the management of this pandemic. Governments of affected countries have imposed different quarantine policies and travel bans. As quarantine can have many controversial aspects, this review intends to clarify its role in diseasecontrol and other aspects of human everyday life with due attention to a couple of epidemics in the past (SARS, MERS, and flu) and ongoing COVID-19 outbreak.

We conducted a thorough search in PubMed, Research Gate, Google Scholar, Excerpta Media Database (EMBASE), and Web of Science databases and collected all relevant articles to Quarantine in the past epidemics (SARS, MERS, and flu) as well as ongoing COVID-19 pandemic.

A total of 176articles were extracted in our primary search process. Primarily, 53 articles have been excluded because of duplication. The other 44 articles have been excluded due to different reasons (Lack of usefulinformationand eligibility of data). Finally, 79articles were selected for more evaluation(published untilApril 2020).

By having previous epidemics, including SARS, MERS, and flu, in mind, quarantine and isolation seem to be proper choices for this situation. But, as this epidemyis bigger than former ones, stricter public health measurements, such as serious social distancing and community-wide containment, are recommended.