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nafiseh pourbadakhshan

  • Mohsen Reza, Bahareh Imani, Mahboubeh Dordipour, Nafiseh Pourbadakhshan *
    Background
    Fetal Malnutrition (FM) is caused by inadequate formation of fat, subcutaneous tissues and muscle mass in the fetus, which is associated with several morbidities. Thus, accurate and timely diagnosis of FM is crucial in newborns. In this study, we aimed to compare the nutritional status (Fetal Malnutrition) of a newborn in Ghaem Hospital, Mashhad University of Medical Sciences, Iran, based on CANSCORE with anthropometric criteria.
    Methods
    In this cross-sectional descriptive study, 367 neonates who were born from 2020 to 2021 in the maternity ward of Ghaem Hospital, Mashhad were evaluated in the first 24 to 48 hours of life. Demographic characteristics, anthropometric criteria and CANSCORE of neonates were recorded and analyzed using SPSS software (version 16). A p-value <0.05 was considered statistically significant.
    Results
    367 neonates (54.8% females), with a mean gestational age of 38.7 ± 1.4 weeks, were studied. Mean anthropometric indices, including height, mid-arm circumference and head circumference were 50.05 ± 2.3 cm, 10.5 ± 1.1 cm, and 34.8 ± 1.5 cm, respectively. Average CANSCORE was 25.5 ± 1.9. The majority of the neonates were AGA (89.6%), while 6% were SGA. According to MAC/HC, BMI, and PI, 0%, 14.4% and 12.3% of newborns were malnourished, respectively. CANSCORE identified FM in 19.1% of neonates. A significant correlation between neonates’ weight (SGA, AGA, LGA) and CANSCORE was detected (p<0.001). Bivariate analysis with Pearson’s correlation showed a significant and positive relationship between all anthropometric indices and CANSCORE (p<0.05).
    Conclusion
    CANSCORE is an accurate clinical tool for identifying FM in term newborns.
    Keywords: Fetal Malnourishment, Neonate, Malnourishment, CANSCORE
  • Mahdieh Vahedi, Abdolreza Malek, Sara Saadat, Fatemeh Tahghighi Sharabian, Nafiseh Pourbadakhshan *

    Since the beginning of the COVID-19 pandemic, vaccination has been crucial in reducing deaths and hospitalizations. However, vaccination may trigger autoimmune responses. We present the first case of new-onset systemic lupus erythematosus in a 12-year-old girl, three weeks after receiving the first dose of Sinopharm BIBP COVID-19 vaccine. Complications of COVID-19 vaccines are typically mild. There have been reports of a potential association between the vaccines and autoimmune disorders. However, severe events are rare. Vaccination for COVID-19 is recommended even for those with a genetic predisposition to autoimmune disease, as the advantages of preventing COVID-19 outweigh the potential risks of acquiring autoimmune diseases.

    Keywords: COVID-19, Vaccine, Autoimmune Diseases, Systemic Lupus Erythematosus
  • Neda Alimohammadi, Mohammadhassan Aelami *, Nafiseh Pourbadakhshan, Saeid Amel Jamehdar, Majid Khadem-Rezaiyan, Samira Asli
    Background

    Viral agents are the most common pathogens that can infect children between the ages of two and five. Although previous studies worldwide have investigated the viral causes of lower respiratory infections before the pandemic, researchers focused on the coronavirus with the increase in respiratory infections during the pandemic. However, it became evident that other viruses should also be monitored.

    Objectives

    We aimed to detect viruses in cases of pneumonia and bronchiolitis in children over 2 months old during the COVID-19 emergency in Mashhad.

    Methods

    All hospitalized children admitted to Akbar Hospital, Mashhad, Iran, from January 2021 to January 2022, with a final evidence-based diagnosis of pneumonia or bronchiolitis by an expert pediatrician were included. Convenient nasopharyngeal samples were taken and analyzed with multiplex polymerase chain reaction (PCR). Moreover, patients’ on-admission presentations were recorded. Data were reported using descriptive statistics and analyzed with IBM SPSS software.

    Results

    We assessed 102 children with an average age of 3.80 ± 3.40 years who were admitted with pneumonia (N = 97) and bronchiolitis (N = 5). COVID-19 and respiratory syncytial virus (RSV) were the most frequent viruses in pneumonia and bronchiolitis patients, respectively. The most common symptom was cough, occurring in over 90% of the study population. Wheezing was heard in 4 out of 5 bronchiolitis cases, while crackles were more frequent in pneumonia patients (36.1%). The pulse and respiratory rates of children with bronchiolitis were significantly higher than those with pneumonia (P < 0.05). Results showed that monocyte counts were significantly different between the groups, with higher counts in bronchiolitis patients.

    Conclusions

    The study provided valuable insights into the clinical and laboratory characteristics of pneumonia and bronchiolitis in children, including viral etiology, symptoms, clinical signs, vital signs, and laboratory findings. These findings can aid healthcare professionals in diagnosing and managing these common respiratory infections in hospitalized children. Notably, more accurate follow-up is suggested, especially for viral coinfections that might cause higher rates of morbidity and mortality in children. The study provided valuable insights into the clinical and laboratory characteristics of pneumonia and bronchiolitis in children, including viral etiology, symptoms, clinical signs, vital signs, and laboratory findings. These findings can aid healthcare professionals in diagnosing and managing these common respiratory infections in hospitalized children. Notably, more accurate follow-up is suggested, especially for viral coinfections that might cause higher rates of morbidity and mortality in children.

