فهرست مطالب mohamadhossein assi

The aim of this study was to investigate the relationship between congenital heart disease in fetal echocardiography with high NT size in fetal ultrasound in mothers referring to Hazrat Masoumeh Hospital in 2019.

In this analytical study, information of all pregnant women who underwent ultrasound screening in the first trimester of pregnancy and their NT size was determined, as well as information from fetal echocardiographic results in the next stage. Fetal echocardiography was extracted from the files and then the relationship between cardiovascular abnormalities with NT size and variables such as birth, weight, gestational age and sex in these mothers were checked and examined. Finally, the relationship between congenital heart defects and NT size was investigated using t-test.

The mean size of NT in 152 neonates without cardiovascular disease was 1.67. 0.3 and this value was 0.5 ± 1.86 mm in 40 neonates with cardiovascular disease. Also, a statistically significant relationship was found between NT size and cardiovascular disease in neonates (P = 0.00). There was also a statistically significant relationship between neonatal gender (P = 0.71), maternal age (P = 0.88), between number of pregnancies (P = 0.26), NT size (P = 0.76), type of pregnancy (P = 0.63), gestational age (P = 0.4), and NT size was not found on ultrasound.

Fetal echocardiography is a non-invasive method for early detection of congenital heart disease that is suitable not only in high-risk pregnancies but also in low-risk pregnancies. Increased NT size is also associated with cardiovascular disease in infants.

Treatment of hyperlipidemia, as a major risk factor of cardiovascular disease with the leading role in atherosclerosis and cardiovascular adverse effect, is now a medical dilemma worldwide. Notwithstanding the comprehensive knowledge about the impact of this factor on cardiovascular system, successful achievement of therapeutic goals of medical therapy still remains an unattained desire. The aim of this study is to evaluate the underlying causes apart from medication itself.

This study was performed cross-sectional. In this study, which was conducted for 6 months from March 2016, 50 patients were fully evaluated and followed up. Inclusion criteria for patients with acute myocardial infarction were newly diagnosed when the first full dose of statin (Atorvastatin 80 mg) was started for them. Exclusion criteria were history of taking fat-reducing drugs before the study. Predetermined data extraction forms including medical and laboratory variables and the Multidimensional Scale of Perceived Social Support Questionnaire (MSPSS) were completed for all patients at the first visit and after 6 months. Data were analyzed using SPSS software.

Among 50 patients completely reviewed, 28 were men (56%) and 22 were women (44%) (P˃ 0.05), with the mean age of 60 (±10.19) years old. Only 20 patients (40%) could achieve therapeutic goal of LDL-c (˃ 70 mg/dl). Irregular drug consumption was the only factor significantly differed between patients who achieved the goals and those could not achieve (P= 0.034). Subgroup analysis among patients with regular and irregular drug consumption demonstrate that low educational level along with poor socio-economic support were significantly differed between these patients (P˃ 0.05).

There are some conditions independently influence the efficacy of a medical treatment to improve hyperlipidemia including educational and socio-economic determinants, apart from issues related to medication itself. Therefore, patient’s lifestyle and their condition have to be considered in planning a medical therapy.