فهرست مطالب n .naghsh

Magnesium oxide nanoparticles are characterized with a wide variety of applications and are massproduced throughout the world. However, questions remain regarding their safety. In this study, the hepatoprotective effects of fig and olive hydroethanolic extract in Quranic ratios of 1: 7 in the prevention of thioacetamide-induced liver damage in male Syrian mice were investigated. In addition, hematology, biochemistry, and histopathology of the rats are examined at various concentrations (75,150,300 mg / kg) over 28-days period. In this experimental study, 36 male rats were divided into 6 groups of 6. Control without any drug treatment, the control group treated with thioacetamide 100 mg / kg, the third group treated with 300 mg / kg metformin, and groups 4, 5 and 6 with coated concentrations of 75,150,300 mg / kg, were gavaged every other day for 28 days. At the end of the experiment and the mean activity of ALT, AST and ALP enzymes was compared with the control group. The results of one-way analysis of variance (ANOVA) showed a significant increase in serum SGOT level in thioacetamide + metformin and thiostamide groups compared to other groups (P <0.001). Thioacetamide + metformin and thioacetamide were seen compared to other groups (P <0.001). A significant increase in ALP enzyme activity was observed in all groups compared to the control group receiving 150mg / kg coated nanoparticles (P <0.01). The combination of hydroathanolic extract of fig and olive fruit with Quranic ratios may modulate liver enzymes.

There are many promising advances in biological detection and the use of nanostructures and multifunction devices. The Qur'an also mentions foods that undoubtedly paying attention to them and applying the instructions given about them can ensure physical and mental health. In this study, the protective effects of liver hydroathanolic extract of fig and olive in Quranic ratios of 1: 7 in the prevention of thioacetamide-induced liver damage in male mice were investigated.

In this study, doses of 75, 150 and 300 mg/kg MgO@FO were injected into one-month-old male mice. Chemical precipitation method was used to synthesize MgO (2 to 3 nm) and MgO@FO quantum dots. Their physical properties were evaluated by X-ray diffraction (XRD), visible ultraviolet (UV) spectroscopy and transmission electron microscopy (TEM).

Histological studies of liver tissue in the group treated with plant extracts and nanoparticles. The nanoparticles coated with hydroethanolic extract of fig and olive oil had the least damage and bleeding compared to the group receiving thioacetamide at a concentration of 100 kg/mg. It was shown that the obtained MgO@FO quantum dots have a high hexagonal crystal structure.

The combination of hydroethanolic extract of fig and olive fruit with Quranic ratios may protect the liver tissue probably by increasing the activity of antioxidant compounds in the above extract and thus reducing oxidative stress and lipid peroxidation caused by thivastamide.

Carotenoids have received much attention due to their conversion to vitamin A in the body, reducing the risk of destructive diseases, antioxidant activity, improving immune function and their application as edible colors.

In this quasi-experimental study conducted in 2018, 24 male albino mice were included in the study and randomly divided into 3 groups of 8. The two groups received 32 mg/kg and 16 mg/kg carotenoids peritoneally. The control group received 0.5 ml of distilled water intraperitoneally, then blood sampling was performed and liver health in mice was assessed by measuring the GGT, ALP, SGOT and SGPT factors. The obtained results were analyzed using analysis of variance and Anova statistical tests in SPSS21 software.

In this study, the amount of carotenoids isolated from the yeast of Rhodoturola glutenis was equal to 0.1 mg/L and the results of the related food industry with a purity of: 12.21 mg%, moisture content of 18 mg/L, ash. Total: 9.6 mg percent, volatiles: 9.8 mg percent, acid number 7.3 mg percent and pH: 5.5 was stated. The mean activity of SGOT, SGPT, ALP in the 32 and 16mg/kg injections was not significantly different with the control group. But the mean of GGT activity in the 32mg/kg treated group was significantly less than the 16mg/kg injection group.

According to the results of this study, Rhodotorula glutinis carotenoids was not significantly different in liver enzyme activity in treatment and control group. But, the GGT activity is an important marker of oxidative stress. The mean of GGT activity in the 32mg/kg injection group was significantly less than other group. On the other hand, gammaglutamyl transferase is one of the markers of oxidative stress. Due to the inverse activity of GGT and its antioxidant properties, the reason for the decrease in the activity of this enzyme in the injected group at a dose of 32 mg / kg carotenoid is probably the dose-dependent antioxidant effects of most carotenoids. So, it is recommended to use it as a supplement in the food industry.

In recent years، the resistance of opportunistic fungal strains to commercially available antifungal agents has been increased. The serious side effects of these compounds on mammalian cells forced the researchers to search for new antifungal substances. Thus we decided to investigate the antifungal properties of silver nanoparticles against Aspergillusfumigatus.

To investigate the antifungal effect of the round silver nanoparticles with 10nm diameter against Aspergillusfumigatus، the diameter of colonies after 8 days as well as the number of colonies in different days was determined، using direct drop test. After that، to measure the Minimum Inhibitory Concentration (MIC) and Minimum Fungicide Concentration (MFC) values of silver nanoparticles and fluconazole، Micro Dilution Broth method was performed. At the end، the MIC and MFC values of silver nanoparticles were compared to MIC and MFC of fluconazole.

The results obtained from direct drop test confirm that the silver nanoparticles can decrease the diameter of fungal colonies in dose dependent manner. The data of silver nanoparticles on the number of colonies in different days shows that the number of colonies increases up to sixth day and then becomes fixed. Based on the results of Micro Dilution Broth method، the MIC and the MFC values of this component are 31. 25 and 62. 5ppm، respectively.

The present study confirms that silver nanoparticles with 10nm diameter have antifungal activity against Aspergillus fumigates.