    Keywords: Pneumonia, Acute Bronchiolitis, COVID-19, Virus, Respiratory Syncytial Virus (RSV), Pediatrics
  • Hadi Mazloum, Naghmeh Razaghi*, Hamidreza Behnam Vashani, Nafiseh Pourbadakhshan
    Introduction

    The performance of invasive methods, such as urinary catheterization in children, usually creates emotional distress in their parents. It is necessary to use appropriate interventions to reduce the anxiety of mothers and hospitalized children.

    Objective

    The present study aimed to investigate the effect of the animation display of urinary catheterization on the anxiety of mothers with hospitalized children in 2021.

    Materials and Methods

    This quasi-experimental study was conducted on 60 mothers (30 mothers in each group) of children aged 1 month to 12 years in the emergency ward of one of the children’s teaching hospitals affiliated with Mashhad University of Medical Sciences, Mashhad City, Iran. They were selected by convenience sampling. Mothers were grouped into intervention and control by random allocation. In the first stage, animation videos on inserting a urinary catheter were prepared separately for male and female children. In the second stage, in the intervention group, mothers watched the animation related to the procedure before the urinary catheter insertion. In the control group, the mothers of hospitalized children were provided face-to-face explanations about the method before urinary catheterization. The Spielberger state-trait anxiety inventory was completed before and after the intervention for both control and intervention groups. The obtained data were analyzed using descriptive (Mean±SD) and inferential (the independent t-test and chi-square test) statistics.

    Results

    The Mean±SD ages of mothers in the intervention and control groups were 36.9±10.87 and 34.44±9.27, and the mean ages of the children in these two groups were 3.5±6.29 and 2.89±6.73 years, respectively. The results of the present study demonstrated no statistically significant difference between the two groups in the mean anxiety score of mothers before watching the animation video. Nonetheless, after watching that animation, there was a significant difference between the two groups (P=0.001), and watching the animation video of urinary catheterization significantly reduced mothers’ anxiety.

    Conclusion

    The present study pointed out that educational animation videos of urinary catheterization reduce mothers’ anxiety levels. It seems that the use of educational animation as an effective, quick, accessible, and easy intervention can be helpful in the reduction of anxiety and enhancement of knowledge among mothers of hospitalized children.

    Keywords: Animation, Urinary Catheter, Anxiety, Mothers, Child
  • Ashraf Mohammadzadeh *, Ahmad Shah Farhat, Ezzat Khodashenas, Jalil Tavakol Afshari, Nafiseh Pourbadakhshan, Mehdi Sohrabi
    Background

    The study aimed to determine the effect of zinc consumption on cell immunity in healthy 6-year-old children. In a double-blind clinical trial after the license of parents, 40 children 6-7 years old were enrolled. The male healthy and 6-7-year-old children were included and those with chronic disease, failure to thrive, and usage of another zinc supplement in the past two months, were excluded. In the case group (N=20), twenty mg of zinc sulfate syrup has been prescribed orally for 6 months. The control group (N=20) received a placebo the same as the case group in the volume, color, bottle size, and shape. Serum zinc level and cellular proliferation were measured before intervention and 12 hours after the last dose of zinc sulfate. Zinc serum was measured by manual colorimetric method technique. A zinc level of less than 65 ug/dl is considered zinc deficiency. The lymphocyte proliferation before and after zinc treatments have been compared by paired T-test analysis.

    Results

    The mean weight of children in the case and control group were 20.37±2.21kg and 20.92±1.98 kg respectively (P= >0.05). Serum zinc level was within the normal limit and did not differ between the two groups before and after intervention (P=0.86). After 6 months of supplementation of 20 mg zinc sulfate per day for 6 months, there were no significant improvements in Lymphocyte proliferation (with/without PHA).

    Conclusion

    This study indicates that moderate supplementation of zinc for six months cannot efficiently improve Lymphocyte proliferation (with/without PHA) in healthy male children.

    Keywords: Zinc Consumption, Cell Immunity, Children
  • Mahboubeh Dordipour, Mohammad Hasan Aelami, Mohsan Raza, Seyyed Parham Ahmadi, Mehran Mansouri, Arsha Khaleghi, Yousof Hajipour, Fatemeh Pelian, Nafiseh Pourbadakhshan *
    Background
    The COVID-19 pandemic presents a major risk to Health Care Workers (HCWs), which necessitates protective strategies. Personal Protective Equipment (PPE) and Hand Hygiene (HH) could prevent COVID-19 infections in healthcare facilities. Our study aimed to determine the level of PPE proper use among HCWs of Mashhad educational hospitals as well as their level of HH.
    Methods
    This cross-sectional study was conducted from January 1st, 2021 to January 1st, 2022 in three educational hospitals in Mashhad. A standard checklist was arranged based on the WHO guidelines and was filled out by the supervisors. Data were analyzed using SPSS v23.0.
    Results
    The total HCWs included in this study were 246, including 154 women. The majority of the participating staff were nurses 135 (54.9%). The most common PPE was the N95 mask (71.1%). One hundred and eighty-four people (46.3%) washed their hands through the standard method, and there was no significant difference between men and women. Also, the level of correct PPEs donning and doffing was 42.2% and 28.4%; respectively. PPE donning was not significantly different between men and women. However, we found a significant difference in doffing PPE.
    Conclusion
    It became evident that HCWs paid moderate attention to PPE and HH, demanding HCWs training to prevent infectious diseases such as the COVID-19.
    Keywords: COVID-19, Personal Protection Equipment, Hand Hygiene, Health Care Workers
  • Ashraf Mohammadzadeh *, Ezzat Khodashenas, Ahmad Shah Farhat, Nafiseh Pourbadakhshan, Ali Jafarzadeh Esfehani, Mehdi Sohrabi, Aradokht Vaezi
    Introduction
    Zinc has a key role in reproductive physiology, immune modulation, growth, and development. To determine the effect of zinc supplements on the anthropometry of healthy 6-yearold children.
    Methods
    In this double-blind placebo-controlled trial was carried out on 40 children 6-7 years old. The intervention group (n=20) received 20mg of oral zinc sulfate syrup and the control group (n=20) received a placebo daily in the same buttle and same test for 6 months duration of study. Serum zinc levels and anthropometric measurements (weight, height, head circumference, and arm circumference) were measured before and after intervention. Zinc deficiency was defined as serum zinc level < 9.9 μmol/l.
    Results
    Serum zinc level did not differ between the two groups (P=0.86). Zinc supplementation resulted in a significant increase in height (P= 0.008).
    Conclusion
    This study showed that zinc supplements have a significant increase in the length of male 6-year-old children.
    Keywords: Children, Zinc, growth
  • عبدالرضا ملک*، مهدیه واحدی، نفیسه پوربدخشان
    زمینه و هدف

