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Given that the Single Photon Emission Computed Tomography (SPECT) image quality is defined experimentally, developing a specialized scanning technique for each procedure is necessary to increase the diagnosis accuracy. This study aims to determine the optimal algorithm for liver scan reconstruction using 99mTc/SPECT.

The Filtered Back-Projection (FBP) reconstruction method was used in liver scanning using 99mTc-EDDA/HYNIC-TOC (Tektrotyd) for SPECT images of 30 patients which were acquired with a dual-head EvoExel detector system. Using different types of filters in SPECT imaging, various optimal results can be achieved in the processed images, such as artifact reduction, noise reduction, or signal enhancement and recovery. To evaluate the effect of different filters on image quality, Signal-to-Noise-Ratio (SNR), Contrast-to-Noise-Ratio (CNR), and contrast parameters were calculated.

Applying filters enhanced contrast in the images in most cases as well as CNR and SNR. Metz (power = 2), Shepp-Logan (Cut-off frequency = 0.67) and Metz (power = 2) filters increase the CNR, contrast and SNR in images more than the other filters, respectively. The maximum improvement for CNR, contrast and SNR was from 0.62 to 2.35, 0.99 to 1.31, and 8.48 to 14.70, respectively.

Based on the results, the Hamming filter, due to providing high-quality images for visual analysis of liver SPECT, and the Butterworth filter, due to balancing the image quality and noise for quantitative analysis, are recommended.