    واسکولیت ها یک گروه هتروژن از بیماری ها هستند که به معنای یک روند التهابی در رگ های خونی می باشد. تشخیص واسکولیت ها در کودکان به علت تنوع در علایم امری چالش برانگیز است. هدف از این مطالعه بررسی اطلاعات اپیدمیولوژیک انواع واسکولیت و علایم بالینی آن در کودکان شرق ایران می باشد

    روش بررسی

    این مطالعه توصیفی-مقطعی سه ساله بر روی تمام بیماران دختر و پسر مبتلا به هر گونه واسکولیت مراجعه کننده به درمانگاه سرپایی و بخش روماتولوژی بیمارستان فوق تخصصی کودکان اکبر از ابتدای مهر 1396 تا پایان شهریور 1399 انجام شده است. انجام این مطالعه براساس اطلاعات به دست آمده از چک لیست (اطلاعات از پرونده بستری و سرپایی و اطلاعات موجود در HIS) بوده است.

    یافته ها

    از 263 کودک، 135 بیمار (33/51%) مبتلا به هنوخ شوین لاین و 100 بیمار (02/38%) مبتلا به کاواساکی بودند. تعداد بیماران بهجت، تاکایاسو و چرگ اشتراوس به ترتیب 20 مورد، سه مورد و دو مورد بود. در بیشتر زیر گروه ها بیماران دختر از بیماران پسر بیشتر بوده است. کمترین و بیشترین سن شروع بیماری به ترتیب مربوط به کاواساکی و تاکایوسو بوده در اکثر زیر گروه ها، بثورات جلدی شایعترین علامت بالینی بوده که شایعترین نوع آن پتشی و پورپورا بوده است.

    نتیجه گیری

    در پژوهش حاضر، شایعترین نوع واسکولیت تشخیص داده شده در کودکان شرق ایران هنوخ شوین لاین و پس از آن کاواساکی گزارش شد که کاملا با شایعترین انواع واسکولیت در دوره بزرگسالی متفاوت بوده و نشان دهنده اهمیت سن در تشخیص نوع واسکولیت است.

    کلید واژگان: اپیدمیولوژی, کودکان, ایران, واسکولیت
    Abdolreza Malek*, Mahdieh Vahedi, Nafiseh Pourbadakhshan
    Background

    Vasculitis is a heterogeneous group of diseases that means an inflammatory process in blood vessels. Diagnosing vasculitis in children is challenging due to the variety of symptoms. Classification of childhood vasculitis is usually based on clinical phenotypes, size of affected vessels (small, medium, or large), and pathology of inflammatory infiltrates. The aim of this study is to investigate the epidemiological information on types of vasculitis and their clinical symptoms in children in eastern Iran.

    Methods

    This 3-year descriptive cross-sectional study was performed on all male and female patients with any vasculitis referred to the outpatient clinic and rheumatology department of Akbar Children's Hospital from the beginning of September 2017 to the end of September 2020. Has been. This study was based on information obtained from the checklist (information from the inpatient and outpatient records and information in the HIS). Checklist information included age, gender, drug history, history of surgery, clinical symptoms in different systems, season of disease onset, etc.

    Results

    Out of 263 children, 135 (51.33%) had Henoch-Schonlein and 100 (38/02%) of them had Kawasaki. The numbers of Behcet, Takayasu and Churg-Strauss patients were 20, three and two, respectively. In most subgroups, female patients were more common than male patients. Kawasaki and Takayasu had the lowest and highest age of onset, respectively. The most common seasons of appearance for Henoch-Schonlein and Kawasaki were autumn and summer respectively. In most subgroups, skin rashes are the most common clinical symptom, with, the most common types being petechiae and purpura.

    Conclusion

    In the present study, the most common type of vasculitis diagnosed in children in eastern Iran was reported by Henoch-Schonlein and Kawasaki respectively, which was completely different from the most common types of vasculitis in adulthood and indicated the importance of age in diagnosing the type of vasculitis. The necessity of clinical suspicion of these two diseases in children with skin rashes, along with matching with other clinical findings, is undeniable.

    Keywords: epidemiology, pediatrics, iran, vasculitis
  • Anahita Alizadeh *, Nafiseh Pourbadakhshan
    Objective
    accidental ingestion of brimonidine can lead to serious adverse effects, especially in young children. We report the case of a 2.5-year-old child who ingested brimonidine ointment and experienced apnea and coma.
    Case Presentation
    The case was a female patient with severe central nervous system depression and apnea as a result of brimonidine ointment ingestion. After administration of oxygen and high doses of naloxone, she improved.
    Conclusion
    Eating the alpha 2 adrenergic compounds is very dangerous for children, and in addition to medical staff, parents should also receive adequate training on this matter.
  • مجید خادم رضاییان، آیلر عوض زاده، رویا وطن خواه، حمیدرضا کیانی فر، نفیسه پوربدخشان*
    سابقه و هدف

    محیط یادگیری یک تعیین کننده رفتاری است و درک دانشجو از محیط در امر یادگیری و آموزش بالینی اهمیت زیادی دارد. از الگوی DREEM به عنوان ابزار تشخیصی برای شناسایی تفاوت محیط واقعی با محیط مطلوب استفاده می شود. هدف این مطالعه، بررسی نظرات فراگیران پزشکی و نیز اساتید آنان در مورد کیفیت محیط یادگیری بالینی است.

    مواد و روش ها

    این پژوهش مقطعی بین سال های 1400 تا 1401 انجام شد و دیدگاه 233 نفر از فراگیران پزشکی (دستیاران، کارورزان و کارآموزان) و اعضای هیات علمی با استفاده از پرسش نامه DREEM در پنج حیطه ادراک دانشجو از یادگیری، استادان، جو آموزشی، توانایی علمی و شرایط اجتماعی خود گردآوری شد. به منظور تحلیل داده ها از نرم افزار آماری 27 SPSS استفاده شد.

    یافته ها

    میانگین نمرات وضعیت آموزش بالینی در بخش های اصلی مرکز آموزشی 07/23 ± 00/120 از حداکثر 200 نمره بود. میانگین نمره حیطه یادگیری 22/7 ±85/26، اساتید بالینی 53/4 ± 49/28، درک از توانایی علمی خود 70/4 ± 06/19، جو محیط آموزشی 37/6 ± 54/29 و درک از شرایط اجتماعی 29/4 ± 06/16 بود. استادیاران و دانشیاران نسبت به کاروزان (P به ترتیب 006/0 و 002/0) و کارآموزان (P به ترتیب 019/0 و 006/0) وضعیت محیط یادگیری بالینی بیمارستان را مطلوب تر دانستند.

    نتیجه گیری

    محیط آموزشی بیمارستان اکبر در تمامی حیطه ها مطلوب ارزیابی شد. این امر نشان دهنده توجه بالای اساتید به اصول طراحی آموزشی و ایجاد فضای آموزشی مناسب است. بااین همه، برای ارتقای بیشتر کیفیت آموزش بالینی، می توان از مدل DREEM برای نظارت و اندازه گیری اصلاح و تغییر در برنامه آموزش بالینی استفاده کرد.

    کلید واژگان: محیط یادگیری بالینی, بیمارستان آموزشی, DREEM
    Majid Khadem-Rezaiyan, Aylor Avazzadeh, Roya Vatankhah, Hamidreza Kianifar, Nafiseh Pourbadakhshan*
    Background and Objective

    The learning environment is a behavioral determinant and the student's understanding of the environment is very important in learning and clinical education. The DREEM model is used as a diagnostic tool to identify the difference between the real environment and the desired environment. The purpose of this study is to investigate the opinions of medical students and their professors about the quality of the clinical learning environment.

    Methods

    This cross-sectional study was done between 2021 and 2022 and the views of 233 medical students (assistants, interns and externs) and faculty members was gathered using the DREEM questionnaire in five areas of student perception of learning, professors, educational atmosphere, scientific ability, and social conditions. SPSS 27 was used to analyze the data.  
     

    Findings

    Mean score of the clinical education status in the main wards of the educational center was 120.00±23.07 of 200 Mean score of students’ perceptions of learning was 26.85±7.22, perceptions of teachers (28.49±4.53), academic self-perception (19.06±4.70), perception of the academic atmosphere (29.54±6.37), and social self-perception (16.06±4.29).Assistant professors and associate professors considered the condition of the clinical learning environment of the hospital more favorable than interns (0.006 and 0.002, respectively) and externs (0.019 and 0.006, respectively).

    Conclusion

    Educational environment of Akbar hospital was evaluated as favorable in all areas. This shows the high attention of professors to the principles of educational design and the creation of appropriate educational space. However, to further improve quality, the DREEM model can be used to monitor and measure modification and change in clinical education program.

    Keywords: Clinical Educational Environment, Educational Hospital, DREEM Model
  • Ashraf Mohammadzadeh, Nafiseh Pourbadakhshan *, Ahmad Shah Farhat, Azin Vaezi
    Introduction
    Gestational diabetes is a multifactorial disease that genetic and environmental factors affect insulin sensitivity. This study was designed with consideration towards the importance of micronutrients in carbohydrate metabolism.
    Methods
    The present case-control study was performed on 100 pregnant women referred to Imam Reza Hospital in Mashhad, Iran. Fifty pregnant women with gestational diabetes as defined by the American Diabetes Association guideline were considered as the case group and 50 non-diabetic pregnant women formed the control group. Maternal demographic information was recorded in the checklist . Serum levels of zinc, copper, selenium and chromium were measured in both groups. After data collection, they were processed with spss16 software.
    Results
    The mean age of diabetic and non-diabetic pregnant mothers was 32.33 ± 5.92 and 26.32 ± 5.38 years respectively, and their mean weight was 82.87 ± 10.81 kg in the case and 73.18 ± 10.6 kg in the control group. Maternal weight and age in the gestational diabetes group were significantly higher. (both p < 0.05). There was a significant difference between the case and control groups in terms of family history of diabetes in first-degree relatives; history of formula fed mothers during infancy, gravid > 3 ,and low gestational age were all more common in women with gestational diabetes (p < 0.05). In contrast to chromium, serum levels of zinc, copper and selenium were higher in the group with gestational diabetes.
    Conclusion
    No significant relation was observed between serum zinc, copper, chromium and selenium levels with gestational diabetes.
    Keywords: Micronutrient, Gestational diabetes, Diabetes
  • Samaneh Kouzegaran, Hamid Ahanchian *, Seyed Ahmad Emami, Neda Ansari, Jamshid Yousefi, Nasrin Moazzen, Nafiseh Pourbadakhshan, Rana Tafrishi, Aida Ansari, Nasrinsadat Motevalli
    Introduction
    Asthma is a very common chronic disease among children. As for its treatment, in recent years there is an increased tendency towards supplemental treatments. Hence, many of these patients are administered complementary and alternative treatments including herbal medicine.
    Methods
    Through a cross-sectional study, we evaluated the common herbal remedies used in asthmatic children referred to the allergy clinic of Sarvar Children’s Hospital in Mashhad. All data related to the patients (i.e., age, sex, and history of all remedies consumed as well as the responsible persons prescribing the pertinent medications) were recorded in a checklist.
    Results
    In this study, 582 asthmatic children with the average age of 77.4±41.7 months were evaluated. The overall herbal remedies usage was 59.8%. There was no significant differences between age groups, sex, or asthma severity and herbal remedy usage. Thirty-seven different herbal remedies were prescribed to the patients, the most common herb was thymes (65.3%) followed by a four-seed herbal mixture (23.6%), Plantago major (12%) and Cydonia oblonga (quince) (10.8%).
    Conclusion
    Limited information is available regarding complementary and alternative medicine in asthmatic children in Iran. The present study showed the high prevalence of herbal medicine usage in asthmatic children in this region. Hence, further studies should determine the clinical benefits of these remedies
    Keywords: Asthma, Children, herbal treatment, Alternative Medicine
  • حسن بسکابادی، نفیسه پوربدخشان، مریم ذاکری حمیدی*
    زمینه و هدف

    بیماری های مادر از جمله دیابت، هایپرتانسیون، پره اکلامپسی، هایپوتیروییدی و صرع در بارداری با عوارض جنینی و نوزادی همراه می باشند. هدف از انجام مطالعه حاضر، مقایسه پیش آگهی نوزادی در بیماری های مادر می باشد.

    روش بررسی

    مطالعه حاضر یک مطالعه مقطعی می باشد که روی 600 نوزاد پره ترم با مادران مبتلا به دیابت، هایپرتانسیون، پره اکلامپسی، هایپوتیروییدی و صرع در بیمارستان قایم (عج) مشهد انجام شده است. این مطالعه از فروردین 1394 تا اردیبهشت 1400 و با روش نمونه گیری در دسترس انجام شده است. ابزار جمع آوری اطلاعات در این مطالعه، چک لیست پژوهشگر ساخت شامل مشخصات نوزادی (سن حاملگی، نمره آپگار دقیقه اول، نمره آپگار دقیقه پنجم) و مادری (نوع زایمان، مراقبت های بارداری، پارگی زودرس کیسه آب) بود. پیش آگهی نوزادی در زمان تولد مورد مقایسه قرار گرفت. تجزیه و تحلیل داده ها با استفاده از آزمون های آماری Kolmogorov-Smirnov و Chi-square انجام شده است.

    یافته ها: 

    نوزادان دارای مادران مبتلا به صرع، کمترین نمره آپگار دقیقه اول و کمترین سن حاملگی و نوزادان دارای مادران مبتلا به دیابت، کمترین نمره آپگار دقیقه پنجم را داشتند. مادران مبتلا به هایپوتیرویید، بیشترین میزان پارگی زودرس کیسه آب و مادران مبتلا به هایپرتانسیون و پره اکلامپسی، بیشترین موارد زایمان سزارین را داشتند.

    نتیجه گیری: 

    بیماری های مادر شامل دیابت، هایپرتانسیون، پره اکلامپسی، هایپوتیروییدی و صرع، پیش آگهی نوزادان را از نظر شدت نارسی، پارگی زودرس کیسه آب، نوع زایمان، نمره آپگار دقیقه اول و نمره آپگار دقیقه پنجم تحت تاثیر قرار می دهد. لذا کنترل و درمان مناسب این موارد از بیماری های مادر ممکن است پیش آگهی نوزادی را بهبود دهد.

    کلید واژگان: نمره آپگار, دیابت, صرع, پارگی زودرس کیسه آب, هایپوتیروییدی, نوزاد, مادر, پره اکلامپسی, پیش آگهی
    Hassan Boskabadi, Nafiseh Pourbadakhshan, Maryam Zakerihamidi*
    Background

    Maternal diseases such as diabetes, hypertension, preeclampsia, hypothyroidism and epilepsy in pregnancy are associated with fetal and neonatal complications. The aim of this study was to compare the prognosis of neonates in maternal diseases.

    Methods

    This study was a cross-sectional study. The present study was performed on 600 preterm infants with mothers with diabetes, hypertension, preeclampsia, hypothyroidism and epilepsy. This study was done in Ghaem Hospital of Mashhad from March 2015 to April 2021 with available sampling. The data collection tool was a researcher-made checklist including infant (gestational age, Apgar score of the first minute, Apgar score of the fifth minute) and maternal (mode of delivery, prenatal care, premature rupture of the membranes) characteristics. Neonatal prognosis was compared at birth. All clinical and diagnostic examinations of newborns were performed by a neonatologist. Neonatal and maternal data in the group of newborns with normal mothers and newborns with maternal diseases were analyzed by Kolmogorov-Smirnov and Chi-square tests. The significance level was considered p≤0.05 in all cases.

    Results

    The results show that 161 newborns (28.90%) had normal mothers, 89 newborns (15.98%) had diabetic mothers, 117 newborns (21.01%) had hypertensive mothers, and 50 newborns (8.98%) had hypothyroid mothers. One hundred tweny newborns (21.72%) had mothers with preeclampsia, 19 newborns (3.41%) had mothers with epilepsy. Newborns with mothers with epilepsy had the lowest Apgar score of the first minute and the lowest gestational age and newborns with mothers with diabetes had the lowest Apgar score of the fifth minute. Mothers with hypothyroidism had the highest rate of premature rupture of the membranes and mothers with hypertension and preeclampsia had the highest incidence of cesarean section.

    Conclusion

    Maternal diseases including diabetes, hypertension, preeclampsia, hypothyroidism and epilepsy affect the prognosis of neonates in terms of the severity of prematurity, premature rupture of the membranes, type of delivery, Apgar scores of the first and fifth minutes. Therefore, proper control and treatment of these diseases may improve neonatal prognosis.

    Keywords: apgar score, diabetes mellitus, epilepsy, fetal membranes premature rupture, hypothyroidism, infant, mothers, pre-eclampsia, prognosis
  • Leila Golnari, Mohammad Hasan Aelami, Amin Saeidinia, Maliheh Dadgarmoghaddam, Nafiseh Pourbadakhshan *
    Background
    During the pandemic of COVID-19, Healthcare Workers (HCWs) have been at the forefront of infection; they could also carry the disease to the others.
    Methods
    In this cross-sectional study, HCWs in five hospitals of Mashhad University of Medical Sciences were included from 20 March to 21 July, 2020. HCWs were divided into two categories of frontline and second-line. The checklist was researcher-made and was on the basis of WHO risk factors regarding COVID-19, MERS and SARS. The participants were analyzed. The participants were asked, via phone call, to answer questions in 3 sections of demographics, probable risk factors, and clinical manifestations. The need for Personal Protective Equipment (PPE) and its availability were also evaluated.
    Results
    From among 534 HCWs included in this study, 197(57.6%) were females; most of them were nurses, and the mean ± SD age was 36.02 ± 8.5 years. Eighteen HCWs were hospitalized due to the severity of disease, most of whom were front-line HCWs. Malaise (78.7%), fever (68.1%) and gastrointestinal symptoms (63.7%) were the most common manifestations in the participants. Smoking (OR=0.078, P=0.001) and underlying diseases (OR=2.19, P=0.025) were known as the factors predicting HCWs hospitalization. Being smoker and participating in intubation procedure were independent predictors of hospitalization in HCWs.
    Conclusion
    Frontline HCWs had a significantly higher risk of COVID-19 infection, as compared to the second-line group. Although adequate supplies of PPE are necessary, they do not completely mitigate high-risk
    Keywords: Healthcare workers (HCWs), COVID-19, Risk Factor
  • Afsane Nazari, Sepideh Bagheri, Zahra Abbasi Shaye, Sara Shirdelzade, Nafiseh Pourbadakhshan, Peyman Eshraghi *
    Background

    Methylmalonic acidemia is a rare autosomal recessive disease in which there is a deficiency of intracellular cobalamin. This study aimed to assess the effectiveness of parenteral hydroxylcobalamin in the treatment of children with methylmalonic acidemia.

    Method

    This is a quasi-experimental study without a control group. The participants included under-18-year-old children with confirmed methylmalonic acidemia. There were only 17 patients with the inclusion criteria, all of whom were included in the study. They received 1mg hydroxylcobalamin injection for 3 or 7 days based on their clinical status. Data was gathered by a demographic questionnaire, along with laboratory tests of urine-MMA, and plasma homocysteine, measured before and after the intervention. Data analyses were performed using SPSS v. 26.

    Results

    The samples included 17 patients, most of whom were males (52.9%). They had various clinical manifestations consisting of hypotonia, seizure, verbal disorders, movement disorders, organomegaly, hematologic disorders, and ophthalmic disorders. The parenteral hydroxylcobalamin had a borderline significant effect on urine-MMA (p=0.05); this seems to be due to the sample shortage and can become strongly significant with sample increase.

    Conclusion

    The results revealed the effectiveness of parenteral hydroxylcobalamin in MMA patients. However, there is no standard guideline to suggest the perfect dose of it to acquire the optimum result; so it is suggested to conduct more clinical trials or cohort studies to be done.

    Keywords: Children, Hydroxylcobalamin, Methyl malonic acidemia
  • حسن بسکابادی، نفیسه پوربدخشان*
    مقدمه

    بیماری های مادر در دوران بارداری، اثرات متعددی بر روی جنین و زندگی پس از تولد آن داشته و از طرفی مشکلات تنفسی و عفونی در نوزادان نارس بسیار شایع است، لذا مطالعه حاضر با هدف مقایسه این دو مشکل شایع در مادران با حاملگی دارای مشکل و نرمال انجام شد.

    روش کار:

     در این مطالعه توصیفی گذشته نگر نوزادان نارس بستری در بخش NICU بیمارستان قایم (عج) مشهد طی سال های 1400-1393 مورد بررسی قرار گرفتند و اطلاعات مربوط به مطالعه شامل اطلاعات مادری (سن مادر، نوع زایمان، بیماری های مادر و عوارض بارداری) و نوزادی (مشکلات تنفسی، کشت خون، شمارش کامل سلولی، CRP و ESR) ثبت گردید. سپس مشخصات نوزادان در دو گروه مادران سالم و مادران مبتلا به بیماری های شایع بارداری با یکدیگر مقایسه شد. تجزیه و تحلیل داده ها با استفاده از نرم افزار آماری SPSS (نسخه 26) و آزمون های تی تست مستقل و کای دو انجام شد. میزان p کمتر از 05/0 معنی دار در نظر گرفته شد.

    یافته ها

    در بررسی 982 مادر و نوزاد، در گروه مادران سالم و مبتلا به بیماری به ترتیب متوسط سن حاملگی  93/31 و 95/30 هفته، بروز سندرم زجر تنفسی در 39 (5/32%) و 357 (9/56%) نوزاد، دیسترس تنفسی غیراختصاصی در 13 (8/7%) و 105 (9/12%) نوزاد، افزایش فشار ریوی اولیه در صفر و 22 (7/2%) نوزاد، سپسیس در 37 (4/22%) و 219 (8/26%) نوزاد و بروز مننژیت در 2 (2/1%) و 15 (8/1%) نوزاد گزارش گردید (001/0>p).

    نتیجه گیری

    نارسی، شدت آن و مشکلات همراه آن در نوزادان مادران همراه با مشکلات دوران بارداری افزایش می یابد و مشکلات تنفسی، عفونی و حمایت تنفسی و مراقبت های لازم نیز بیشتر می گردد.

    کلید واژگان: سپسیس, سندرم دیسترس تنفسی, عوارض حاملگی, مننژیت, نارسی
    Hasan Boskabadi, Nafiseh Pourbadakhshan *
    Introduction

    Maternal diseases during pregnancy have many effects on the fetus and infant, and on the other hand, respiratory and infectious problems are very common in premature neonates, so this study was performed with aim to compare these two common problems in mothers with normal and problematic pregnancies.

    Methods

    In this retrospective descriptive study, the premature neonates hospitalized in the NICU of Ghaem Hospital, Mashhad during 2014-2022 were examined, and the information related to the study, including maternal information (mother's age, type of delivery, maternal diseases  and pregnancy complications) and newborn information (respiratory problems, blood culture, complete blood cell count, C-reactive protein(CRP) and Erythrocyte Sedimentation Rate ( ESR)) were recorded. Then the neonates' characteristics in the two groups of healthy mothers and mothers with common pregnancy diseases were compared. Data were analyzed by SPSS (version 26) and Independent t-test and Chi-square test. P<0.05 was considered statistically significant.

    Results

    From a total of 982 mothers and newborns, mean gestational age in the group of healthy and diseased mothers was 31.93 and 30.95 weeks, the incidence of respiratory distress syndrome was reported in 39 (32.5%) and 357 infants (56.9%), non-specific respiratory distress in 13 (7.8%) and 105 infants (12.9%), primary pulmonary hypertension in 0 and 22 infants (2.7%), sepsis in 37 (22.4%) and 219 infants (26.8%), and the incidence of meningitis in 2 (1.2% ) and 15 infants (1.8%), respectively (P<0.001)

    Conclusion

    Prematurity, its severity and related problems increase in infant of mothers with problems during pregnancy. Respiratory and infectious problem, respiratory support and necessary care also increase.

    Keywords: Meningitis, Pregnancy complications, Prematurity, respiratory distress syndrome, Sepsis
  • Maryam Khalesi, Moammad Ali Kiani, Seyed Ali Jafari, Monireh Yaghoubi, Seyed Hosein Ghavami Shahri, Ali Reza Attaei Nakhaie, Nafiseh Pourbadakhshan *
    Background
    Biliary atresia (BA) is an important etiology of liver disease in pediatric patients which manifests as extrahepatic cholestasis. Alagille criterion is a combination of noninvasive findings for the diagnosis of BA. In this regard, the current retrospective study aimed to evaluate the diagnostic accuracy of Alagille criteria for BA.
    Methods
    This cross-sectional study was conducted in Ghaem Hospital, affiliated to Mashhad University of Medical Sciences during 2009-2014. All infants less than 2 years old with cholestasis referred to the pediatric gastrointestinal ward were included in this study. Alagille criteria were evaluated for each patient, and BA was confirmed with intraoperative cholangiography. Finally, sensitivity, specificity, and positive and negative predictive values of Alagille criteria were determined according to the final diagnosis.
    Results
    In general, 92 patients were included in this study. The male-to-female ratio and the mean age of patients were 54/38 and 42±5 days (ranging between 1 and 5 months), respectively. There was a significant difference between the two groups in terms of gender, onset time of jaundice, and the presence of the acholic stool (P=0.02, 0.04, and 0.005, respectively). Eventually, the acholic stool had the highest sensitivity, specificity, and positive and negative predictive values.
    Conclusion
    Based on the findings, the presence of the acholic stool was the most valuable criterion for the diagnosis of BA among all Alagille criteria.
    Keywords: Alagille criteria, Intrahepatic, cholestasis, Acholic stool
  • حمیدرضا کیانی فر، نسرین موذن، مریم خالصی، نفیسه پوربدخشان*
    مقدمه

    به دنبال پاندمی کووید 19 در اوایل سال 2020 و لزوم رعایت فاصله گذاری اجتماعی، آموزش دانش آموزان و دانشجویان در سطوح مختلف دچار اختلال شد. موسسات آموزشی و دانشگاه ها برای جبران این نقصان از روش های مختلف استفاده کردند که در این میان آموزش الکترونیکی از جایگاه ویژه ای برخوردار شد.

    روش کار

    ما در بیمارستان فوق تخصصی اکبر مشهد از نیمه اسفند ماه 1398 تا انتهای اردیبهشت ماه 1399 یک استودیو مجازی ایجاد نموده که اساتید محترم گروه اطفال دانشگاه علوم پزشکی مشهد دروس تعیین شده جهت کارآموزان و کاروزان و دستیاران را در این استودیو ضبط نمودند. برنامه Healthstudio  که قابلیت های متعددی از جمله ویرایش فیلم به منظور بهبود بخشیدن به کیفیت فیلم های ضبط شده با آن برای ما فراهم بود را راه اندازی نمودیم.

    نتایج

    یک استودیو به عنوان فضایی جهت ضبط به صورت مجازی تجهیز شد که در آن 50 جلسه آموزشی در قالب لینک برای مقطع کارآموزی و 27 جلسه آموزشی برای مقطع کارورزی و 5 جلسه آموزشی برای دستیاران تهیه گردید. لینک ها پس از آماده سازی در سامانه نوید (نرم افزار ویزه یادگیری دانشگاهی) نیز بارگذاری گردیدند.

    نتیجه گیری

    ما تلاش کردیم تا با این اقدامات زیر ساختی مناسب در جهت دسترسی سریع و آسان دانشجویان پزشکی به محتواهای آموزشی فراهم سازیم.

    کلید واژگان: آموزش الکترونیکی, کروناویروس19, کارآموز, کار, ورز
    Hamidreza Kianifar, Nasrin Moazzen, Maryam Khalesi, Nafiseh Pourbadakhshan *
    Introduction

    Following the Covid 19 pandemic in early 2020, the need to observe social distance, education of students at different levels was disrupted. Educational institutions and universities used various methods to compensate for this shortcoming, among which e-learning gained a special place.Materials &

    Methods

     We have created a virtual studio in Akbar children Hospital in Mashhad from March to May 2020, in which the respected professors of the Pediatrics Department of Mashhad University of Medical Sciences recorded the courses assigned to externs, interns and assistants in this studio. We launched the Healthstudio program, which provided us with a number of capabilities, including video editing, to improve the quality of our recorded videos.

    Results

    A studio was equipped as a virtual recording space in which 50 training sessions were provided in the form of links for externs, 27 training sessions for interns and 5 training sessions for assistants. The links were also prepared in NAVID system(Special university learning software).

    Conclusion

    We tried to provide a suitable infrastructure for medical students to have quick and easy access to educational content.

    Keywords: e-learning, Covid-19, extern, intern
  • Hassan Boskabadi, Majid Ghayour Mobarhan, Fatemeh Bagheri, Nafiseh Pourbadakhshan*
    Background

    Jaundice can be observed in two-thirds of infants. Bilirubin prevents damage to the DNA from the oxidative stress of reactive oxygen species (ROS). Moreover, bilirubin has anti-inflammatory and anti-apoptotic roles in addition to antioxidant properties.

    Objectives

    We decided to compare pro-oxidant-antioxidant balance (PAB) in physiologic and pathologic jaundice.

    Methods

    This cross-sectional study evaluated 171 infants more than 35 weeks of gestational and > 2 days of postnatal age who were admitted to the Ghaem Hospital with jaundice from 2017 to 2019. Infants with bilirubin levels less or equal to 14 mg/dL on the jaundice meter were put in the physiologic jaundice group and infants with bilirubin higher than 15 mg/dL on the jaundice meter were entered into the study as the pathologic jaundice group. A questionnaire containing data regarding neonate’s characteristics and the mother’s medical history was filled out for each infant. Bilirubin levels, hematocrit, direct and or indirect Combs, reticulocytes, and PAB were evaluated in the case group.

    Results

    The average age of the enrolled neonates was 7.3 ± 4.11 days and 52.4% of them were male. Between two groups of physiologic and pathologic jaundice, gestational age (P = 0.010), parity (P = 0.001) and PAB (P = 0.000) were significantly different. Overall, the amounts of the mentioned parameters in the pathologic jaundice group were less than the physiologic jaundice group.

    Conclusions

    A pathological increase in bilirubin levels irrespective of its neurotoxic properties can change the pro-oxidant-antioxidant balance in favor of antioxidants. It seems that neurotoxic mechanism of bilirubin in pathological amounts differ with its antioxidant effects.

    Keywords: Hyperbilirubinemia, Infants, Physiologic Jaundice, Pro-Oxidant-Antioxidant Balance (PAB), Pathologic Jaundice
  • Hamid Farhangi, Elham Bakhtiari, Nafiseh Pourbadakhshan *
    Background
    Children with cancer are in risk of malnutrition. Nutritional risk assessment is more importance in developing countries. The aim of present study was to investigate the nutritional risk in admitted children with cancer.
    Materials And Methods
    One hundred admitted children newly diagnosed with cancer were studied at the time of admission, after 3 and 6 months. Demographic characteristics and anthropometrics indexes were recorded via standard and calibrated tools. Nutritional risk assessed according to modified Screening Tool for Assessment of Malnutrition in Pediatrics (STAMP). Statistical analysis was performed using SPSS software (version 16.0).
    Results
    Of the 100 children 55 patients (55%) were female. The average age was 3.46±3.3 years. Hematologic tumors constituted 73.5% of patient. All patients were in nutritional risk. There was no patient with low nutritional risk during study; 17 patients (17%), 53 patients (56.4%), and 41 patients (43.6%) diagnosed with medium nutritional risk at the time of admission, after 3 and 6 months, respectively; 83 patients (83%), 41 patients (43.6%), and 40 patients (43%) diagnosed with high nutritional risk at the time of admission, after 3 and 6 months, respectively. Difference was significant (p
    Conclusion
    According to modified STAMP results, all studied patients were in the nutritional risk. Nutritional risk decreased during study. The nutritional risk decreased after 6 months in children newly diagnosed with cancer compared with the time of admission.
    Keywords: Cancer, Child, Neoplasm, Nutritional risk
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